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Q3Z8B3 (PANC_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantothenate synthetase

Short name=PS
EC=6.3.2.1
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene names
Name:panC
Ordered Locus Names:DET0804
OrganismDehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]
Taxonomic identifier243164 [NCBI]
Taxonomic lineageBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Sequence similarities

Belongs to the pantothenate synthetase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantoate-beta-alanine ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Pantothenate synthetase HAMAP-Rule MF_00158
PRO_0000305435

Regions

Nucleotide binding18 – 258ATP By similarity
Nucleotide binding135 – 1384ATP By similarity
Nucleotide binding172 – 1754ATP By similarity

Sites

Active site251Proton donor By similarity
Binding site491Beta-alanine By similarity
Binding site491Pantoate By similarity
Binding site1411Pantoate By similarity
Binding site1641ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3Z8B3 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: BD93EE49D0F1C7AB

FASTA26830,142
        10         20         30         40         50         60 
MQKLHREICG PVGLVPTMGY LHEGHLSLIR ASKKQDLNTV ASIFVNPTQF GPHEDFKKYP 

        70         80         90        100        110        120 
RDEKRDMAML ENAGVDYVFA PSVEEMYPPG FDSWVEPGVL QERLEGAVRP GHFRGVCTVV 

       130        140        150        160        170        180 
AKLFTIICPA KAYFGQKDYQ QYLIIKKMAS DLNLDVSVEM LPIVRESDGL ALSSRNTYLS 

       190        200        210        220        230        240 
ASERKAALVL YRSLLTAKSL FAAKEYNPEI IRRKMTEEIQ RESLAEIDYV SLSDQDTLGE 

       250        260 
ADKVSIKTIA LVAARFGKTR LIDNMFLA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000027 Genomic DNA. Translation: AAW39875.1.
RefSeqYP_181536.1. NC_002936.3.

3D structure databases

ProteinModelPortalQ3Z8B3.
SMRQ3Z8B3. Positions 8-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243164.DET0804.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW39875; AAW39875; DET0804.
GeneID3229837.
KEGGdet:DET0804.
PATRIC21608667. VBIDehEth89364_0767.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0414.
HOGENOMHOG000175516.
KOK01918.
OMAIRELRAW.
OrthoDBEOG6Z6FZ4.
ProtClustDBPRK00380.

Enzyme and pathway databases

BioCycDETH243164:GJNF-805-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANC_DEHE1
AccessionPrimary (citable) accession number: Q3Z8B3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 27, 2005
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways