Q3Z8C6 (ADEC_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	DET0791

Organism

Dehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]

Taxonomic identifier

243164 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	571 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity. HAMAP MF_01518
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 571	571	Adenine deaminase HAMAP MF_01518		PRO_0000142414

Sequences

	Sequence		Length	Mass (Da)
	Q3Z8C6 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 82F658B11AF088A8	FASTA	571	61,063
	10 20 30 40 50 60 MQTNLSQLIK VARGEAKADL VLLNARVVNV FNAEIEPANV AVFGGQIAGV GDYTLGNRVL 70 80 90 100 110 120 DLKGAYLLPG LINGHTHVES SMLDISQYAR AVIAHGTSAL ITDLHEISNV CGKEGIDYVL 130 140 150 160 170 180 SASADLPLNI FLQVPSCVPA THLETAGAEI NSNDVTELLR LPNVTGLGEM MNFPGVLFGI 190 200 210 220 230 240 PSVLDKIEAA SGKVLDGHAP GLSGKDLNAY ISAGIHSDHE CIQLDEAKEK LARGMYIMIR 250 260 270 280 290 300 EGSSEKNLTE LLPLVTDKTY KRCIFVVDDR SCADLQRDGD IDAVVRKAIK LGLDPVRAIQ 310 320 330 340 350 360 LASINTAEYF RLNGHGAIAP GYLANMIVCQ DLNQLDIDMV FHKGELVAEK GQVLFKPQSH 370 380 390 400 410 420 VPKSLLSSMH IKPFDIKDLA IKGSSTQMPV IEVIPGQIVT RRLNLKIPAE NGVLTPDIEQ 430 440 450 460 470 480 DLLKIVVLER HCQSGNIGRG LIKGFGLKKG AIASSVAHDS HNVIAVGTND ADIYTAVKEL 490 500 510 520 530 540 ERINGGIALV VDGKISASVP LPVAGLLSTQ PLEKVVDALE EINKQAAGLG CKLSAPFATL 550 560 570 SFMALPVIPE LRLTDLGLVD VNAFKLIPQE T

References

[1]

"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes." Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H. , Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F. Science 307:105-108(2005) [PubMed: 15637277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000027 Genomic DNA. Translation: AAW39904.1.
RefSeq	YP_181523.1. NC_002936.3.
3D structure databases
ProteinModelPortal	Q3Z8C6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3Z8C6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3229866.
GenomeReviews	Gene locus DET0791 in contig CP000027_GR.
KEGG	det:DET0791.
NMPDR	fig|243164.3.peg.983.
PATRIC	21608643. VBIDehEth89364_0755.
TIGR	DET0791.
Phylogenomic databases
eggNOG	COG1001.
HOGENOM	HBG725357.
OMA	VGLGEMM.
PhylomeDB	Q3Z8C6.
ProtClustDB	CLSK837263.
Enzyme and pathway databases
BioCyc	DETH243164:DET_0791-MONOMER.
Family and domain databases
HAMAP	MF_01518. Adenine_deamin. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01486.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01178. Ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_DEHE1

Accession

Primary (citable) accession number: Q3Z8C6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program