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Q3Z8G9 (DXS_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:DET0745
OrganismDehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]
Taxonomic identifier243164 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length647 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6476471-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
PRO_0000256408

Sequences

Sequence LengthMass (Da)Tools
Q3Z8G9 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 71763B479338118E

FASTA64769,939
        10         20         30         40         50         60 
MHTGLEISIP HNLQMSKLLD TINSPSDLKK LTLDELRELA VQIREELVNR VTLNGGHLAS 

        70         80         90        100        110        120 
SLGVVELTIA LHRVFESPKD KIIWDVGHQS YAHKLLTGRR EQFATLRQHG GLSGFTCRDE 

       130        140        150        160        170        180 
SPHDPFGAGH ASTSISAGLG MAVARDLAKE DYSVISVIGD GAISGGMSFE AINNAGHLHT 

       190        200        210        220        230        240 
KFIVILNDNG MAISPSTGAL SKFLNNVRFD PRFEFAKRGA KQTITNMPFG KSVWAFTKSI 

       250        260        270        280        290        300 
KRKFEKSMLP GSLWEELGFI YLGPVDGHNI RELEAALKCA KDFESQPVLI HMITKKGKGY 

       310        320        330        340        350        360 
DDAEADAVKY HGIAPKSGGL KSGHGLSYSQ VFGQTLHKIM SDNPKVVAIT AAMTDGCGLS 

       370        380        390        400        410        420 
EVAADFPDRV FDVGICEQHA VTFAAGMATQ GYIPVVVIYS TFLQRSFDQI IHDVCLQKLP 

       430        440        450        460        470        480 
VVFAIDRGGI VGDDGKTHQG IFDLSFMSLI PDMIVTAPSD ENDLQHLLYT AVNSGKPFAL 

       490        500        510        520        530        540 
RYPRGFGEGV ETEGTLRNIP IGENEVLASG SEIAIFATGK SVAFAKEAME ILAESGIKPT 

       550        560        570        580        590        600 
LVNNRYISPL DTELILKIAG NHKYLITVEE NVLSGGLGSR INTILAEAGL VNAVKIANIA 

       610        620        630        640 
VPDKFVEHGN QSLLRAKYGL DGKGIAQKVL SLMANTGEAK HQQILCP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000027 Genomic DNA. Translation: AAW39984.1.
RefSeqYP_181480.1. NC_002936.3.

3D structure databases

ProteinModelPortalQ3Z8G9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3Z8G9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3229946.
GenomeReviewsGene locus DET0745 in contig CP000027_GR.
KEGGdet:DET0745.
NMPDRfig|243164.3.peg.846.
PATRIC21608553. VBIDehEth89364_0713.
TIGRDET0745.

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMAQYDISYM.
PhylomeDBQ3Z8G9.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycDETH243164:DET_0745-MONOMER.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR001017. DH_E1.
IPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_DEHE1
AccessionPrimary (citable) accession number: Q3Z8G9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 27, 2005
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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