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Q3ZBF6 (ACADS_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Short name=SCAD
EC=1.3.8.1
Alternative name(s):
Butyryl-CoA dehydrogenase
Gene names
Name:ACADS
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; mitochondrial fatty acid beta-oxidation.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion By similarity
Chain25 – 412388Short-chain specific acyl-CoA dehydrogenase, mitochondrial
PRO_0000281994

Regions

Nucleotide binding152 – 16110FAD By similarity
Nucleotide binding185 – 1873FAD By similarity
Nucleotide binding365 – 3695FAD By similarity
Nucleotide binding365 – 3695FAD; shared with dimeric partner By similarity
Nucleotide binding394 – 3963FAD By similarity
Region269 – 2724Substrate binding By similarity

Sites

Active site3921Proton acceptor By similarity
Binding site1611Substrate; via carbonyl oxygen By similarity
Binding site2971FAD By similarity
Binding site2971FAD; shared with dimeric partner By similarity
Binding site3081FAD By similarity
Binding site3931Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ZBF6 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 3845B25B0DEF5265

FASTA41244,552
        10         20         30         40         50         60 
MAATLLARAC GLVRGAPWPW GWRRLHTVYQ SVELPETHQM LRQTCRDFAE KELFPIAAQV 

        70         80         90        100        110        120 
DKEHRFPAAQ VKKMGELGLM AMNVPEELSG AGLDYLAYSI AMEEISRGCA STGVIMSVNN 

       130        140        150        160        170        180 
SLYLGPILKF GTKEQKQQWV APFTSGDKIG CFALSEPGNG SDAGAAATTA RADGDSWVLS 

       190        200        210        220        230        240 
GTKAWITNAW EASAVVVFAS TDRSLHNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN 

       250        260        270        280        290        300 
LIFEDRRIPK DSLLGEPGLG FKIAMQTLDT GRIGIASQAL GIAQAALDCA VTYAENRSAF 

       310        320        330        340        350        360 
GAPLTKLQAI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKEAAMAKL AASEAATAIT 

       370        380        390        400        410 
HQAMQILGGM GYVKEMPAER HYRDARITEI YEGTSEIQRL VVAGHLLKSY RS 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC103365 mRNA. Translation: AAI03366.1.
IPIIPI00718020.
RefSeqNP_001029573.1. NM_001034401.2.
UniGeneBt.49540.

3D structure databases

ProteinModelPortalQ3ZBF6.
SMRQ3ZBF6. Positions 34-412.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000009844.

Proteomic databases

PaxDbQ3ZBF6.
PRIDEQ3ZBF6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID511222.
KEGGbta:511222.

Organism-specific databases

CTD35.

Phylogenomic databases

eggNOGCOG1960.
HOGENOMHOG000131659.
HOVERGENHBG000224.
InParanoidQ3ZBF6.
KOK00248.
OrthoDBEOG4ZPDVH.

Enzyme and pathway databases

BioCycCATTLE:511222-MONOMER.
SABIO-RKQ3ZBF6.
UniPathwayUPA00660.

Family and domain databases

Gene3D1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProIPR006089. Acyl-CoA_DH_CS.
IPR006092. Acyl-CoA_DH_N.
IPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase.
[Graphical view]
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMSSF56645. AcylCoA_dehyd_NM. 1 hit.
SSF47203. AcylCoADH_C_like. 1 hit.
PROSITEPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20869829.

Entry information

Entry nameACADS_BOVIN
AccessionPrimary (citable) accession number: Q3ZBF6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: May 29, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families