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Protein

Solute carrier family 22 member 12

Gene

Slc22a12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to insulin stimulus Source: RGD
  • response to drug Source: UniProtKB
  • sodium-independent organic anion transport Source: GO_Central
  • urate salt excretion Source: RGD
  • urate transport Source: UniProtKB

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-561048 Organic anion transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 12
Alternative name(s):
Urate anion exchanger 1
Gene namesi
Name:Slc22a12
Synonyms:Urat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621628 Slc22a12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075239

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079461 – 553Solute carrier family 22 member 12Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei534PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3ZAV1
PRIDEiQ3ZAV1

PTM databases

iPTMnetiQ3ZAV1
PhosphoSitePlusiQ3ZAV1

Expressioni

Gene expression databases

BgeeiENSRNOG00000021108
ExpressionAtlasiQ3ZAV1 baseline and differential
GenevisibleiQ3ZAV1 RN

Interactioni

Subunit structurei

Interacts with PDZK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028665

Chemistry databases

BindingDBiQ3ZAV1

Structurei

3D structure databases

ProteinModelPortaliQ3ZAV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ3ZAV1
KOiK08208
OrthoDBiEOG091G068G
PhylomeDBiQ3ZAV1
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZAV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPELLDRV GGRGRFQLLQ AVALVTPILW VTTQNMLENF SAAVPHHRCW
60 70 80 90 100
VPLLDNSTSQ ASIPGDFGRD VLLAVSIPPG PDQRPHQCLR FRQPQWQLIE
110 120 130 140 150
SNTTATNWSD ADTEPCEDGW VYDHSTFRST IVTTWDLVCD SQALRPMAQS
160 170 180 190 200
IFLAGILVGA AVCGHASDRF GRRRVLTWSY LLVSVSGTIA ALMPTFPLYC
210 220 230 240 250
LFRFLVASAV AGVMMNTASL LMEWTSAQAG PLMMTLNALG FSFGQVLTGS
260 270 280 290 300
VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG RLDQSLRELQ
310 320 330 340 350
RVAAVNRRKA EADTLTVEVL RSAMQEEPNG NQAGARLGTL LHTPGLRLRT
360 370 380 390 400
FISMLCWFAF GFTFYGLALD LQALGSNIFL LQALIGIVDL PVKMGSLLLL
410 420 430 440 450
SRLGRRLCQA SSLVLPGLCI LANILVPREM GILRSSLAVL GLGSLGAAFT
460 470 480 490 500
CVTIFSSELF PTVIRMTAVG LGQVAARGGA MLGPLVRLLG VYGSWLPLLV
510 520 530 540 550
YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH DIAGGSVLKS

ARL
Length:553
Mass (Da):60,245
Last modified:September 27, 2005 - v1
Checksum:iA264F7CFD937CCD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103638 mRNA Translation: AAI03639.1
RefSeqiNP_001030115.1, NM_001034943.1
XP_008758383.1, XM_008760161.2
XP_008758384.1, XM_008760162.2
UniGeneiRn.137035

Genome annotation databases

EnsembliENSRNOT00000092270; ENSRNOP00000075925; ENSRNOG00000021108
GeneIDi365398
KEGGirno:365398
UCSCiRGD:621628 rat

Similar proteinsi

Entry informationi

Entry nameiS22AC_RAT
AccessioniPrimary (citable) accession number: Q3ZAV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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