Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Hrh2 protein

Gene

Hrh2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: GO_Central
  • digestive tract development Source: MGI
  • epithelial cell morphogenesis Source: MGI
  • gastric acid secretion Source: MGI
  • gastrin-induced gastric acid secretion Source: MGI
  • gland development Source: MGI
  • histamine-induced gastric acid secretion Source: MGI
  • immune response Source: GO_Central
  • memory Source: MGI
  • phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of vasoconstriction Source: InterPro
  • regulation of synaptic plasticity Source: MGI
  • sensory perception of chemical stimulus Source: GO_Central
  • synaptic transmission, dopaminergic Source: GO_Central
  • toxin transport Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Hrh2 proteinImported
Gene namesi
Name:Hrh2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:108482. Hrh2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiQ3ZB30. baseline and differential.
GenevestigatoriQ3ZB30.

Structurei

3D structure databases

ProteinModelPortaliQ3ZB30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOVERGENiHBG106962.
KOiK04150.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3ZB30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EPNGTVHSCC LDSIALKVTI SVVLTTLIFI TVAGNVVVCL AVSLNRRLRS
60 70 80 90 100
LTNCFIVSLA ATDLLLGLLV MPFSAIYQLS FKWSFGQVFC NIYTSLDVML
110 120 130 140 150
CTASILNLFM ISLDRYCAVT DPLRYPVLVT PVRVAISLVF IWVISITLSF
160 170 180 190 200
LSIHLGWNSR NGTRGGNDTF KCKVQVNEVY GLVDGMVTFY LPLLIMCVTY
210 220 230 240 250
YRIFKIAREQ AKRINHISSW KAATIREHKA TVTLAAVMGA FIVCWFPYFT
260 270 280 290 300
AFVYRGLRGD DAVNEVVEGI VLWLGYANSA LNPILYATLN RDFRMAYQQL
310 320 330 340 350
FHCKLASHNS HKTSLRLNNS LLSRSQSREG RWQEEKPLKL QVWSGTELTH

PQGSPVR
Length:357
Mass (Da):40,153
Last modified:September 27, 2005 - v1
Checksum:i6F128006616957AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103553 mRNA. Translation: AAI03554.1.
BC103554 mRNA. Translation: AAI03555.1.
RefSeqiNP_032312.2. NM_008286.2.
UniGeneiMm.57243.

Genome annotation databases

GeneIDi15466.
KEGGimmu:15466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103553 mRNA. Translation: AAI03554.1.
BC103554 mRNA. Translation: AAI03555.1.
RefSeqiNP_032312.2. NM_008286.2.
UniGeneiMm.57243.

3D structure databases

ProteinModelPortaliQ3ZB30.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

DNASUi15466.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15466.
KEGGimmu:15466.

Organism-specific databases

CTDi3274.
MGIiMGI:108482. Hrh2.

Phylogenomic databases

HOVERGENiHBG106962.
KOiK04150.

Miscellaneous databases

NextBioi288294.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ3ZB30. baseline and differential.
GenevestigatoriQ3ZB30.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiQ3ZB30_MOUSE
AccessioniPrimary (citable) accession number: Q3ZB30
Entry historyi
Integrated into UniProtKB/TrEMBL: September 27, 2005
Last sequence update: September 27, 2005
Last modified: May 27, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.