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Protein

Pleckstrin homology domain-containing family A member 2

Gene

PLEKHA2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).By similarity

GO - Molecular functioni

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 2
Short name:
PH domain-containing family A member 2
Gene namesi
Name:PLEKHA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538751 – 425Pleckstrin homology domain-containing family A member 2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei184PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3ZBA3
PRIDEiQ3ZBA3

Interactioni

Subunit structurei

Binds MPDZ and PTPN13.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000031440

Structurei

3D structure databases

ProteinModelPortaliQ3ZBA3
SMRiQ3ZBA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 113PH 1PROSITE-ProRule annotationAdd BLAST107
Domaini198 – 298PH 2PROSITE-ProRule annotationAdd BLAST101

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF2M Eukaryota
ENOG410ZQEQ LUCA
HOGENOMiHOG000116175
HOVERGENiHBG053612
InParanoidiQ3ZBA3

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00233 PH, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 2 hits

Sequencei

Sequence statusi: Complete.

Q3ZBA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYVDRQNRI CGFLDIEENE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA
60 70 80 90 100
IGAGAVGSLQ LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD
110 120 130 140 150
LKDWVEALNQ ASKITVPKAG NLPLTTEVLK SLATPLALEK KPQVAYKTEI
160 170 180 190 200
IGGVVVHTPI NQNGGDGQEV GEPGSHAILR RSQSYIPTTG CRGPTGPPLI
210 220 230 240 250
KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR TIFLKDVLKT
260 270 280 290 300
HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL
310 320 330 340 350
KCHPREMSFS RSISLTRPGS SSLSGGPNSI LCRGRAPGEE RKTLCKAPSL
360 370 380 390 400
ASSWQPWTPV PQAGEKLLPT EETAEDSLFT PRLGESSTSA VLPSSRIRHR
410 420
SEPQHPKEKP FVFNLDDENI RTSDV
Length:425
Mass (Da):47,432
Last modified:September 27, 2005 - v1
Checksum:iB54FAE4CC8CAEFA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103474 mRNA Translation: AAI03475.1
RefSeqiNP_001030460.1, NM_001035383.1
UniGeneiBt.22283

Genome annotation databases

GeneIDi530879
KEGGibta:530879

Entry informationi

Entry nameiPKHA2_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: September 27, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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