Q3ZA08 (Q3ZA08_DEHE1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase RuleBase RU003903
EC=1.5.1.2 RuleBase RU003903

Gene names

Name:	proC EMBL AAW40548.1
Ordered Locus Names:	DET0193

Organism

Dehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]

Taxonomic identifier

243164 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H. RuleBase RU003903
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. RuleBase RU003903
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family. RuleBase RU003903

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis RuleBase RU003903
Ligand	NADP RuleBase RU003903
Molecular function	Oxidoreductase RuleBase RU003903 EMBL AAW40548.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3ZA08 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: C2903CA0290CB0AA	FASTA	267	27,870
	10 20 30 40 50 60 MKIAFIGGGN MGEAILGALI QKNICPPKDI TVSEIKAERR TFLENTYGIK TTPSNPEAIK 70 80 90 100 110 120 NAEVVLLAIK PQNLAELSAG LKGKLAETQL VISIIAGATL SKLSGGLEHK AVVRVMPNTP 130 140 150 160 170 180 AMIGMGMSVW TALPAVSPAQ KEQAKSILSA MGKEIYTGKE TMLDAATAIS GSGPAYFFLF 190 200 210 220 230 240 MESLEKAAQE MGFTPEEATV LVSQTAAGSA VYAEKSGLPL AQLRKNVTSP GGTTAEAIKV 250 260 FEQAGLETTV IKAAKAAFDR SVELGKG

References

[1]

"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes." Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H. , Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F. Science 307:105-108(2005) [PubMed: 15637277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000027 Genomic DNA. Translation: AAW40548.1.
RefSeq	YP_180941.1. NC_002936.3.
3D structure databases
ProteinModelPortal	Q3ZA08.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZA08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3230513.
GenomeReviews	Gene locus DET0193 in contig CP000027_GR.
KEGG	det:DET0193.
NMPDR	fig|243164.3.peg.198.
PATRIC	21607463. VBIDehEth89364_0178.
TIGR	DET0193.
Phylogenomic databases
eggNOG	COG0345.
HOGENOM	HBG726602.
OMA	RTFNEHQ.
PhylomeDB	Q3ZA08.
ProtClustDB	CLSK837612.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q3ZA08_DEHE1

Accession

Primary (citable) accession number: Q3ZA08

Entry history

Integrated into UniProtKB/TrEMBL:	September 27, 2005
Last sequence update:	September 27, 2005
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)