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Protein

Tectonin beta-propeller repeat-containing protein 1

Gene

Tecpr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tectonin beta-propeller repeat-containing protein 1
Gene namesi
Name:Tecpr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1306873. Tecpr1.

Subcellular locationi

  • Cytoplasmic vesicleautophagosome membrane By similarity
  • Lysosome membrane By similarity

  • Note: Localizes to Lysosome membranes, and binds PtdIns3P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11661166Tectonin beta-propeller repeat-containing protein 1PRO_0000337063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei386 – 3861PhosphoserineBy similarity
Modified residuei388 – 3881PhosphoserineBy similarity
Modified residuei391 – 3911PhosphoserineBy similarity
Modified residuei413 – 4131PhosphoserineBy similarity
Modified residuei418 – 4181PhosphoserineBy similarity
Modified residuei943 – 9431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3ZBA0.
PRIDEiQ3ZBA0.

PTM databases

iPTMnetiQ3ZBA0.
PhosphoSiteiQ3ZBA0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001010.
GenevisibleiQ3ZBA0. RN.

Interactioni

Subunit structurei

Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001347.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati209 – 24032TECPR 1Add
BLAST
Repeati254 – 28532TECPR 2Add
BLAST
Repeati301 – 33232TECPR 3Add
BLAST
Repeati344 – 37633TECPR 4Add
BLAST
Domaini616 – 722107PHAdd
BLAST
Repeati734 – 76128TECPR 5Add
BLAST
Repeati958 – 98932TECPR 6Add
BLAST
Repeati1003 – 103432TECPR 7Add
BLAST
Repeati1049 – 108032TECPR 8Add
BLAST
Repeati1092 – 113241TECPR 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi384 – 3918Poly-Ser

Domaini

The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns3P).By similarity

Sequence similaritiesi

Belongs to the TECPR1 family.Curated
Contains 1 PH domain.Curated
Contains 9 TECPR repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3669. Eukaryota.
ENOG410YE4N. LUCA.
GeneTreeiENSGT00510000047886.
HOGENOMiHOG000007892.
InParanoidiQ3ZBA0.
KOiK17988.
OMAiYLGLEFK.
OrthoDBiEOG091G00J5.
PhylomeDBiQ3ZBA0.
TreeFamiTF323648.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR006624. Beta-propeller_rpt_TECPR.
IPR010482. Peroxin.
IPR006614. Peroxin/Ferlin.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF06462. Hyd_WA. 8 hits.
PF06398. Pex24p. 2 hits.
[Graphical view]
SMARTiSM00694. DysFC. 2 hits.
SM00693. DysFN. 2 hits.
SM00706. TECPR. 11 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZBA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTSMLWAVD LFGRVYTLST AGQYWELCKD VQLEFKRVSA ATQCCWGIAC
60 70 80 90 100
DNQVYLYVCS SDVPIRHREE AYENQRWNPM GGFCEKLLPS DRWSWSDVSG
110 120 130 140 150
LQHRPLDGVA LPSPYWEWES DWYVDENFGG EPTEKGGWTY AMDFPATYTR
160 170 180 190 200
DKKWNSCVRR RKWIRYRRYK SRDTWAKIPS KDDPKELPDP FNDLSVGGWE
210 220 230 240 250
ITEEPVGRLS VWAVSLQGKV WYRENVSHPN PEGSSWSLVD TPGEVVQISC
260 270 280 290 300
GPHDLIWATL WEGQALVREG ICRNNPKGNS WSIVEPPGSE NGIMHVSAGV
310 320 330 340 350
SVVWAITKDR KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GLNDQVWGIS
360 370 380 390 400
CEDRAVYFRQ GVTPSELSGK TWKAIVVGRE SDRSHSGSSS SLLSAGCFFG
410 420 430 440 450
EEVRGSGTES APSDTDASSE VERQGPERSL PKESLDNSRN LKGSSSKGHE
460 470 480 490 500
STRNTEDPME NACLAEGQAK APKTSGPDEC HGPAPTPAEL PWTNIDLKEP
510 520 530 540 550
KKASNQPAAG FPETSGLSSL GLFPMGMEEP YGADDHPLWA WVSGGGCAVE
560 570 580 590 600
AGSALKWFTV QSGLSPSVQT LSLSITPAQT AAWRKQIFQQ LTERTKRELE
610 620 630 640 650
SFRHYEQAVE QSVWVKTGAL QWWCDWKPHK WVDVRVALEQ FTGHDGARDS
660 670 680 690 700
ILFIYYVVHE EKKYLHVFLN EVTVLVPVLN EAKHSFALYT PERTRQRWPV
710 720 730 740 750
RLAATTEQDM NDWLTLLSLS CCESRKVHGR PSLQAIWSVT CKGDIFVSEP
760 770 780 790 800
SPDLEAHEHL LPCDQMFWRQ MGGHLRIIEA NSRGVVWGIG YDHTAWVYTG
810 820 830 840 850
GYGGGCFQGL ASSTSNIYTQ SDVKSVYIYE NQRWNPVTGY TSRGLPTDRY
860 870 880 890 900
MWSDVTGLQE CTKAGTKPPS LQWTWVSDWY VDFSVLGGTD QEGWQYASDF
910 920 930 940 950
PASYHGYKTM KDFVRRRCWA RKCKLVTSGP WLEVAPIALS DVSIIPESAD
960 970 980 990 1000
ANGRGHNIAL WAVSDKGDVL CRLGVSELNP AGSSWLHVGT DQPFASVSIG
1010 1020 1030 1040 1050
ACYQVWAVAR DGSAFYRGSV SPSQPAGDCW YHIPSPPKQK LTQVSVGQTS
1060 1070 1080 1090 1100
VYALDENGNL WYRAGITPSY PQGSSWEHVS NNVRKVSVGP LDQVWVIANK
1110 1120 1130 1140 1150
VQGSHGLSRG TVCRRMGVQP REPKGQGWDY GIGGGWDHIS VRANATRAPR
1160
NMSRDQEAHG PGPVCC
Length:1,166
Mass (Da):130,187
Last modified:September 27, 2005 - v1
Checksum:iF7CB6872B2F93BBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103478 mRNA. Translation: AAI03479.1.
RefSeqiNP_001032268.1. NM_001037191.1.
UniGeneiRn.162096.

