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Q3ZBF6

- ACADS_BOVIN

UniProt

Q3ZBF6 - ACADS_BOVIN

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Protein
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene
ACADS
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei161 – 1611Substrate; via carbonyl oxygen By similarity
Binding sitei297 – 2971FAD By similarity
Binding sitei297 – 2971FAD; shared with dimeric partner By similarity
Binding sitei308 – 3081FAD By similarity
Active sitei392 – 3921Proton acceptor By similarity
Binding sitei393 – 3931Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi152 – 16110FAD By similarity
Nucleotide bindingi185 – 1873FAD By similarity
Nucleotide bindingi365 – 3695FAD By similarity
Nucleotide bindingi365 – 3695FAD; shared with dimeric partner By similarity
Nucleotide bindingi394 – 3963FAD By similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

SABIO-RKQ3ZBF6.
UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.1)
Short name:
SCAD
Alternative name(s):
Butyryl-CoA dehydrogenase
Gene namesi
Name:ACADS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion By similarity
Add
BLAST
Chaini25 – 412388Short-chain specific acyl-CoA dehydrogenase, mitochondrial
PRO_0000281994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-acetyllysine; alternate By similarity
Modified residuei51 – 511N6-succinyllysine; alternate By similarity
Modified residuei72 – 721N6-acetyllysine By similarity
Modified residuei129 – 1291N6-acetyllysine; alternate By similarity
Modified residuei129 – 1291N6-succinyllysine; alternate By similarity
Modified residuei208 – 2081N6-acetyllysine By similarity
Modified residuei262 – 2621N6-acetyllysine; alternate By similarity
Modified residuei262 – 2621N6-succinyllysine; alternate By similarity
Modified residuei306 – 3061N6-acetyllysine; alternate By similarity
Modified residuei306 – 3061N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3ZBF6.
PRIDEiQ3ZBF6.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009844.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBF6.
SMRiQ3ZBF6. Positions 34-412.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2724Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
HOVERGENiHBG000224.
InParanoidiQ3ZBF6.
KOiK00248.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZBF6-1 [UniParc]FASTAAdd to Basket

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MAATLLARAC GLVRGAPWPW GWRRLHTVYQ SVELPETHQM LRQTCRDFAE    50
KELFPIAAQV DKEHRFPAAQ VKKMGELGLM AMNVPEELSG AGLDYLAYSI 100
AMEEISRGCA STGVIMSVNN SLYLGPILKF GTKEQKQQWV APFTSGDKIG 150
CFALSEPGNG SDAGAAATTA RADGDSWVLS GTKAWITNAW EASAVVVFAS 200
TDRSLHNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN LIFEDRRIPK 250
DSLLGEPGLG FKIAMQTLDT GRIGIASQAL GIAQAALDCA VTYAENRSAF 300
GAPLTKLQAI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKEAAMAKL 350
AASEAATAIT HQAMQILGGM GYVKEMPAER HYRDARITEI YEGTSEIQRL 400
VVAGHLLKSY RS 412
Length:412
Mass (Da):44,552
Last modified:September 27, 2005 - v1
Checksum:i3845B25B0DEF5265
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103365 mRNA. Translation: AAI03366.1.
RefSeqiNP_001029573.1. NM_001034401.2.
UniGeneiBt.49540.

Genome annotation databases

GeneIDi511222.
KEGGibta:511222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103365 mRNA. Translation: AAI03366.1 .
RefSeqi NP_001029573.1. NM_001034401.2.
UniGenei Bt.49540.

3D structure databases

ProteinModelPortali Q3ZBF6.
SMRi Q3ZBF6. Positions 34-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009844.

Proteomic databases

PaxDbi Q3ZBF6.
PRIDEi Q3ZBF6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 511222.
KEGGi bta:511222.

Organism-specific databases

CTDi 35.

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
HOVERGENi HBG000224.
InParanoidi Q3ZBF6.
KOi K00248.

Enzyme and pathway databases

UniPathwayi UPA00660 .
SABIO-RK Q3ZBF6.

Miscellaneous databases

NextBioi 20869829.

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiACADS_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: March 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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