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Protein

Enhancer of mRNA-decapping protein 4

Gene

Edc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro) (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-RNO-430039. mRNA decay by 5' to 3' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 4
Gene namesi
Name:Edc4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1562009. Edc4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002789642 – 1407Enhancer of mRNA-decapping protein 4Add BLAST1406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei125N6-acetyllysineBy similarity1
Modified residuei560PhosphoserineBy similarity1
Modified residuei565PhosphoserineBy similarity1
Modified residuei583PhosphoserineBy similarity1
Modified residuei585PhosphoserineBy similarity1
Modified residuei681PhosphoserineBy similarity1
Modified residuei713PhosphoserineBy similarity1
Modified residuei728PhosphoserineBy similarity1
Modified residuei730PhosphoserineBy similarity1
Modified residuei732PhosphothreonineBy similarity1
Modified residuei734PhosphoserineCombined sources1
Modified residuei746PhosphoserineBy similarity1
Modified residuei827PhosphothreonineBy similarity1
Modified residuei850PhosphoserineCombined sources1
Modified residuei877PhosphoserineBy similarity1
Modified residuei880PhosphothreonineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei885PhosphoserineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei896PhosphoserineBy similarity1
Modified residuei898PhosphoserineBy similarity1
Modified residuei907PhosphothreonineBy similarity1
Modified residuei1386PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3ZAV8.
PRIDEiQ3ZAV8.

PTM databases

iPTMnetiQ3ZAV8.
PhosphoSitePlusiQ3ZAV8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000024025.
ExpressionAtlasiQ3ZAV8. differential.
GenevisibleiQ3ZAV8. RN.

Interactioni

Subunit structurei

Part of a decapping complex consisting of DCP1A, DCP2, EDC3, EDC4 and probably DDX6. Part of a complex consisting of DCP1A, EDC3, EDC4 and DDX6. Part of a complex consisting of DCP1B, EDC3, EDC4 and DDX6. Interacts with DCP2 (By similarity). Interacts with RC3H1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3ZAV8. 1 interactor.
STRINGi10116.ENSRNOP00000033608.

Structurei

3D structure databases

ProteinModelPortaliQ3ZAV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati174 – 214WD 1Add BLAST41
Repeati230 – 277WD 2Add BLAST48
Repeati295 – 334WD 3Add BLAST40
Repeati342 – 393WD 4Add BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili972 – 1031Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi609 – 684Ser-richAdd BLAST76

