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Q3Z8K3

- FTHS_DEHM1

UniProt

Q3Z8K3 - FTHS_DEHM1

Protein

Formate--tetrahydrofolate ligase

Gene

fhs1

more
Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi84 – 918ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDETH243164:GJNF-672-MONOMER.
    DETH243164:GJNF-706-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhs1UniRule annotation
    Synonyms:fhs-1
    Ordered Locus Names:DET0671
    AND
    Name:fhs2UniRule annotation
    Synonyms:fhs-2
    Ordered Locus Names:DET0705
    OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
    Taxonomic identifieri243164 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
    ProteomesiUP000008289: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 597597Formate--tetrahydrofolate ligasePRO_0000199344Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243164.DET0705.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3Z8K3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3Z8K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTINNRKSHL KDLDPGLMKD WEIAEKAEEF LKPSKMLAEE LGLTEDEIIP    50
    HGKYVAKVDF AGVLTRLKDR PNGKYIDVTA ITPTPLGEGK STTTMGLVQG 100
    LGNLGKKVTG AIRQPSSGPT FNIKGSAAGG GRSQCLPLSP FTLGLTGDID 150
    AVTNSHNLAM VALQARIQHE ANNTDEFLSS RSLKRLDIDP ARVELKWAID 200
    FCAQSLREII MGIGGKTDGY QMHSGFGISV SSEVMAILSV FTGLADLRER 250
    MSKIIVAYRQ NGEPVTTADL EVDGAMTALL LRAVNPNLLQ TIEGQPVFVH 300
    AGPFANIAIG QSSIVADRLA LKLADYHVTE SGFGADIGFE KFWNIKCRLS 350
    GLKPDCAVIV ATVRALKMHG GGPKVTPGAP LDPAYTTPNA ALVEKGCQNM 400
    LAHIQTVKTA GINPVVCINH FAADTAQEID IIRRTAEQAG ARVAVSYHWA 450
    NGGEGAAELA EAVIDACNEP NDFHFLYPED MPLRERIYTI ARKVYGADGV 500
    SYTQTALEKL ARLENTGNTQ FMPSCMVKTH LSLSHDPALK GRPGGFTLPI 550
    RDILTYMGAG LVVPVAGDIK LMPGTSSDPN FRRIDIDTHT GKVKGLF 597
    Length:597
    Mass (Da):64,225
    Last modified:September 27, 2005 - v1
    Checksum:i87DB9B994C1B9E89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000027 Genomic DNA. Translation: AAW39992.1.
    CP000027 Genomic DNA. Translation: AAW40064.1.
    RefSeqiWP_010936446.1. NC_002936.3.
    YP_181413.1. NC_002936.3.
    YP_181446.1. NC_002936.3.

    Genome annotation databases

    EnsemblBacteriaiAAW39992; AAW39992; DET0705.
    AAW40064; AAW40064; DET0671.
    GeneIDi3229954.
    3230027.
    KEGGidet:DET0671.
    det:DET0705.
    PATRICi21608405. VBIDehEth89364_0645.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000027 Genomic DNA. Translation: AAW39992.1 .
    CP000027 Genomic DNA. Translation: AAW40064.1 .
    RefSeqi WP_010936446.1. NC_002936.3.
    YP_181413.1. NC_002936.3.
    YP_181446.1. NC_002936.3.

    3D structure databases

    ProteinModelPortali Q3Z8K3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243164.DET0705.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW39992 ; AAW39992 ; DET0705 .
    AAW40064 ; AAW40064 ; DET0671 .
    GeneIDi 3229954.
    3230027.
    KEGGi det:DET0671.
    det:DET0705.
    PATRICi 21608405. VBIDehEth89364_0645.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DETH243164:GJNF-672-MONOMER.
    DETH243164:GJNF-706-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-2266 / KCTC 15142 / 195.

    Entry informationi

    Entry nameiFTHS_DEHM1
    AccessioniPrimary (citable) accession number: Q3Z8K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3