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Q3ZBF6

- ACADS_BOVIN

UniProt

Q3ZBF6 - ACADS_BOVIN

Protein

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene

ACADS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei161 – 1611Substrate; via carbonyl oxygenBy similarity
    Binding sitei297 – 2971FADBy similarity
    Binding sitei297 – 2971FAD; shared with dimeric partnerBy similarity
    Binding sitei308 – 3081FADBy similarity
    Active sitei392 – 3921Proton acceptorBy similarity
    Binding sitei393 – 3931Substrate; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi152 – 16110FADBy similarity
    Nucleotide bindingi185 – 1873FADBy similarity
    Nucleotide bindingi365 – 3695FADBy similarity
    Nucleotide bindingi365 – 3695FAD; shared with dimeric partnerBy similarity
    Nucleotide bindingi394 – 3963FADBy similarity

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    SABIO-RKQ3ZBF6.
    UniPathwayiUPA00660.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.1)
    Short name:
    SCAD
    Alternative name(s):
    Butyryl-CoA dehydrogenase
    Gene namesi
    Name:ACADS
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionBy similarityAdd
    BLAST
    Chaini25 – 412388Short-chain specific acyl-CoA dehydrogenase, mitochondrialPRO_0000281994Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511N6-acetyllysine; alternateBy similarity
    Modified residuei51 – 511N6-succinyllysine; alternateBy similarity
    Modified residuei72 – 721N6-acetyllysineBy similarity
    Modified residuei129 – 1291N6-acetyllysine; alternateBy similarity
    Modified residuei129 – 1291N6-succinyllysine; alternateBy similarity
    Modified residuei208 – 2081N6-acetyllysineBy similarity
    Modified residuei262 – 2621N6-acetyllysine; alternateBy similarity
    Modified residuei262 – 2621N6-succinyllysine; alternateBy similarity
    Modified residuei306 – 3061N6-acetyllysine; alternateBy similarity
    Modified residuei306 – 3061N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ3ZBF6.
    PRIDEiQ3ZBF6.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000009844.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZBF6.
    SMRiQ3ZBF6. Positions 34-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni269 – 2724Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the acyl-CoA dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1960.
    HOGENOMiHOG000131659.
    HOVERGENiHBG000224.
    InParanoidiQ3ZBF6.
    KOiK00248.

    Family and domain databases

    Gene3Di1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProiIPR006089. Acyl-CoA_DH_CS.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
    PS00073. ACYL_COA_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3ZBF6-1 [UniParc]FASTAAdd to Basket

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    MAATLLARAC GLVRGAPWPW GWRRLHTVYQ SVELPETHQM LRQTCRDFAE    50
    KELFPIAAQV DKEHRFPAAQ VKKMGELGLM AMNVPEELSG AGLDYLAYSI 100
    AMEEISRGCA STGVIMSVNN SLYLGPILKF GTKEQKQQWV APFTSGDKIG 150
    CFALSEPGNG SDAGAAATTA RADGDSWVLS GTKAWITNAW EASAVVVFAS 200
    TDRSLHNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN LIFEDRRIPK 250
    DSLLGEPGLG FKIAMQTLDT GRIGIASQAL GIAQAALDCA VTYAENRSAF 300
    GAPLTKLQAI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKEAAMAKL 350
    AASEAATAIT HQAMQILGGM GYVKEMPAER HYRDARITEI YEGTSEIQRL 400
    VVAGHLLKSY RS 412
    Length:412
    Mass (Da):44,552
    Last modified:September 27, 2005 - v1
    Checksum:i3845B25B0DEF5265
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103365 mRNA. Translation: AAI03366.1.
    RefSeqiNP_001029573.1. NM_001034401.2.
    UniGeneiBt.49540.

    Genome annotation databases

    GeneIDi511222.
    KEGGibta:511222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103365 mRNA. Translation: AAI03366.1 .
    RefSeqi NP_001029573.1. NM_001034401.2.
    UniGenei Bt.49540.

    3D structure databases

    ProteinModelPortali Q3ZBF6.
    SMRi Q3ZBF6. Positions 34-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000009844.

    Proteomic databases

    PaxDbi Q3ZBF6.
    PRIDEi Q3ZBF6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 511222.
    KEGGi bta:511222.

    Organism-specific databases

    CTDi 35.

    Phylogenomic databases

    eggNOGi COG1960.
    HOGENOMi HOG000131659.
    HOVERGENi HBG000224.
    InParanoidi Q3ZBF6.
    KOi K00248.

    Enzyme and pathway databases

    UniPathwayi UPA00660 .
    SABIO-RK Q3ZBF6.

    Miscellaneous databases

    NextBioi 20869829.

    Family and domain databases

    Gene3Di 1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProi IPR006089. Acyl-CoA_DH_CS.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
    PS00073. ACYL_COA_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiACADS_BOVIN
    AccessioniPrimary (citable) accession number: Q3ZBF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3