ID   ACADS_BOVIN             Reviewed;         412 AA.
AC   Q3ZBF6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 36.
DE   RecName: Full=Short-chain specific acyl-CoA dehydrogenase, mitochondrial;
DE            Short=SCAD;
DE            EC=1.3.99.2;
DE   AltName: Full=Butyryl-CoA dehydrogenase;
DE   Flags: Precursor;
GN   Name=ACADS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Butanoyl-CoA + acceptor = 2-butenoyl-CoA +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-
CC       oxidation.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- MISCELLANEOUS: A number of straight-chain acyl-CoA dehydrogenases
CC       of different substrate specificities are present in mammalian
CC       tissues.
CC   -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
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DR   EMBL; BC103365; AAI03366.1; -; mRNA.
DR   IPI; IPI00718020; -.
DR   RefSeq; NP_001029573.1; -.
DR   UniGene; Bt.49540; -.
DR   SMR; Q3ZBF6; 28-411.
DR   Ensembl; ENSBTAG00000007484; Bos taurus.
DR   GeneID; 511222; -.
DR   KEGG; bta:511222; -.
DR   HOVERGEN; Q3ZBF6; -.
DR   BRENDA; 1.3.99.2; 251.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0004085; F:butyryl-CoA dehydrogenase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006089; Acyl-CoA_DH_CS.
DR   InterPro; IPR006092; Acyl-CoA_DH_N.
DR   InterPro; IPR006090; Acyl-CoA_Oxase/DH_1.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_M.
DR   InterPro; IPR013786; AcylCoA_DH/ox_N.
DR   InterPro; IPR013764; AcylCoA_oxidase/DH_1/2_C.
DR   Gene3D; G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
DR   Gene3D; G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
DR   Gene3D; G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR   PROSITE; PS00072; ACYL_COA_DH_1; 1.
DR   PROSITE; PS00073; ACYL_COA_DH_2; 1.
PE   2: Evidence at transcript level;
KW   FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism;
KW   Mitochondrion; Oxidoreductase; Transit peptide.
FT   TRANSIT       1     24       Mitochondrion (By similarity).
FT   CHAIN        25    412       Short-chain specific acyl-CoA
FT                                dehydrogenase, mitochondrial.
FT                                /FTId=PRO_0000281994.
FT   NP_BIND     152    161       FAD (By similarity).
FT   NP_BIND     185    187       FAD (By similarity).
FT   NP_BIND     365    369       FAD (By similarity).
FT   NP_BIND     394    396       FAD (By similarity).
FT   ACT_SITE    392    392       Proton acceptor (By similarity).
FT   BINDING     297    297       FAD (By similarity).
SQ   SEQUENCE   412 AA;  44552 MW;  3845B25B0DEF5265 CRC64;
     MAATLLARAC GLVRGAPWPW GWRRLHTVYQ SVELPETHQM LRQTCRDFAE KELFPIAAQV
     DKEHRFPAAQ VKKMGELGLM AMNVPEELSG AGLDYLAYSI AMEEISRGCA STGVIMSVNN
     SLYLGPILKF GTKEQKQQWV APFTSGDKIG CFALSEPGNG SDAGAAATTA RADGDSWVLS
     GTKAWITNAW EASAVVVFAS TDRSLHNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN
     LIFEDRRIPK DSLLGEPGLG FKIAMQTLDT GRIGIASQAL GIAQAALDCA VTYAENRSAF
     GAPLTKLQAI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKEAAMAKL AASEAATAIT
     HQAMQILGGM GYVKEMPAER HYRDARITEI YEGTSEIQRL VVAGHLLKSY RS
//