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Q3ZAV1

- S22AC_RAT

UniProt

Q3ZAV1 - S22AC_RAT

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Protein

Solute carrier family 22 member 12

Gene
Slc22a12, Urat1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions By similarity.

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. urate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. organic acid transport Source: GOC
  2. response to drug Source: UniProtKB
  3. urate metabolic process Source: Ensembl
  4. urate transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_196407. Organic anion transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 12
Alternative name(s):
Urate anion exchanger 1
Gene namesi
Name:Slc22a12
Synonyms:Urat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi621628. Slc22a12.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Detected in the luminal membrane of the epithelium of renal proximal tubules By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed predictionAdd
BLAST
Transmembranei146 – 16621Helical; Reviewed predictionAdd
BLAST
Transmembranei182 – 20221Helical; Reviewed predictionAdd
BLAST
Transmembranei204 – 22421Helical; Reviewed predictionAdd
BLAST
Transmembranei232 – 25221Helical; Reviewed predictionAdd
BLAST
Transmembranei260 – 28021Helical; Reviewed predictionAdd
BLAST
Transmembranei351 – 37121Helical; Reviewed predictionAdd
BLAST
Transmembranei378 – 39821Helical; Reviewed predictionAdd
BLAST
Transmembranei407 – 42721Helical; Reviewed predictionAdd
BLAST
Transmembranei435 – 45521Helical; Reviewed predictionAdd
BLAST
Transmembranei466 – 48621Helical; Reviewed predictionAdd
BLAST
Transmembranei495 – 51521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. brush border membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 22 member 12PRO_0000307946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3ZAV1.
PRIDEiQ3ZAV1.

Expressioni

Gene expression databases

GenevestigatoriQ3ZAV1.

Interactioni

Subunit structurei

Interacts with PDZK1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028665.

Structurei

3D structure databases

ProteinModelPortaliQ3ZAV1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00750000117657.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ3ZAV1.
KOiK08208.
OMAiPIMWLTT.
OrthoDBiEOG7NW68T.
PhylomeDBiQ3ZAV1.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZAV1-1 [UniParc]FASTAAdd to Basket

« Hide

MAFPELLDRV GGRGRFQLLQ AVALVTPILW VTTQNMLENF SAAVPHHRCW    50
VPLLDNSTSQ ASIPGDFGRD VLLAVSIPPG PDQRPHQCLR FRQPQWQLIE 100
SNTTATNWSD ADTEPCEDGW VYDHSTFRST IVTTWDLVCD SQALRPMAQS 150
IFLAGILVGA AVCGHASDRF GRRRVLTWSY LLVSVSGTIA ALMPTFPLYC 200
LFRFLVASAV AGVMMNTASL LMEWTSAQAG PLMMTLNALG FSFGQVLTGS 250
VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG RLDQSLRELQ 300
RVAAVNRRKA EADTLTVEVL RSAMQEEPNG NQAGARLGTL LHTPGLRLRT 350
FISMLCWFAF GFTFYGLALD LQALGSNIFL LQALIGIVDL PVKMGSLLLL 400
SRLGRRLCQA SSLVLPGLCI LANILVPREM GILRSSLAVL GLGSLGAAFT 450
CVTIFSSELF PTVIRMTAVG LGQVAARGGA MLGPLVRLLG VYGSWLPLLV 500
YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH DIAGGSVLKS 550
ARL 553
Length:553
Mass (Da):60,245
Last modified:September 27, 2005 - v1
Checksum:iA264F7CFD937CCD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103638 mRNA. Translation: AAI03639.1.
RefSeqiNP_001030115.1. NM_001034943.1.
UniGeneiRn.137035.

Genome annotation databases

EnsembliENSRNOT00000028665; ENSRNOP00000028665; ENSRNOG00000021108.
GeneIDi365398.
KEGGirno:365398.
UCSCiRGD:621628. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103638 mRNA. Translation: AAI03639.1 .
RefSeqi NP_001030115.1. NM_001034943.1.
UniGenei Rn.137035.

3D structure databases

ProteinModelPortali Q3ZAV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028665.

Chemistry

ChEMBLi CHEMBL1075239.

Proteomic databases

PaxDbi Q3ZAV1.
PRIDEi Q3ZAV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028665 ; ENSRNOP00000028665 ; ENSRNOG00000021108 .
GeneIDi 365398.
KEGGi rno:365398.
UCSCi RGD:621628. rat.

Organism-specific databases

CTDi 116085.
RGDi 621628. Slc22a12.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00750000117657.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q3ZAV1.
KOi K08208.
OMAi PIMWLTT.
OrthoDBi EOG7NW68T.
PhylomeDBi Q3ZAV1.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_196407. Organic anion transport.

Miscellaneous databases

NextBioi 687376.
PROi Q3ZAV1.

Gene expression databases

Genevestigatori Q3ZAV1.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS22AC_RAT
AccessioniPrimary (citable) accession number: Q3ZAV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 27, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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