ID   AROE_DEHE1              Reviewed;         286 AA.
AC   Q3Z990;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=DET0465;
OS   Dehalococcoides ethenogenes (strain 195).
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M.,
RA   Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M.,
RA   Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M.,
RA   Sullivan S.A., Madupu R., Nelson K.E., Kang K.H., Impraim M., Tran K.,
RA   Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H.,
RA   Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000027; AAW40206.1; -; Genomic_DNA.
DR   RefSeq; YP_181209.1; -.
DR   GeneID; 3230170; -.
DR   GenomeReviews; CP000027_GR; DET0465.
DR   KEGG; det:DET0465; -.
DR   NMPDR; fig|243164.3.peg.727; -.
DR   TIGR; DET0465; -.
DR   HOGENOM; Q3Z990; -.
DR   OMA; Q3Z990; ATAIQVQ.
DR   BioCyc; DETH243164:DET_0465-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    286       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000058660.
FT   NP_BIND     130    134       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
SQ   SEQUENCE   286 AA;  31194 MW;  6ECE253437E7345F CRC64;
     MKTIPDALFG LIGFPVSHSV SPAMQNAAFK HCKLDYLYLT IAAKPEELQN VIASMGPLNI
     RGLNVTIPHK IEVIKYIDSL DPAAEKIGAV NTIVNENGRL KGYNTDFGGF VRLLEHNRIA
     PAKQRFTLLG AGGSAHAIAL AVCNLGGHLT VLARQEEKAK DLAGKMCLRL SGKTQGLELN
     DTNLEEALAD TDVIVNCTPV GMGNLAGQSL VPPRLLRPDL TVIDAIYNPC KTRLLEDAEK
     RGARIINGLE MLVWQGAMSF EIWTNQKAPF RLMMKEAELA LDENKK
//