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Protein

Solute carrier family 22 member 12

Gene

Slc22a12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_326944. Organic anion transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 12
Alternative name(s):
Urate anion exchanger 1
Gene namesi
Name:Slc22a12
Synonyms:Urat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621628. Slc22a12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST
Transmembranei435 – 45521HelicalSequence AnalysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence AnalysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 22 member 12PRO_0000307946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3ZAV1.
PRIDEiQ3ZAV1.

Expressioni

Gene expression databases

GenevisibleiQ3ZAV1. RN.

Interactioni

Subunit structurei

Interacts with PDZK1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028665.

Structurei

3D structure databases

ProteinModelPortaliQ3ZAV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ3ZAV1.
KOiK08208.
OMAiRISCCIT.
OrthoDBiEOG7NW68T.
PhylomeDBiQ3ZAV1.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZAV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPELLDRV GGRGRFQLLQ AVALVTPILW VTTQNMLENF SAAVPHHRCW
60 70 80 90 100
VPLLDNSTSQ ASIPGDFGRD VLLAVSIPPG PDQRPHQCLR FRQPQWQLIE
110 120 130 140 150
SNTTATNWSD ADTEPCEDGW VYDHSTFRST IVTTWDLVCD SQALRPMAQS
160 170 180 190 200
IFLAGILVGA AVCGHASDRF GRRRVLTWSY LLVSVSGTIA ALMPTFPLYC
210 220 230 240 250
LFRFLVASAV AGVMMNTASL LMEWTSAQAG PLMMTLNALG FSFGQVLTGS
260 270 280 290 300
VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG RLDQSLRELQ
310 320 330 340 350
RVAAVNRRKA EADTLTVEVL RSAMQEEPNG NQAGARLGTL LHTPGLRLRT
360 370 380 390 400
FISMLCWFAF GFTFYGLALD LQALGSNIFL LQALIGIVDL PVKMGSLLLL
410 420 430 440 450
SRLGRRLCQA SSLVLPGLCI LANILVPREM GILRSSLAVL GLGSLGAAFT
460 470 480 490 500
CVTIFSSELF PTVIRMTAVG LGQVAARGGA MLGPLVRLLG VYGSWLPLLV
510 520 530 540 550
YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH DIAGGSVLKS

ARL
Length:553
Mass (Da):60,245
Last modified:September 27, 2005 - v1
Checksum:iA264F7CFD937CCD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103638 mRNA. Translation: AAI03639.1.
RefSeqiNP_001030115.1. NM_001034943.1.
XP_008758383.1. XM_008760161.1.
XP_008758384.1. XM_008760162.1.
UniGeneiRn.137035.

Genome annotation databases

EnsembliENSRNOT00000028665; ENSRNOP00000028665; ENSRNOG00000021108.
GeneIDi365398.
KEGGirno:365398.
UCSCiRGD:621628. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103638 mRNA. Translation: AAI03639.1.
RefSeqiNP_001030115.1. NM_001034943.1.
XP_008758383.1. XM_008760161.1.
XP_008758384.1. XM_008760162.1.
UniGeneiRn.137035.

3D structure databases

ProteinModelPortaliQ3ZAV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028665.

Chemistry

BindingDBiQ3ZAV1.
ChEMBLiCHEMBL1075239.

Proteomic databases

PaxDbiQ3ZAV1.
PRIDEiQ3ZAV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028665; ENSRNOP00000028665; ENSRNOG00000021108.
GeneIDi365398.
KEGGirno:365398.
UCSCiRGD:621628. rat.

Organism-specific databases

CTDi116085.
RGDi621628. Slc22a12.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ3ZAV1.
KOiK08208.
OMAiRISCCIT.
OrthoDBiEOG7NW68T.
PhylomeDBiQ3ZAV1.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiREACT_326944. Organic anion transport.

Miscellaneous databases

NextBioi687376.
PROiQ3ZAV1.

Gene expression databases

GenevisibleiQ3ZAV1. RN.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS22AC_RAT
AccessioniPrimary (citable) accession number: Q3ZAV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 27, 2005
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.