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Q3ZBD7

- G6PI_BOVIN

UniProt

Q3ZBD7 - G6PI_BOVIN

Protein

Glucose-6-phosphate isomerase

Gene

GPI

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 4 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei358 – 3581Proton donorBy similarity
    Active sitei389 – 3891By similarity
    Active sitei519 – 5191By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. gluconeogenesis Source: UniProtKB-KW
    3. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Cytokine, Isomerase

    Keywords - Biological processi

    Angiogenesis, Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    ReactomeiREACT_224187. Glycolysis.
    REACT_227222. Gluconeogenesis.
    SABIO-RKQ3ZBD7.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Autocrine motility factor
    Short name:
    AMF
    Neuroleukin
    Short name:
    NLK
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:GPI
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    Cytoplasm. Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: UniProtKB-KW
    3. nucleus Source: Ensembl
    4. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 557556Glucose-6-phosphate isomerasePRO_0000247641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei12 – 121N6-acetyllysineBy similarity
    Modified residuei142 – 1421N6-acetyllysineBy similarity
    Modified residuei185 – 1851Phosphoserine; by CK2By similarity

    Post-translational modificationi

    ISGylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ3ZBD7.
    PRIDEiQ3ZBD7.

    Interactioni

    Subunit structurei

    Homodimer in the catalytically active form, monomer in the secreted form.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    GeneTreeiENSGT00390000000707.
    HOGENOMiHOG000261370.
    HOVERGENiHBG002877.
    InParanoidiQ3ZBD7.
    KOiK01810.
    OMAiCGNELDN.
    OrthoDBiEOG7FXZXV.
    TreeFamiTF300436.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3ZBD7-1 [UniParc]FASTAAdd to Basket

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    MAALTQNPQF KKLKTWYEQH GSDLNLRRLF EGDRDRFNRF SLNLNTNHGH    50
    ILVDYSKNLV TETVMQMLVD VAKSRGVEAA RERMFTGEKI NFTEDRAVLH 100
    VALRNRSNAP ILVDGKDVMP EVNRVLEKMK SFCQRVRSGE WKGYSGKAIT 150
    DVINIGIGGS DLGPLMVTEA LKPYSSEGPR VWFVSNIDGT HIAKTLATLN 200
    PESSLFIIAS KTFTTQETIT NAETAKEWFL LSAKDPSAVA KHFVALSTNT 250
    AKVKEFGIDP QNMFEFWDWV GGRYSLWSAI GLSIALHVGF DNFEQLLSGA 300
    HWMDQHFRTT PLEKNAPVLL ALLGIWYINC FGCETHAMLP YDQYLHRFAA 350
    YFQQGDMESN GKYITKSGTR VNYQTGPIVW GEPGTNGQHA FYQLIHQGTK 400
    MIPCDFLIPV QSQHPIRNGL HHKILLANFL AQTEALMRGK STEEARKELQ 450
    AAGRSPEDFE KLLPHKVFEG NRPTNSIVFT KLTPFILGAL IAMYEHKIFV 500
    QGIIWDINSF DQWGVELGKQ LAKKIEPELD GSSPVTSHDS STNGLINFIK 550
    QEREARS 557
    Length:557
    Mass (Da):62,855
    Last modified:February 22, 2012 - v4
    Checksum:iD932716D85FB2185
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti170 – 1701A → S in AAI03417. (PubMed:19393038)Curated
    Sequence conflicti312 – 3121L → WRRTP in AAB97860. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02046903 Genomic DNA. No translation available.
    BC103416 mRNA. Translation: AAI03417.1.
    AF043228 mRNA. Translation: AAB97860.1.
    RefSeqiNP_001035561.1. NM_001040471.1.
    UniGeneiBt.49587.

    Genome annotation databases

    EnsembliENSBTAT00000008386; ENSBTAP00000008386; ENSBTAG00000006396.
    GeneIDi280808.
    KEGGibta:280808.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02046903 Genomic DNA. No translation available.
    BC103416 mRNA. Translation: AAI03417.1 .
    AF043228 mRNA. Translation: AAB97860.1 .
    RefSeqi NP_001035561.1. NM_001040471.1.
    UniGenei Bt.49587.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q3ZBD7.
    PRIDEi Q3ZBD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000008386 ; ENSBTAP00000008386 ; ENSBTAG00000006396 .
    GeneIDi 280808.
    KEGGi bta:280808.

    Organism-specific databases

    CTDi 2821.

    Phylogenomic databases

    eggNOGi COG0166.
    GeneTreei ENSGT00390000000707.
    HOGENOMi HOG000261370.
    HOVERGENi HBG002877.
    InParanoidi Q3ZBD7.
    KOi K01810.
    OMAi CGNELDN.
    OrthoDBi EOG7FXZXV.
    TreeFami TF300436.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    Reactomei REACT_224187. Glycolysis.
    REACT_227222. Gluconeogenesis.
    SABIO-RK Q3ZBD7.

    Miscellaneous databases

    NextBioi 20804962.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    3. Savadye D.T.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-316.

    Entry informationi

    Entry nameiG6PI_BOVIN
    AccessioniPrimary (citable) accession number: Q3ZBD7
    Secondary accession number(s): F1MD19, O46595
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 70 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3