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Q3ZA07

- SYL_DEHM1

UniProt

Q3ZA07 - SYL_DEHM1

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDETH243164:GJNF-194-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DET0194
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000008289: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Leucine--tRNA ligasePRO_1000199192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243164.DET0194.

Structurei

3D structure databases

ProteinModelPortaliQ3ZA07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi580 – 5845"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZA07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEKYNPQET EKKWQDKWAA DRLYHAGEDS PKPKWYSLTM FPYTSGNLHI
60 70 80 90 100
GHWYAEVPAD CFARYKRLNG FNVMRPVGFD SFGLPAENAA IKHHIHPRIW
110 120 130 140 150
TLNNVENMRR QLKTIGAMFD WDREVITCLP EYYKWTQWFF LKLYEAGLAY
160 170 180 190 200
RAKAPVNWCP SCQAVLANEQ VVDGTCWRCE TPTTRRDLEQ WFFRITNYAD
210 220 230 240 250
ELKDHDGLDW PEKITAMQRN WVGKSYGAEV SFALDCPAAP EQEIKVFTTR
260 270 280 290 300
PDTIYGVTFM VLAPEHPLVE KITTPENKAA VDEYIKKSRA CTEIERLSTE
310 320 330 340 350
REKDGVFTGA YVTNRVNGHK VPVWIGDYVL QSYGTGAVMG VPAHDERDFV
360 370 380 390 400
FAQKYDLPVI TVIAPPDYDG QPLEAAYINE GVMQNSGPFN GLPNTEGKEK
410 420 430 440 450
VCDYLAEHGW GKKTVNYKLR DWLISRQRYW GAPIPMIYCE KCGIVPVPEK
460 470 480 490 500
DLPVLLPEDV EFRSGGESPL KYNEGFVNTT CPVCGGKAKR ETDTMDTFMC
510 520 530 540 550
SSWYFLRYTS PGYDKGPFDP EKLRYWMPVD LYTGGAEHAV MHLFYSRFFT
560 570 580 590 600
KALRDMGIID FGEPFKKLFN QGIIVSNHQK MSKSKGNVVT PDNLVAEVGT
610 620 630 640 650
DAVRAYLMFV GPWDQGGEWN DSGLSGMSRW LNRVWNLFTE EYTPQTASAE
660 670 680 690 700
AERELKRTLH QTIKKITMDI ERLRFNTVVA ALMELSNSLA KFKEAAAVSA
710 720 730 740 750
ESWQNSLKTF ALMLAPVAPH IAEELWANLD MEYSIHNQSW PKWDEELAKD
760 770 780 790 800
EVITLIIQVN GKLRERLEMP AGISEDEAKE TALNSTRVKP HLQGKTPASV
810
IYVPGKLVNI VVK
Length:813
Mass (Da):92,868
Last modified:September 27, 2005 - v1
Checksum:i493634ACB295ADB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW40547.1.
RefSeqiWP_010935997.1. NC_002936.3.
YP_180942.1. NC_002936.3.

Genome annotation databases

EnsemblBacteriaiAAW40547; AAW40547; DET0194.
GeneIDi3230512.
KEGGidet:DET0194.
PATRICi21607465. VBIDehEth89364_0179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW40547.1 .
RefSeqi WP_010935997.1. NC_002936.3.
YP_180942.1. NC_002936.3.

3D structure databases

ProteinModelPortali Q3ZA07.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243164.DET0194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW40547 ; AAW40547 ; DET0194 .
GeneIDi 3230512.
KEGGi det:DET0194.
PATRICi 21607465. VBIDehEth89364_0179.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DETH243164:GJNF-194-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-2266 / KCTC 15142 / 195.

Entry informationi

Entry nameiSYL_DEHM1
AccessioniPrimary (citable) accession number: Q3ZA07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3