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Q3ZBF6

- ACADS_BOVIN

UniProt

Q3ZBF6 - ACADS_BOVIN

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Protein

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene

ACADS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei161 – 1611Substrate; via carbonyl oxygenBy similarity
Binding sitei297 – 2971FADBy similarity
Binding sitei297 – 2971FAD; shared with dimeric partnerBy similarity
Binding sitei308 – 3081FADBy similarity
Active sitei392 – 3921Proton acceptorBy similarity
Binding sitei393 – 3931Substrate; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi152 – 16110FADBy similarity
Nucleotide bindingi185 – 1873FADBy similarity
Nucleotide bindingi365 – 3695FADBy similarity
Nucleotide bindingi365 – 3695FAD; shared with dimeric partnerBy similarity
Nucleotide bindingi394 – 3963FADBy similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

SABIO-RKQ3ZBF6.
UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.1)
Short name:
SCAD
Alternative name(s):
Butyryl-CoA dehydrogenase
Gene namesi
Name:ACADS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionBy similarityAdd
BLAST
Chaini25 – 412388Short-chain specific acyl-CoA dehydrogenase, mitochondrialPRO_0000281994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-acetyllysine; alternateBy similarity
Modified residuei51 – 511N6-succinyllysine; alternateBy similarity
Modified residuei72 – 721N6-acetyllysineBy similarity
Modified residuei129 – 1291N6-acetyllysine; alternateBy similarity
Modified residuei129 – 1291N6-succinyllysine; alternateBy similarity
Modified residuei208 – 2081N6-acetyllysineBy similarity
Modified residuei262 – 2621N6-acetyllysine; alternateBy similarity
Modified residuei262 – 2621N6-succinyllysine; alternateBy similarity
Modified residuei306 – 3061N6-acetyllysine; alternateBy similarity
Modified residuei306 – 3061N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3ZBF6.
PRIDEiQ3ZBF6.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009844.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBF6.
SMRiQ3ZBF6. Positions 34-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2724Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
HOVERGENiHBG000224.
InParanoidiQ3ZBF6.
KOiK00248.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZBF6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATLLARAC GLVRGAPWPW GWRRLHTVYQ SVELPETHQM LRQTCRDFAE
60 70 80 90 100
KELFPIAAQV DKEHRFPAAQ VKKMGELGLM AMNVPEELSG AGLDYLAYSI
110 120 130 140 150
AMEEISRGCA STGVIMSVNN SLYLGPILKF GTKEQKQQWV APFTSGDKIG
160 170 180 190 200
CFALSEPGNG SDAGAAATTA RADGDSWVLS GTKAWITNAW EASAVVVFAS
210 220 230 240 250
TDRSLHNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN LIFEDRRIPK
260 270 280 290 300
DSLLGEPGLG FKIAMQTLDT GRIGIASQAL GIAQAALDCA VTYAENRSAF
310 320 330 340 350
GAPLTKLQAI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKEAAMAKL
360 370 380 390 400
AASEAATAIT HQAMQILGGM GYVKEMPAER HYRDARITEI YEGTSEIQRL
410
VVAGHLLKSY RS
Length:412
Mass (Da):44,552
Last modified:September 27, 2005 - v1
Checksum:i3845B25B0DEF5265
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103365 mRNA. Translation: AAI03366.1.
RefSeqiNP_001029573.1. NM_001034401.2.
UniGeneiBt.49540.

Genome annotation databases

GeneIDi511222.
KEGGibta:511222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103365 mRNA. Translation: AAI03366.1 .
RefSeqi NP_001029573.1. NM_001034401.2.
UniGenei Bt.49540.

3D structure databases

ProteinModelPortali Q3ZBF6.
SMRi Q3ZBF6. Positions 34-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009844.

Proteomic databases

PaxDbi Q3ZBF6.
PRIDEi Q3ZBF6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 511222.
KEGGi bta:511222.

Organism-specific databases

CTDi 35.

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
HOVERGENi HBG000224.
InParanoidi Q3ZBF6.
KOi K00248.

Enzyme and pathway databases

UniPathwayi UPA00660 .
SABIO-RK Q3ZBF6.

Miscellaneous databases

NextBioi 20869829.

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiACADS_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3