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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton donorUniRule annotation1

GO - Molecular functioni

  • orotidine-5'-phosphate decarboxylase activity Source: TIGR

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciDMCC243164:G1G45-12-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:DET0013
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000664701 – 270Orotidine 5'-phosphate decarboxylaseAdd BLAST270

Proteomic databases

PRIDEiQ3ZAI1

Interactioni

Protein-protein interaction databases

STRINGi243164.DET0013

Structurei

3D structure databases

ProteinModelPortaliQ3ZAI1
SMRiQ3ZAI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105SKN Bacteria
COG0284 LUCA
HOGENOMiHOG000245747
KOiK01591
OMAiQSAFFER
OrthoDBiPOG091H09O1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZAI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLEKLKQA GNSHNSLLCV GLDPDPKLMP VGMTALEFNR EIIAATAPFV
60 70 80 90 100
CGYKINLAFY EALGKQGWEI LSETCKLIPP ELLSIADAKR GDIGNTSKAY
110 120 130 140 150
ARAVFDELGC DGVTASPYLG YDSLEPFIEY QDKGIFILCR TSNQGSADFQ
160 170 180 190 200
MLKTEYLGQK RFLYEVVADK SLQWNRYENI GLVVGATQQE ELKKLRLSYP
210 220 230 240 250
KMPFLIPGIG AQGGDLKATV ENGTNQSGQL ALICASRGIL YARSGSEFAQ
260 270
GAAEAAKQMR DAINHYRKRF
Length:270
Mass (Da):29,786
Last modified:September 27, 2005 - v1
Checksum:i33EFBCC7B816224F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA Translation: AAW39163.1
RefSeqiWP_010935823.1, NC_002936.3

Genome annotation databases

EnsemblBacteriaiAAW39163; AAW39163; DET0013
GeneIDi3229121
KEGGidet:DET0013
PATRICifig|243164.10.peg.12

Similar proteinsi

Entry informationi

Entry nameiPYRF_DEHM1
AccessioniPrimary (citable) accession number: Q3ZAI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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