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Q3ZAV1

- S22AC_RAT

UniProt

Q3ZAV1 - S22AC_RAT

Protein

Solute carrier family 22 member 12

Gene

Slc22a12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions By similarity.By similarity

    GO - Molecular functioni

    1. PDZ domain binding Source: UniProtKB
    2. urate transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. organic acid transport Source: GOC
    2. response to drug Source: UniProtKB
    3. urate metabolic process Source: Ensembl
    4. urate transport Source: UniProtKB

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196407. Organic anion transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 12
    Alternative name(s):
    Urate anion exchanger 1
    Gene namesi
    Name:Slc22a12
    Synonyms:Urat1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621628. Slc22a12.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein
    Note: Detected in the luminal membrane of the epithelium of renal proximal tubules.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. brush border membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Solute carrier family 22 member 12PRO_0000307946Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ3ZAV1.
    PRIDEiQ3ZAV1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3ZAV1.

    Interactioni

    Subunit structurei

    Interacts with PDZK1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028665.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZAV1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00750000117657.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ3ZAV1.
    KOiK08208.
    OMAiPIMWLTT.
    OrthoDBiEOG7NW68T.
    PhylomeDBiQ3ZAV1.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3ZAV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFPELLDRV GGRGRFQLLQ AVALVTPILW VTTQNMLENF SAAVPHHRCW    50
    VPLLDNSTSQ ASIPGDFGRD VLLAVSIPPG PDQRPHQCLR FRQPQWQLIE 100
    SNTTATNWSD ADTEPCEDGW VYDHSTFRST IVTTWDLVCD SQALRPMAQS 150
    IFLAGILVGA AVCGHASDRF GRRRVLTWSY LLVSVSGTIA ALMPTFPLYC 200
    LFRFLVASAV AGVMMNTASL LMEWTSAQAG PLMMTLNALG FSFGQVLTGS 250
    VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG RLDQSLRELQ 300
    RVAAVNRRKA EADTLTVEVL RSAMQEEPNG NQAGARLGTL LHTPGLRLRT 350
    FISMLCWFAF GFTFYGLALD LQALGSNIFL LQALIGIVDL PVKMGSLLLL 400
    SRLGRRLCQA SSLVLPGLCI LANILVPREM GILRSSLAVL GLGSLGAAFT 450
    CVTIFSSELF PTVIRMTAVG LGQVAARGGA MLGPLVRLLG VYGSWLPLLV 500
    YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH DIAGGSVLKS 550
    ARL 553
    Length:553
    Mass (Da):60,245
    Last modified:September 27, 2005 - v1
    Checksum:iA264F7CFD937CCD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103638 mRNA. Translation: AAI03639.1.
    RefSeqiNP_001030115.1. NM_001034943.1.
    UniGeneiRn.137035.

    Genome annotation databases

    EnsembliENSRNOT00000028665; ENSRNOP00000028665; ENSRNOG00000021108.
    GeneIDi365398.
    KEGGirno:365398.
    UCSCiRGD:621628. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103638 mRNA. Translation: AAI03639.1 .
    RefSeqi NP_001030115.1. NM_001034943.1.
    UniGenei Rn.137035.

    3D structure databases

    ProteinModelPortali Q3ZAV1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028665.

    Chemistry

    ChEMBLi CHEMBL1075239.

    Proteomic databases

    PaxDbi Q3ZAV1.
    PRIDEi Q3ZAV1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028665 ; ENSRNOP00000028665 ; ENSRNOG00000021108 .
    GeneIDi 365398.
    KEGGi rno:365398.
    UCSCi RGD:621628. rat.

    Organism-specific databases

    CTDi 116085.
    RGDi 621628. Slc22a12.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00750000117657.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q3ZAV1.
    KOi K08208.
    OMAi PIMWLTT.
    OrthoDBi EOG7NW68T.
    PhylomeDBi Q3ZAV1.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_196407. Organic anion transport.

    Miscellaneous databases

    NextBioi 687376.
    PROi Q3ZAV1.

    Gene expression databases

    Genevestigatori Q3ZAV1.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiS22AC_RAT
    AccessioniPrimary (citable) accession number: Q3ZAV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3