Sequence similaritiesi

Belongs to the WD repeat EDC4 family.Curated
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1916. Eukaryota.
ENOG410XP6V. LUCA.
GeneTreeiENSGT00510000047791.
HOGENOMiHOG000013082.
HOVERGENiHBG053855.
InParanoidiQ3ZAV8.
KOiK12616.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR032401. EDC4_WD40.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16529. Ge1_WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZAV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASCASIDIE DATQHLRDIL KLDRPAGGSN VESQRPSSAY NGDLNGLLVP
60 70 80 90 100
DPLSSGDGNS TSKPGIRTMP PINLQEKQVI CLSGDDSSTC IGILAKEVEI
110 120 130 140 150
VASSDSSISS KARGSNKVKI QPVAKYDWEQ KYYYGNLIAV SNSFLAYAIR
160 170 180 190 200
AANNGSAMVR VISVSTSERT LLKGFTGSVA DLAFAHLNSP QLACLDEAGD
210 220 230 240 250
LFVWRLALVK GKIQEEILVH IRQPEGTPLN HFRRIIWCPF IPEESEDCCE
260 270 280 290 300
ESSPTVALLH EDRAEVWDLD MLRSSHSTWP VDVSQIKQGF IVVKGHSTCL
310 320 330 340 350
SEGALSPDGT VLATASHDGF VKFWQIYIEG QDEPRCLHEW KPHDGRPLSC
360 370 380 390 400
LLFCDNHKKQ DPEVPFWRFL ITGADQNREL KMWCTVSWTC LQTIRFSPDI
410 420 430 440 450
FSSVSVPPSL KVCLDLSAEY LILSDVQRKV LYVMELLQNQ DEGRACFSSI
460 470 480 490 500
SEFLLTHPVL SFGIQVVSRC RLRHTEVLPA EEESDSLGTE SSHGAGTLES
510 520 530 540 550
AAGVLIKLFC VHTKALQDVQ IRFQPQLNPD VVAPLSTHTA HEDFTFGESR
560 570 580 590 600
PELGSEGLAS APHGSQPDLR RIVELPAPAD FLSLSSETKP KLMTPDAFMT
610 620 630 640 650
PTASLQQISA SPSSSSSSSS SSSSSSSSSS SSSLTAVSAV SSSSAMDPSL
660 670 680 690 700
PSRPPEELTL SPKLQLDGSL TISSSSSLQA SPRSLLPGLL PGPADKLIPK
710 720 730 740 750
GPGQVSSGTS ALSLDLQEVE PLGLPQASPS RTRSPDVISS ASTALSQDIP
760 770 780 790 800
EIASEALSRG FGSSVPEGLI EPDSMASAAS ALHLLSPRPR QGPELSSQLG
810 820 830 840 850
LDGGPGDGDR HSTPSLLEAA LTQEVATSDS QVWPTAPDIT RETCSTLTES
860 870 880 890 900
PRNGLQEKHK SLAFHRPPYH LLQQHDSQDT SAEQSDHDDE VASLASASGG
910 920 930 940 950
FGSKIPTPRL PAKDWKTKGS PRTSPKLKRK SKKDDGDSAV GSRLTEHQVV
960 970 980 990 1000
EPPEDWPALI WQQQRELAEL WHNQEELLQR LCAQLEGLQS TVTDHVERAL
1010 1020 1030 1040 1050
ETRHEQEQRR LERALAEGQQ RGGQLQEQLT QQLSQALSSA VAGRLERSIR
1060 1070 1080 1090 1100
DEIKKTVPPC VSRSLEPVAG QLSNSVATKL TAVEGSMKEN ISKLLKSKNL
1110 1120 1130 1140 1150
TDAIARAAAD TLQGPMQAAY REAFQSVVLP AFEKSCQAMF QQINDSFRLG
1160 1170 1180 1190 1200
TQEYLQQLDS HMKSRKAREQ EAREPVLAQL RGLVSTLQNA TEQMAATVSS
1210 1220 1230 1240 1250
SVRAEVQHQL HVAVGSLQES ILAQVQRIVK GEVSVALKEQ QATVTSSIMQ
1260 1270 1280 1290 1300
AMRSAAGTPV PSAHLDCQAQ QAHILQLLQQ GHLNQAFQQA LTAADLNLVL
1310 1320 1330 1340 1350
YVCETVDPAQ VFGQPPCPLS QPVLLSLIQQ LASDLGTRSD LKLSYLEEAV
1360 1370 1380 1390 1400
MHLDHSDPIT RDHMGSVMAQ VRQKLFQFLQ ADPHNSLGKA ARRLSLMLHG

LVTPSLP
Length:1,407
Mass (Da):152,596
Last modified:September 27, 2005 - v1
Checksum:iE9C551C47D199EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103628 mRNA. Translation: AAI03629.1.
RefSeqiNP_001028240.3. NM_001033068.3.
UniGeneiRn.145173.

Genome annotation databases

EnsembliENSRNOT00000030967; ENSRNOP00000033608; ENSRNOG00000024025.
GeneIDi361399.
KEGGirno:361399.
UCSCiRGD:1562009. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103628 mRNA. Translation: AAI03629.1.
RefSeqiNP_001028240.3. NM_001033068.3.
UniGeneiRn.145173.

3D structure databases

ProteinModelPortaliQ3ZAV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3ZAV8. 1 interactor.
STRINGi10116.ENSRNOP00000033608.

PTM databases

iPTMnetiQ3ZAV8.
PhosphoSitePlusiQ3ZAV8.

Proteomic databases

PaxDbiQ3ZAV8.
PRIDEiQ3ZAV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030967; ENSRNOP00000033608; ENSRNOG00000024025.
GeneIDi361399.
KEGGirno:361399.
UCSCiRGD:1562009. rat.

Organism-specific databases

CTDi23644.
RGDi1562009. Edc4.

Phylogenomic databases

eggNOGiKOG1916. Eukaryota.
ENOG410XP6V. LUCA.
GeneTreeiENSGT00510000047791.
HOGENOMiHOG000013082.
HOVERGENiHBG053855.
InParanoidiQ3ZAV8.
KOiK12616.

Enzyme and pathway databases

ReactomeiR-RNO-430039. mRNA decay by 5' to 3' exoribonuclease.

Miscellaneous databases

PROiQ3ZAV8.

Gene expression databases

BgeeiENSRNOG00000024025.
ExpressionAtlasiQ3ZAV8. differential.
GenevisibleiQ3ZAV8. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR032401. EDC4_WD40.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF16529. Ge1_WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDC4_RAT
AccessioniPrimary (citable) accession number: Q3ZAV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 27, 2005
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.