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Reviewed, UniProtKB/Swiss-Prot Q3ZBF6 (ACADS_BOVIN)

Last modified February 9, 2010. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Short-chain specific acyl-CoA dehydrogenase, mitochondrial
      Short name=SCAD
    EC=1.3.99.2
Alternative name(s):
    Butyryl-CoA dehydrogenase
Gene names
Name: ACADS
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

Butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; mitochondrial fatty acid beta-oxidation.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

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Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processfatty acid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionFAD binding

Inferred from electronic annotation. Source: InterPro

butyryl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion By similarity
Chain25 – 412388Short-chain specific acyl-CoA dehydrogenase, mitochondrial
PRO_0000281994

Regions

Nucleotide binding152 – 16110FAD By similarity
Nucleotide binding185 – 1873FAD By similarity
Nucleotide binding365 – 3695FAD By similarity
Nucleotide binding365 – 3695FAD; shared with dimeric partner By similarity
Nucleotide binding394 – 3963FAD By similarity
Region269 – 2724Substrate binding By similarity

Sites

Active site3921Proton acceptor By similarity
Binding site1611Substrate; via carbonyl oxygen By similarity
Binding site2971FAD By similarity
Binding site2971FAD; shared with dimeric partner By similarity
Binding site3081FAD By similarity
Binding site3931Substrate; via amide nitrogen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3ZBF6-1 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 3845B25B0DEF5265

FASTA41244,552
        10         20         30         40         50         60 
MAATLLARAC GLVRGAPWPW GWRRLHTVYQ SVELPETHQM LRQTCRDFAE KELFPIAAQV 

        70         80         90        100        110        120 
DKEHRFPAAQ VKKMGELGLM AMNVPEELSG AGLDYLAYSI AMEEISRGCA STGVIMSVNN 

       130        140        150        160        170        180 
SLYLGPILKF GTKEQKQQWV APFTSGDKIG CFALSEPGNG SDAGAAATTA RADGDSWVLS 

       190        200        210        220        230        240 
GTKAWITNAW EASAVVVFAS TDRSLHNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN 

       250        260        270        280        290        300 
LIFEDRRIPK DSLLGEPGLG FKIAMQTLDT GRIGIASQAL GIAQAALDCA VTYAENRSAF 

       310        320        330        340        350        360 
GAPLTKLQAI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKEAAMAKL AASEAATAIT 

       370        380        390        400        410 
HQAMQILGGM GYVKEMPAER HYRDARITEI YEGTSEIQRL VVAGHLLKSY RS

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC103365 mRNA. Translation: AAI03366.1.
IPIIPI00718020.
RefSeqNP_001029573.1.
UniGeneBt.49540

3D structure databases

HSSPHSSP built from PDB template 1WS9 based on UniProtKB Q5SGZ2.
SMRQ3ZBF6. Positions 34-412.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3ZBF6.

Genome annotation databases

EnsemblENSBTAT00000009844; ENSBTAP00000009844; ENSBTAG00000007484; Bos taurus. [Genome view]
GeneID511222.
KEGGbta:511222.

Organism-specific databases

CTD511222.

Phylogenomic databases

eggNOGmaNOG07842.
HOVERGENQ3ZBF6.
InParanoidQ3ZBF6.

Enzyme and pathway databases

BRENDA1.3.99.2. 251.

Family and domain databases

InterProIPR006089. Acyl-CoA_DH_CS.
IPR006092. Acyl-CoA_DH_N.
IPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase.
IPR013764. AcylCoA_oxidase/DH_1/2_C.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
PROSITEPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameACADS_BOVIN
AccessionPrimary (citable) accession number: Q3ZBF6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents