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Q3ZA07 (SYL_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:DET0194
OrganismDehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]
Taxonomic identifier243164 [NCBI]
Taxonomic lineageBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

Protein attributes

Sequence length813 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 813813Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000199192

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif580 – 5845"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5831ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ZA07 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 493634ACB295ADB9

FASTA81392,868
        10         20         30         40         50         60 
MAEKYNPQET EKKWQDKWAA DRLYHAGEDS PKPKWYSLTM FPYTSGNLHI GHWYAEVPAD 

        70         80         90        100        110        120 
CFARYKRLNG FNVMRPVGFD SFGLPAENAA IKHHIHPRIW TLNNVENMRR QLKTIGAMFD 

       130        140        150        160        170        180 
WDREVITCLP EYYKWTQWFF LKLYEAGLAY RAKAPVNWCP SCQAVLANEQ VVDGTCWRCE 

       190        200        210        220        230        240 
TPTTRRDLEQ WFFRITNYAD ELKDHDGLDW PEKITAMQRN WVGKSYGAEV SFALDCPAAP 

       250        260        270        280        290        300 
EQEIKVFTTR PDTIYGVTFM VLAPEHPLVE KITTPENKAA VDEYIKKSRA CTEIERLSTE 

       310        320        330        340        350        360 
REKDGVFTGA YVTNRVNGHK VPVWIGDYVL QSYGTGAVMG VPAHDERDFV FAQKYDLPVI 

       370        380        390        400        410        420 
TVIAPPDYDG QPLEAAYINE GVMQNSGPFN GLPNTEGKEK VCDYLAEHGW GKKTVNYKLR 

       430        440        450        460        470        480 
DWLISRQRYW GAPIPMIYCE KCGIVPVPEK DLPVLLPEDV EFRSGGESPL KYNEGFVNTT 

       490        500        510        520        530        540 
CPVCGGKAKR ETDTMDTFMC SSWYFLRYTS PGYDKGPFDP EKLRYWMPVD LYTGGAEHAV 

       550        560        570        580        590        600 
MHLFYSRFFT KALRDMGIID FGEPFKKLFN QGIIVSNHQK MSKSKGNVVT PDNLVAEVGT 

       610        620        630        640        650        660 
DAVRAYLMFV GPWDQGGEWN DSGLSGMSRW LNRVWNLFTE EYTPQTASAE AERELKRTLH 

       670        680        690        700        710        720 
QTIKKITMDI ERLRFNTVVA ALMELSNSLA KFKEAAAVSA ESWQNSLKTF ALMLAPVAPH 

       730        740        750        760        770        780 
IAEELWANLD MEYSIHNQSW PKWDEELAKD EVITLIIQVN GKLRERLEMP AGISEDEAKE 

       790        800        810 
TALNSTRVKP HLQGKTPASV IYVPGKLVNI VVK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000027 Genomic DNA. Translation: AAW40547.1.
RefSeqYP_180942.1. NC_002936.3.

3D structure databases

ProteinModelPortalQ3ZA07.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243164.DET0194.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW40547; AAW40547; DET0194.
GeneID3230512.
KEGGdet:DET0194.
PATRIC21607465. VBIDehEth89364_0179.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycDETH243164:GJNF-194-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_DEHE1
AccessionPrimary (citable) accession number: Q3ZA07
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 27, 2005
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries