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Q3Z8K3 (FTHS_DEHM1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs1
Synonyms:fhs-1
Ordered Locus Names:DET0671
AND
Name:fhs2
Synonyms:fhs-2
Ordered Locus Names:DET0705
OrganismDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195)) [Complete proteome] [HAMAP]
Taxonomic identifier243164 [NCBI]
Taxonomic lineageBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 597597Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199344

Regions

Nucleotide binding84 – 918ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3Z8K3 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 87DB9B994C1B9E89

FASTA59764,225
        10         20         30         40         50         60 
MTINNRKSHL KDLDPGLMKD WEIAEKAEEF LKPSKMLAEE LGLTEDEIIP HGKYVAKVDF 

        70         80         90        100        110        120 
AGVLTRLKDR PNGKYIDVTA ITPTPLGEGK STTTMGLVQG LGNLGKKVTG AIRQPSSGPT 

       130        140        150        160        170        180 
FNIKGSAAGG GRSQCLPLSP FTLGLTGDID AVTNSHNLAM VALQARIQHE ANNTDEFLSS 

       190        200        210        220        230        240 
RSLKRLDIDP ARVELKWAID FCAQSLREII MGIGGKTDGY QMHSGFGISV SSEVMAILSV 

       250        260        270        280        290        300 
FTGLADLRER MSKIIVAYRQ NGEPVTTADL EVDGAMTALL LRAVNPNLLQ TIEGQPVFVH 

       310        320        330        340        350        360 
AGPFANIAIG QSSIVADRLA LKLADYHVTE SGFGADIGFE KFWNIKCRLS GLKPDCAVIV 

       370        380        390        400        410        420 
ATVRALKMHG GGPKVTPGAP LDPAYTTPNA ALVEKGCQNM LAHIQTVKTA GINPVVCINH 

       430        440        450        460        470        480 
FAADTAQEID IIRRTAEQAG ARVAVSYHWA NGGEGAAELA EAVIDACNEP NDFHFLYPED 

       490        500        510        520        530        540 
MPLRERIYTI ARKVYGADGV SYTQTALEKL ARLENTGNTQ FMPSCMVKTH LSLSHDPALK 

       550        560        570        580        590 
GRPGGFTLPI RDILTYMGAG LVVPVAGDIK LMPGTSSDPN FRRIDIDTHT GKVKGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000027 Genomic DNA. Translation: AAW39992.1.
CP000027 Genomic DNA. Translation: AAW40064.1.
RefSeqYP_181413.1. NC_002936.3.
YP_181446.1. NC_002936.3.

3D structure databases

ProteinModelPortalQ3Z8K3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243164.DET0705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW39992; AAW39992; DET0705.
AAW40064; AAW40064; DET0671.
GeneID3229954.
3230027.
KEGGdet:DET0671.
det:DET0705.
PATRIC21608405. VBIDehEth89364_0645.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycDETH243164:GJNF-672-MONOMER.
DETH243164:GJNF-706-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_DEHM1
AccessionPrimary (citable) accession number: Q3Z8K3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways