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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei583ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDMCC243164:G1G45-195-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DET0194
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001991921 – 813Leucine--tRNA ligaseAdd BLAST813

Interactioni

Protein-protein interaction databases

STRINGi243164.DET0194

Structurei

3D structure databases

ProteinModelPortaliQ3ZA07
SMRiQ3ZA07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi580 – 584"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZA07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKYNPQET EKKWQDKWAA DRLYHAGEDS PKPKWYSLTM FPYTSGNLHI
60 70 80 90 100
GHWYAEVPAD CFARYKRLNG FNVMRPVGFD SFGLPAENAA IKHHIHPRIW
110 120 130 140 150
TLNNVENMRR QLKTIGAMFD WDREVITCLP EYYKWTQWFF LKLYEAGLAY
160 170 180 190 200
RAKAPVNWCP SCQAVLANEQ VVDGTCWRCE TPTTRRDLEQ WFFRITNYAD
210 220 230 240 250
ELKDHDGLDW PEKITAMQRN WVGKSYGAEV SFALDCPAAP EQEIKVFTTR
260 270 280 290 300
PDTIYGVTFM VLAPEHPLVE KITTPENKAA VDEYIKKSRA CTEIERLSTE
310 320 330 340 350
REKDGVFTGA YVTNRVNGHK VPVWIGDYVL QSYGTGAVMG VPAHDERDFV
360 370 380 390 400
FAQKYDLPVI TVIAPPDYDG QPLEAAYINE GVMQNSGPFN GLPNTEGKEK
410 420 430 440 450
VCDYLAEHGW GKKTVNYKLR DWLISRQRYW GAPIPMIYCE KCGIVPVPEK
460 470 480 490 500
DLPVLLPEDV EFRSGGESPL KYNEGFVNTT CPVCGGKAKR ETDTMDTFMC
510 520 530 540 550
SSWYFLRYTS PGYDKGPFDP EKLRYWMPVD LYTGGAEHAV MHLFYSRFFT
560 570 580 590 600
KALRDMGIID FGEPFKKLFN QGIIVSNHQK MSKSKGNVVT PDNLVAEVGT
610 620 630 640 650
DAVRAYLMFV GPWDQGGEWN DSGLSGMSRW LNRVWNLFTE EYTPQTASAE
660 670 680 690 700
AERELKRTLH QTIKKITMDI ERLRFNTVVA ALMELSNSLA KFKEAAAVSA
710 720 730 740 750
ESWQNSLKTF ALMLAPVAPH IAEELWANLD MEYSIHNQSW PKWDEELAKD
760 770 780 790 800
EVITLIIQVN GKLRERLEMP AGISEDEAKE TALNSTRVKP HLQGKTPASV
810
IYVPGKLVNI VVK
Length:813
Mass (Da):92,868
Last modified:September 27, 2005 - v1
Checksum:i493634ACB295ADB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA Translation: AAW40547.1
RefSeqiWP_010935997.1, NC_002936.3

Genome annotation databases

EnsemblBacteriaiAAW40547; AAW40547; DET0194
GeneIDi3230512
KEGGidet:DET0194
PATRICifig|243164.10.peg.179

Similar proteinsi

Entry informationi

Entry nameiSYL_DEHM1
AccessioniPrimary (citable) accession number: Q3ZA07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 27, 2005
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health