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Q3ZBD7

- G6PI_BOVIN

UniProt

Q3ZBD7 - G6PI_BOVIN

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Protein

Glucose-6-phosphate isomerase

Gene

GPI

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei358 – 3581Proton donorBy similarity
Active sitei389 – 3891By similarity
Active sitei519 – 5191By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. gluconeogenesis Source: UniProtKB-KW
  3. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Isomerase

Keywords - Biological processi

Angiogenesis, Gluconeogenesis, Glycolysis

Enzyme and pathway databases

ReactomeiREACT_224187. Glycolysis.
REACT_227222. Gluconeogenesis.
SABIO-RKQ3ZBD7.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Autocrine motility factor
Short name:
AMF
Neuroleukin
Short name:
NLK
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:GPI
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Cytoplasm. Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: Ensembl
  4. nucleus Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 557556Glucose-6-phosphate isomerasePRO_0000247641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei12 – 121N6-acetyllysineBy similarity
Modified residuei142 – 1421N6-acetyllysineBy similarity
Modified residuei185 – 1851Phosphoserine; by CK2By similarity

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3ZBD7.
PRIDEiQ3ZBD7.

Interactioni

Subunit structurei

Homodimer in the catalytically active form, monomer in the secreted form.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
GeneTreeiENSGT00390000000707.
HOGENOMiHOG000261370.
HOVERGENiHBG002877.
InParanoidiQ3ZBD7.
KOiK01810.
OMAiCGNELDN.
OrthoDBiEOG7FXZXV.
TreeFamiTF300436.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZBD7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALTQNPQF KKLKTWYEQH GSDLNLRRLF EGDRDRFNRF SLNLNTNHGH
60 70 80 90 100
ILVDYSKNLV TETVMQMLVD VAKSRGVEAA RERMFTGEKI NFTEDRAVLH
110 120 130 140 150
VALRNRSNAP ILVDGKDVMP EVNRVLEKMK SFCQRVRSGE WKGYSGKAIT
160 170 180 190 200
DVINIGIGGS DLGPLMVTEA LKPYSSEGPR VWFVSNIDGT HIAKTLATLN
210 220 230 240 250
PESSLFIIAS KTFTTQETIT NAETAKEWFL LSAKDPSAVA KHFVALSTNT
260 270 280 290 300
AKVKEFGIDP QNMFEFWDWV GGRYSLWSAI GLSIALHVGF DNFEQLLSGA
310 320 330 340 350
HWMDQHFRTT PLEKNAPVLL ALLGIWYINC FGCETHAMLP YDQYLHRFAA
360 370 380 390 400
YFQQGDMESN GKYITKSGTR VNYQTGPIVW GEPGTNGQHA FYQLIHQGTK
410 420 430 440 450
MIPCDFLIPV QSQHPIRNGL HHKILLANFL AQTEALMRGK STEEARKELQ
460 470 480 490 500
AAGRSPEDFE KLLPHKVFEG NRPTNSIVFT KLTPFILGAL IAMYEHKIFV
510 520 530 540 550
QGIIWDINSF DQWGVELGKQ LAKKIEPELD GSSPVTSHDS STNGLINFIK

QEREARS
Length:557
Mass (Da):62,855
Last modified:February 22, 2012 - v4
Checksum:iD932716D85FB2185
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701A → S in AAI03417. (PubMed:19393038)Curated
Sequence conflicti312 – 3121L → WRRTP in AAB97860. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02046903 Genomic DNA. No translation available.
BC103416 mRNA. Translation: AAI03417.1.
AF043228 mRNA. Translation: AAB97860.1.
RefSeqiNP_001035561.1. NM_001040471.1.
UniGeneiBt.49587.

Genome annotation databases

EnsembliENSBTAT00000008386; ENSBTAP00000008386; ENSBTAG00000006396.
GeneIDi280808.
KEGGibta:280808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02046903 Genomic DNA. No translation available.
BC103416 mRNA. Translation: AAI03417.1 .
AF043228 mRNA. Translation: AAB97860.1 .
RefSeqi NP_001035561.1. NM_001040471.1.
UniGenei Bt.49587.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q3ZBD7.
PRIDEi Q3ZBD7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000008386 ; ENSBTAP00000008386 ; ENSBTAG00000006396 .
GeneIDi 280808.
KEGGi bta:280808.

Organism-specific databases

CTDi 2821.

Phylogenomic databases

eggNOGi COG0166.
GeneTreei ENSGT00390000000707.
HOGENOMi HOG000261370.
HOVERGENi HBG002877.
InParanoidi Q3ZBD7.
KOi K01810.
OMAi CGNELDN.
OrthoDBi EOG7FXZXV.
TreeFami TF300436.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
Reactomei REACT_224187. Glycolysis.
REACT_227222. Gluconeogenesis.
SABIO-RK Q3ZBD7.

Miscellaneous databases

NextBioi 20804962.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. Savadye D.T.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-316.

Entry informationi

Entry nameiG6PI_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBD7
Secondary accession number(s): F1MD19, O46595
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 22, 2012
Last modified: October 29, 2014
This is version 71 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3