Q3ZBF7 (TEBP_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prostaglandin E synthase 3
EC=5.3.99.3

Alternative name(s):
Cytosolic prostaglandin E2 synthase
Short name=cPGES

Gene names

Name:

PTGES3

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes By similarity.
Catalytic activity	(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
Pathway	Lipid metabolism; prostaglandin biosynthesis.
Subunit structure	Binds to the progesterone receptor By similarity. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex By similarity.
Subcellular location	Cytoplasm By similarity Ref.1.
Tissue specificity	Detected in testis and ovary, at lower levels in endometrium, myometrium, kidney and lung, and only faintly in spleen, heart and muscle (at protein level). Expressed at high levels in glandular and luminal epithelial cells of the endometrium, but also detected in stromal cells (at protein level). Ref.1
Induction	Expression declines progressively during the estrous cycle; it is higher at the beginning (days 1-9) and then follows a progressive decline to reach its lowest point at the follicular phase of the cycle (days 19-21). Ref.1
Sequence similarities	Belongs to the p23/wos2 family. Contains 1 CS domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Prostaglandin biosynthesis Prostaglandin metabolism
Cellular component	Cytoplasm
Molecular function	Isomerase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chaperone cofactor-dependent protein refolding Inferred from electronic annotation. Source: Compara prostaglandin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell telomerase holoenzyme complex Inferred from electronic annotation. Source: Compara
Molecular_function	prostaglandin-E synthase activity Inferred from electronic annotation. Source: EC telomerase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Prostaglandin E synthase 3		PRO_0000288778
Regions
	Domain	1 – 90	90	CS
	Compositional bias	108 – 160	53	Asp/Glu-rich
Amino acid modifications
	Modified residue	33	1	N6-acetyllysine By similarity
	Modified residue	113	1	Phosphoserine By similarity
	Modified residue	118	1	Phosphoserine By similarity
	Modified residue	148	1	Phosphoserine By similarity
	Modified residue	151	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	12 – 13	2	RD → GG in AAU04847. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q3ZBF7 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 23538BB9D7AFD73F	FASTA	160	18,697
	10 20 30 40 50 60 MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID 70 80 90 100 110 120 PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF 130 140 150 160 DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression and contribution of three different isoforms of prostaglandin E synthase in the bovine endometrium." Parent J., Fortier M.A. Biol. Reprod. 73:36-44(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY. Tissue: Endometrium.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY692440 mRNA. Translation: AAU04847.1. BC103350 mRNA. Translation: AAI03351.1.
IPI	IPI00712216.
RefSeq	NP_001007807.2. NM_001007806.2.
UniGene	Bt.49581.
3D structure databases
ProteinModelPortal	Q3ZBF7.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000023908.
Proteomic databases
PRIDE	Q3ZBF7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000023908; ENSBTAP00000023908; ENSBTAG00000017967.
GeneID	493638.
KEGG	bta:493638.
Organism-specific databases
CTD	10728.
Phylogenomic databases
eggNOG	NOG283591.
GeneTree	ENSGT00510000046493.
HOGENOM	HOG000177563.
HOVERGEN	HBG002143.
InParanoid	Q3ZBF7.
KO	K15730.
OMA	TICLEDC.
OrthoDB	EOG48WC3C.
Enzyme and pathway databases
UniPathway	UPA00662.
Family and domain databases
InterPro	IPR007052. CS-like_domain. IPR017447. CS_domain. IPR008978. HSP20-like_chaperone. [Graphical view]
Pfam	PF04969. CS. 1 hit. [Graphical view]
SUPFAM	SSF49764. HSP20_chap. 1 hit.
PROSITE	PS51203. CS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20865445.

Entry information

Entry name

TEBP_BOVIN

Accession

Primary (citable) accession number: Q3ZBF7
Secondary accession number(s): Q66LN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	September 27, 2005
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program