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Q3Z8K3

- FTHS_DEHM1

UniProt

Q3Z8K3 - FTHS_DEHM1

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs1

more
Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 918ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDETH243164:GJNF-672-MONOMER.
DETH243164:GJNF-706-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Synonyms:fhs-1
Ordered Locus Names:DET0671
AND
Name:fhs2UniRule annotation
Synonyms:fhs-2
Ordered Locus Names:DET0705
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000008289: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Formate--tetrahydrofolate ligasePRO_0000199344Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243164.DET0705.

Structurei

3D structure databases

ProteinModelPortaliQ3Z8K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3Z8K3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTINNRKSHL KDLDPGLMKD WEIAEKAEEF LKPSKMLAEE LGLTEDEIIP
60 70 80 90 100
HGKYVAKVDF AGVLTRLKDR PNGKYIDVTA ITPTPLGEGK STTTMGLVQG
110 120 130 140 150
LGNLGKKVTG AIRQPSSGPT FNIKGSAAGG GRSQCLPLSP FTLGLTGDID
160 170 180 190 200
AVTNSHNLAM VALQARIQHE ANNTDEFLSS RSLKRLDIDP ARVELKWAID
210 220 230 240 250
FCAQSLREII MGIGGKTDGY QMHSGFGISV SSEVMAILSV FTGLADLRER
260 270 280 290 300
MSKIIVAYRQ NGEPVTTADL EVDGAMTALL LRAVNPNLLQ TIEGQPVFVH
310 320 330 340 350
AGPFANIAIG QSSIVADRLA LKLADYHVTE SGFGADIGFE KFWNIKCRLS
360 370 380 390 400
GLKPDCAVIV ATVRALKMHG GGPKVTPGAP LDPAYTTPNA ALVEKGCQNM
410 420 430 440 450
LAHIQTVKTA GINPVVCINH FAADTAQEID IIRRTAEQAG ARVAVSYHWA
460 470 480 490 500
NGGEGAAELA EAVIDACNEP NDFHFLYPED MPLRERIYTI ARKVYGADGV
510 520 530 540 550
SYTQTALEKL ARLENTGNTQ FMPSCMVKTH LSLSHDPALK GRPGGFTLPI
560 570 580 590
RDILTYMGAG LVVPVAGDIK LMPGTSSDPN FRRIDIDTHT GKVKGLF
Length:597
Mass (Da):64,225
Last modified:September 27, 2005 - v1
Checksum:i87DB9B994C1B9E89
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000027 Genomic DNA. Translation: AAW39992.1.
CP000027 Genomic DNA. Translation: AAW40064.1.
RefSeqiYP_181413.1. NC_002936.3.
YP_181446.1. NC_002936.3.

Genome annotation databases

EnsemblBacteriaiAAW39992; AAW39992; DET0705.
AAW40064; AAW40064; DET0671.
GeneIDi3229954.
3230027.
KEGGidet:DET0671.
det:DET0705.
PATRICi21608405. VBIDehEth89364_0645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000027 Genomic DNA. Translation: AAW39992.1 .
CP000027 Genomic DNA. Translation: AAW40064.1 .
RefSeqi YP_181413.1. NC_002936.3.
YP_181446.1. NC_002936.3.

3D structure databases

ProteinModelPortali Q3Z8K3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243164.DET0705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW39992 ; AAW39992 ; DET0705 .
AAW40064 ; AAW40064 ; DET0671 .
GeneIDi 3229954.
3230027.
KEGGi det:DET0671.
det:DET0705.
PATRICi 21608405. VBIDehEth89364_0645.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DETH243164:GJNF-672-MONOMER.
DETH243164:GJNF-706-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-2266 / KCTC 15142 / 195.

Entry informationi

Entry nameiFTHS_DEHM1
AccessioniPrimary (citable) accession number: Q3Z8K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3