Q3Z988 (AROB_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate synthase
EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	DET0467

Organism

Dehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]

Taxonomic identifier

243164 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000231084

Sequences

	Sequence		Length	Mass (Da)
	Q3Z988 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: C6688B90289C6D31	FASTA	359	39,030
	10 20 30 40 50 60 MKSIGLNLSG REYKILIGSD LLAETADLLK QAIPCDRVVV ITNIDINRLY GKKLKKHLES 70 80 90 100 110 120 KGIGSLFLEL PEGEIHKSLD MASHIYPQLI NHFAERNTPI LALGGGVIGD LSGFVAATYQ 130 140 150 160 170 180 RGVPLVHLPT SLLSQVDSSI GGKVAVNHGG IKNIVGSFYQ PRLVISDISC LKTLPEKEFA 190 200 210 220 230 240 CGMAEIIKSA AIGSSELFKQ LETNTPAIKD RSPEIMEDII SQTAAIKAGI VCQDETDRGI 250 260 270 280 290 300 RNILNFGHTL GHALESTSSF SQSHGAAVAI GMCFASRLSV KLGLCENETV LRLEKLIADF 310 320 330 340 350 GLPTRPQDID PEKIIDAMHH DKKVSDGRIR FILLKRPGEP LIAENILRAD VISILEEMK

References

[1]

"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes." Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H. , Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F. Science 307:105-108(2005) [PubMed: 15637277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000027 Genomic DNA. Translation: AAW40204.1.
RefSeq	YP_181211.1. NC_002936.3.
3D structure databases
ProteinModelPortal	Q3Z988.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3Z988.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3230168.
GenomeReviews	Gene locus DET0467 in contig CP000027_GR.
KEGG	det:DET0467.
NMPDR	fig|243164.3.peg.729.
PATRIC	21608003. VBIDehEth89364_0445.
TIGR	DET0467.
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	VMALEMS.
PhylomeDB	Q3Z988.
ProtClustDB	PRK00002.
Enzyme and pathway databases
BioCyc	DETH243164:DET_0467-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016037. DHQ_synth_AroB. [Graphical view]
KO	K01735.
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. AroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_DEHE1

Accession

Primary (citable) accession number: Q3Z988

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program