Genome annotation databases

EnsembliENSRNOT00000001347; ENSRNOP00000001347; ENSRNOG00000001010.
GeneIDi304285.
KEGGirno:304285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103478 mRNA. Translation: AAI03479.1.
RefSeqiNP_001032268.1. NM_001037191.1.
UniGeneiRn.162096.

3D structure databases

ProteinModelPortaliQ3ZBA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001347.

PTM databases

iPTMnetiQ3ZBA0.
PhosphoSiteiQ3ZBA0.

Proteomic databases

PaxDbiQ3ZBA0.
PRIDEiQ3ZBA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001347; ENSRNOP00000001347; ENSRNOG00000001010.
GeneIDi304285.
KEGGirno:304285.

Organism-specific databases

CTDi25851.
RGDi1306873. Tecpr1.

Phylogenomic databases

eggNOGiKOG3669. Eukaryota.
ENOG410YE4N. LUCA.
GeneTreeiENSGT00510000047886.
HOGENOMiHOG000007892.
InParanoidiQ3ZBA0.
KOiK17988.
OMAiYLGLEFK.
OrthoDBiEOG091G00J5.
PhylomeDBiQ3ZBA0.
TreeFamiTF323648.

Miscellaneous databases

PROiQ3ZBA0.

Gene expression databases

BgeeiENSRNOG00000001010.
GenevisibleiQ3ZBA0. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR006624. Beta-propeller_rpt_TECPR.
IPR010482. Peroxin.
IPR006614. Peroxin/Ferlin.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF06462. Hyd_WA. 8 hits.
PF06398. Pex24p. 2 hits.
[Graphical view]
SMARTiSM00694. DysFC. 2 hits.
SM00693. DysFN. 2 hits.
SM00706. TECPR. 11 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCPR1_RAT
AccessioniPrimary (citable) accession number: Q3ZBA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 27, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.