ID   AROD_DEHE1              Reviewed;         222 AA.
AC   Q3Z989;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=3-dehydroquinate dehydratase;
DE            Short=3-dehydroquinase;
DE            EC=4.2.1.10;
DE   AltName: Full=Type I DHQase;
GN   Name=aroD; OrderedLocusNames=DET0466;
OS   Dehalococcoides ethenogenes (strain 195).
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M.,
RA   Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M.,
RA   Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M.,
RA   Sullivan S.A., Madupu R., Nelson K.E., Kang K.H., Impraim M., Tran K.,
RA   Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H.,
RA   Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 3/7.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the type-I 3-dehydroquinase family.
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DR   EMBL; CP000027; AAW40205.1; -; Genomic_DNA.
DR   RefSeq; YP_181210.1; -.
DR   GeneID; 3230169; -.
DR   GenomeReviews; CP000027_GR; DET0466.
DR   KEGG; det:DET0466; -.
DR   NMPDR; fig|243164.3.peg.728; -.
DR   TIGR; DET0466; -.
DR   HOGENOM; Q3Z989; -.
DR   OMA; Q3Z989; LAPFTYA.
DR   BioCyc; DETH243164:DET_0466-MON; -.
DR   GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   HAMAP; MF_00214; -; 1.
DR   InterPro; IPR018508; 3-dehydroquinate_DH_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001381; DHquinase_I.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF01487; DHquinase_I; 1.
DR   ProDom; PD005337; DHquinase_I; 1.
DR   TIGRFAMs; TIGR01093; aroD; 1.
DR   PROSITE; PS01028; DEHYDROQUINASE_I; FALSE_NEG.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Schiff base.
FT   CHAIN         1    222       3-dehydroquinate dehydratase.
FT                                /FTId=PRO_0000325522.
FT   ACT_SITE    112    112       Proton acceptor (By similarity).
FT   ACT_SITE    139    139       Schiff-base intermediate with substrate
FT                                (By similarity).
SQ   SEQUENCE   222 AA;  24366 MW;  B174BD2BA2BC2266 CRC64;
     MKNPPVCCVI TRLPEAESLK KSEGAAFYEL RLDLLGESWR EAAAMLDKPF MATCRRSAEG
     GSFSGSEEER IGLLEKAAAA GAFMLDIEYS TPHLGEVLKR LRTQSKCLVS HHNFADTPSA
     GDLKTLVKDM LNYPADIYKV ITTATSINDN IKLLNLIKEI PDKKIVAFAM GNLGILSRIL
     CPLAGSPFTY ASLNDSNQSA SGQMTLAQMI EIYRSVNYEN HT
//