Reviewed, UniProtKB/Swiss-Prot Q3ZBF9 (PLPP_BOVIN)

Names and origin

Protein names

Recommended name:
    Pyridoxal phosphate phosphatase
      Short name=PLP phosphatase
    EC=3.1.3.74

Gene names

Name:

PDXP

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and Pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP By similarity.
Catalytic activity	Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.
Cofactor	Divalent ions. Magnesium is the most effective By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily.

Ontologies

Keywords
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Pyridoxal phosphate phosphatase		PRO_0000254016
Sites
	Active site	25	1	Nucleophile By similarity
	Active site	27	1	Proton donor By similarity
	Metal binding	25	1	Magnesium By similarity
	Metal binding	27	1	Magnesium By similarity
	Metal binding	238	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZBF9-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: A3F0B3AA9D5D1E19	FASTA	296	31,749
	10 20 30 40 50 60 MARCERLRGA ALRDVVGRAQ GVLFDCNGVL WNGERAVPGA PELLERLAQA GKATLFVSNN 70 80 90 100 110 120 SRRARPELAL RFARLGFGGL RSEQLFSSAL CAARLLRQRL LGPPDTQGAV FVLGGEGLRA 130 140 150 160 170 180 ELRAAGLRLA GDPSEDPGAA PRVRAVLVGY DEHFSFAKLS EACAHLRDPD CLLVATDRDP 190 200 210 220 230 240 WHPLSDGSRT PGTGSLAAAV ETASGRQALV VGKPSPYMFE CITEHFSVDP GRTLMVGDRL 250 260 270 280 290 ETDILFGHRC GMTTVLTLTG VSSLEEAQAY LAAGQHDLVP HYYVESIADL MEGLED

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC103329 mRNA. Translation: AAI03330.1.
IPI	IPI00713190.
RefSeq	NP_001030207.1.
UniGene	Bt.45290
3D structure databases
SMR	Q3ZBF9. Positions 1-294.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000030255. Bos taurus. [Contig view]
GeneID	506308.
KEGG	bta:506308.
Phylogenomic databases
HOVERGEN	Q3ZBF9.
Enzyme and pathway databases
BRENDA	3.1.3.74. 251.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006357. HAD-SF_hydro_IIA. IPR006349. PGP_euk. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01460. HAD-SF-IIA. 1 hit. TIGR01452. PGP_euk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLPP_BOVIN

Accession

Primary (citable) accession number: Q3ZBF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	September 27, 2005
Last modified:	February 10, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)