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Q3ZBD7 (G6PI_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Autocrine motility factor
Short name=AMF
Neuroleukin
Short name=NLK
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:GPI
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons By similarity. HAMAP-Rule MF_00473

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subunit structure

Homodimer in the catalytically active form, monomer in the secreted form By similarity.

Subcellular location

Cytoplasm. Secreted By similarity HAMAP-Rule MF_00473.

Post-translational modification

ISGylated By similarity. HAMAP-Rule MF_00473

Sequence similarities

Belongs to the GPI family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 557556Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000247641

Sites

Active site3581Proton donor By similarity
Active site3891 By similarity
Active site5191 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue121N6-acetyllysine By similarity
Modified residue1421N6-acetyllysine By similarity
Modified residue1851Phosphoserine; by CK2 By similarity

Experimental info

Sequence conflict1701A → S in AAI03417. Ref.1
Sequence conflict3121L → WRRTP in AAB97860. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q3ZBD7 [UniParc].

Last modified February 22, 2012. Version 4.
Checksum: D932716D85FB2185

FASTA55762,855
        10         20         30         40         50         60 
MAALTQNPQF KKLKTWYEQH GSDLNLRRLF EGDRDRFNRF SLNLNTNHGH ILVDYSKNLV 

        70         80         90        100        110        120 
TETVMQMLVD VAKSRGVEAA RERMFTGEKI NFTEDRAVLH VALRNRSNAP ILVDGKDVMP 

       130        140        150        160        170        180 
EVNRVLEKMK SFCQRVRSGE WKGYSGKAIT DVINIGIGGS DLGPLMVTEA LKPYSSEGPR 

       190        200        210        220        230        240 
VWFVSNIDGT HIAKTLATLN PESSLFIIAS KTFTTQETIT NAETAKEWFL LSAKDPSAVA 

       250        260        270        280        290        300 
KHFVALSTNT AKVKEFGIDP QNMFEFWDWV GGRYSLWSAI GLSIALHVGF DNFEQLLSGA 

       310        320        330        340        350        360 
HWMDQHFRTT PLEKNAPVLL ALLGIWYINC FGCETHAMLP YDQYLHRFAA YFQQGDMESN 

       370        380        390        400        410        420 
GKYITKSGTR VNYQTGPIVW GEPGTNGQHA FYQLIHQGTK MIPCDFLIPV QSQHPIRNGL 

       430        440        450        460        470        480 
HHKILLANFL AQTEALMRGK STEEARKELQ AAGRSPEDFE KLLPHKVFEG NRPTNSIVFT 

       490        500        510        520        530        540 
KLTPFILGAL IAMYEHKIFV QGIIWDINSF DQWGVELGKQ LAKKIEPELD GSSPVTSHDS 

       550 
STNGLINFIK QEREARS 

« Hide

References

« Hide 'large scale' references
[1]"A whole-genome assembly of the domestic cow, Bos taurus."
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.
Genome Biol. 10:R42.01-R42.10(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[3]Savadye D.T.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-316.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DAAA02046903 Genomic DNA. No translation available.
BC103416 mRNA. Translation: AAI03417.1.
AF043228 mRNA. Translation: AAB97860.1.
RefSeqNP_001035561.1. NM_001040471.1.
UniGeneBt.49587.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ3ZBD7.
PRIDEQ3ZBD7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000008386; ENSBTAP00000008386; ENSBTAG00000006396.
GeneID280808.
KEGGbta:280808.

Organism-specific databases

CTD2821.

Phylogenomic databases

eggNOGCOG0166.
GeneTreeENSGT00390000000707.
HOGENOMHOG000261370.
HOVERGENHBG002877.
InParanoidQ3ZBD7.
KOK01810.
OMACGNELDN.
OrthoDBEOG7FXZXV.
TreeFamTF300436.

Enzyme and pathway databases

SABIO-RKQ3ZBD7.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804962.

Entry information

Entry nameG6PI_BOVIN
AccessionPrimary (citable) accession number: Q3ZBD7
Secondary accession number(s): F1MD19, O46595
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 22, 2012
Last modified: June 11, 2014
This is version 68 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways