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Protein

BAG family molecular chaperone regulator 2

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-BTA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 2
Short name:
BAG-2
Alternative name(s):
Bcl-2-associated athanogene 2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 211210BAG family molecular chaperone regulator 2PRO_0000282938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei20 – 201PhosphoserineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3ZBG5.
PRIDEiQ3ZBG5.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007039.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 18981BAGPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili20 – 6142Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 BAG domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3633. Eukaryota.
ENOG410XRW0. LUCA.
GeneTreeiENSGT00390000017590.
HOGENOMiHOG000073529.
HOVERGENiHBG004808.
InParanoidiQ3ZBG5.
KOiK09556.
OMAiKIQAKMN.
OrthoDBiEOG7HTHJ7.
TreeFamiTF102012.

Family and domain databases

InterProiIPR003103. BAG_domain.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZBG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQARISAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE
60 70 80 90 100
QEKEVLLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET
110 120 130 140 150
IRSPQQQESL KHATRIIDEV VSKFLDDLGN ARSHLMSLYS ACSSEVPAGP
160 170 180 190 200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENADKAIKL LEHSKGAASK
210
TLQQNAEARF N
Length:211
Mass (Da):23,649
Last modified:September 27, 2005 - v1
Checksum:i727D6613B6F48A10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103308 mRNA. Translation: AAI03309.1.
RefSeqiNP_001029436.1. NM_001034264.1.
UniGeneiBt.44554.

Genome annotation databases

EnsembliENSBTAT00000007039; ENSBTAP00000007039; ENSBTAG00000005355.
GeneIDi506107.
KEGGibta:506107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103308 mRNA. Translation: AAI03309.1.
RefSeqiNP_001029436.1. NM_001034264.1.
UniGeneiBt.44554.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007039.

Proteomic databases

PaxDbiQ3ZBG5.
PRIDEiQ3ZBG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007039; ENSBTAP00000007039; ENSBTAG00000005355.
GeneIDi506107.
KEGGibta:506107.

Organism-specific databases

CTDi9532.

Phylogenomic databases

eggNOGiKOG3633. Eukaryota.
ENOG410XRW0. LUCA.
GeneTreeiENSGT00390000017590.
HOGENOMiHOG000073529.
HOVERGENiHBG004808.
InParanoidiQ3ZBG5.
KOiK09556.
OMAiKIQAKMN.
OrthoDBiEOG7HTHJ7.
TreeFamiTF102012.

Enzyme and pathway databases

ReactomeiR-BTA-3371453. Regulation of HSF1-mediated heat shock response.

Family and domain databases

InterProiIPR003103. BAG_domain.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiBAG2_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: July 6, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.