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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:DET0603
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002240491 – 1272DNA-directed RNA polymerase subunit betaAdd BLAST1272

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi243164.DET0603.

Structurei

3D structure databases

ProteinModelPortaliQ3Z8V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QIH. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218612.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 3 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3Z8V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSMLPKADA ATGITRKSYA QLPEVVNVPN LIEMQLQSFV WFQEEGLREL
60 70 80 90 100
IEEISPIKDF VGNRLELEFI GYEFREPRLS EYECTQRDQT YSVPLYVKAR
110 120 130 140 150
LIVKTTGEIK EPFDLFFGDI PLMTALGTFI TSGTERVVVS QLLRSPGVYF
160 170 180 190 200
TISDDPATGR PLCHTNLIPS RGAWLEFETS NRDVISVKID GRRKIPVSTL
210 220 230 240 250
LRAIGYSDDL DILNLFEVID NDPERHYIQS SIDRDPLIKD EISALIDIYS
260 270 280 290 300
RLRPGDPPNA DNARKLINEM FFDPQHYDLG KVGRYKVNRR LELPDREVGD
310 320 330 340 350
NRALTREDIV AIIKRIIMVN NGQDTPDDID HLGNRRIRTV GELVQNQFRI
360 370 380 390 400
GLVRLERVAR ERMSIVNLEV VTPSALVNIR PVVSAVKEFF GGSQLSQFMD
410 420 430 440 450
QTNPLAEITN KRRLSAMGPG GLSRERAGFD VRDVHYSHYG RICPIETPEG
460 470 480 490 500
PNIGLIGSLA TYSRINRYGF VETPYRKVYS KLKNNDKKLV GLKLAAAVSD
510 520 530 540 550
KDKVLASAGS VVSEENFKLI SKLPECDIQV MPFVSAEVKY MPADEEDRYI
560 570 580 590 600
IAQANTRLDE NGYFLDERIE ARLAERYVIE PPEKIDYMDV SPKQIFSVAA
610 620 630 640 650
SLIPFLEHDD ANRALMGANM QRQAVPLLRA EAPMVATGME REAARYSGQV
660 670 680 690 700
IFAKRAGVAA SVTSEKIIIR TAEGQDDEYL LKKFVRTNQG TCINQHAVIN
710 720 730 740 750
KGQKIEAGQV LADSSATENG ELALGQNCVV AFMSWQGFNY EDAIILSERL
760 770 780 790 800
VREDAFTSIH ITKHELEAHD TKLGGEEITR DIPNVGEESL RELDEDGIIR
810 820 830 840 850
IGAEVGPDDI LVGKITPKGE TELSAEEKLL RAIFGEKARE VKDTSLRMPH
860 870 880 890 900
GEWGKVINVR VFSRENGDDL PARVNKWVQV WVAQKRKVSV GDKLAGRHGN
910 920 930 940 950
KGVISIIAPV EDMPYLPDGT PVDVVLNPIG VPSRMNLGQI LETHLGWAGH
960 970 980 990 1000
LLGFRVATPV FDGADDTAIE DALARSWLSA KAGATDMSPE NKRPSTDTAK
1010 1020 1030 1040 1050
AVEWIKQQGF DGKKVFDERH PGLAKEVSLK LWLKDMGVDA SSLSGAELEK
1060 1070 1080 1090 1100
KAYEVSSQSR LPSPIVGKSV LRDGRTGETF DQPVTVGNMY ILKLIHLVED
1110 1120 1130 1140 1150
KVHARATGPY SLISQQPLGG KAQFGGQRFG EMEVWAMYAY GTAHNLQEML
1160 1170 1180 1190 1200
TIKSDDIAGR AKAYESIVKG EDVIQPGVPE SFKVLVKELQ SLGLAVEVIN
1210 1220 1230 1240 1250
EEVKIAPSEK VAALTEANLP GSEDVSAEIL PETLYAGAED IEDSMMSVID
1260 1270
TDDQDLAMSS NDEEVSENDE RS
Length:1,272
Mass (Da):141,366
Last modified:September 27, 2005 - v1
Checksum:iAFBB698CF021FAC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW40097.1.
RefSeqiWP_010936378.1. NC_002936.3.

Genome annotation databases

EnsemblBacteriaiAAW40097; AAW40097; DET0603.
GeneIDi3230060.
KEGGidet:DET0603.
PATRICi21608277. VBIDehEth89364_0581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW40097.1.
RefSeqiWP_010936378.1. NC_002936.3.

3D structure databases

ProteinModelPortaliQ3Z8V4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243164.DET0603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW40097; AAW40097; DET0603.
GeneIDi3230060.
KEGGidet:DET0603.
PATRICi21608277. VBIDehEth89364_0581.

Phylogenomic databases

eggNOGiENOG4107QIH. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218612.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 3 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB_DEHM1
AccessioniPrimary (citable) accession number: Q3Z8V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: September 27, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.