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Q3ZAV1 (S22AC_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 12
Alternative name(s):
Urate anion exchanger 1
Gene names
Name:Slc22a12
Synonyms:Urat1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions By similarity.

Subunit structure

Interacts with PDZK1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Detected in the luminal membrane of the epithelium of renal proximal tubules By similarity.

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Solute carrier family 22 member 12
PRO_0000307946

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane260 – 28021Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane378 – 39821Helical; Potential
Transmembrane407 – 42721Helical; Potential
Transmembrane435 – 45521Helical; Potential
Transmembrane466 – 48621Helical; Potential
Transmembrane495 – 51521Helical; Potential

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1071N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q3ZAV1 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: A264F7CFD937CCD8

FASTA55360,245
        10         20         30         40         50         60 
MAFPELLDRV GGRGRFQLLQ AVALVTPILW VTTQNMLENF SAAVPHHRCW VPLLDNSTSQ 

        70         80         90        100        110        120 
ASIPGDFGRD VLLAVSIPPG PDQRPHQCLR FRQPQWQLIE SNTTATNWSD ADTEPCEDGW 

       130        140        150        160        170        180 
VYDHSTFRST IVTTWDLVCD SQALRPMAQS IFLAGILVGA AVCGHASDRF GRRRVLTWSY 

       190        200        210        220        230        240 
LLVSVSGTIA ALMPTFPLYC LFRFLVASAV AGVMMNTASL LMEWTSAQAG PLMMTLNALG 

       250        260        270        280        290        300 
FSFGQVLTGS VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG RLDQSLRELQ 

       310        320        330        340        350        360 
RVAAVNRRKA EADTLTVEVL RSAMQEEPNG NQAGARLGTL LHTPGLRLRT FISMLCWFAF 

       370        380        390        400        410        420 
GFTFYGLALD LQALGSNIFL LQALIGIVDL PVKMGSLLLL SRLGRRLCQA SSLVLPGLCI 

       430        440        450        460        470        480 
LANILVPREM GILRSSLAVL GLGSLGAAFT CVTIFSSELF PTVIRMTAVG LGQVAARGGA 

       490        500        510        520        530        540 
MLGPLVRLLG VYGSWLPLLV YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH 

       550 
DIAGGSVLKS ARL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC103638 mRNA. Translation: AAI03639.1.
RefSeqNP_001030115.1. NM_001034943.1.
UniGeneRn.137035.

3D structure databases

ProteinModelPortalQ3ZAV1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000028665.

Chemistry

ChEMBLCHEMBL1075239.

Proteomic databases

PaxDbQ3ZAV1.
PRIDEQ3ZAV1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028665; ENSRNOP00000028665; ENSRNOG00000021108.
GeneID365398.
KEGGrno:365398.
UCSCRGD:621628. rat.

Organism-specific databases

CTD116085.
RGD621628. Slc22a12.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00750000117657.
HOGENOMHOG000234569.
HOVERGENHBG108433.
InParanoidQ3ZAV1.
KOK08208.
OMAPIMWLTT.
OrthoDBEOG7NW68T.
PhylomeDBQ3ZAV1.
TreeFamTF315847.

Gene expression databases

GenevestigatorQ3ZAV1.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio687376.
PROQ3ZAV1.

Entry information

Entry nameS22AC_RAT
AccessionPrimary (citable) accession number: Q3ZAV1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families