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Protein

BAG family molecular chaperone regulator 2

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-BTA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 2
Short name:
BAG-2
Alternative name(s):
Bcl-2-associated athanogene 2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:26406 BAG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002829382 – 211BAG family molecular chaperone regulator 2Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3ZBG5
PRIDEiQ3ZBG5

Expressioni

Gene expression databases

BgeeiENSBTAG00000005355

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. May interact with NWD1. Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007039

Structurei

3D structure databases

SMRiQ3ZBG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 189BAGPROSITE-ProRule annotationAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 61Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3633 Eukaryota
ENOG410XRW0 LUCA
GeneTreeiENSGT00390000017590
HOGENOMiHOG000073529
HOVERGENiHBG004808
InParanoidiQ3ZBG5
KOiK09556
OMAiQLEMRVE
OrthoDBiEOG091G0G1G
TreeFamiTF102012

Family and domain databases

InterProiView protein in InterPro
IPR037689 BAG2
IPR003103 BAG_domain
PANTHERiPTHR12334 PTHR12334, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZBG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQARISAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE
60 70 80 90 100
QEKEVLLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET
110 120 130 140 150
IRSPQQQESL KHATRIIDEV VSKFLDDLGN ARSHLMSLYS ACSSEVPAGP
160 170 180 190 200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENADKAIKL LEHSKGAASK
210
TLQQNAEARF N
Length:211
Mass (Da):23,649
Last modified:September 27, 2005 - v1
Checksum:i727D6613B6F48A10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103308 mRNA Translation: AAI03309.1
RefSeqiNP_001029436.1, NM_001034264.1
UniGeneiBt.44554

Genome annotation databases

EnsembliENSBTAT00000007039; ENSBTAP00000007039; ENSBTAG00000005355
GeneIDi506107
KEGGibta:506107

Similar proteinsi

Entry informationi

Entry nameiBAG2_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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