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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (DET0845), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. no protein annotated in this organism
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazoleglycerol phosphate synthase, cyclase subunit, putative (DET0960)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136NADUniRule annotation1
Binding sitei198NADUniRule annotation1
Binding sitei221NADUniRule annotation1
Binding sitei244SubstrateUniRule annotation1
Metal bindingi266ZincUniRule annotation1
Binding sitei266SubstrateUniRule annotation1
Metal bindingi269ZincUniRule annotation1
Binding sitei269SubstrateUniRule annotation1
Active sitei334Proton acceptorUniRule annotation1
Active sitei335Proton acceptorUniRule annotation1
Binding sitei335SubstrateUniRule annotation1
Metal bindingi368ZincUniRule annotation1
Binding sitei368SubstrateUniRule annotation1
Binding sitei422SubstrateUniRule annotation1
Metal bindingi427ZincUniRule annotation1
Binding sitei427SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciDMCC243164:G1G45-817-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:DET0844
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001357641 – 436Histidinol dehydrogenaseAdd BLAST436

Interactioni

Protein-protein interaction databases

STRINGi243164.DET0844

Structurei

3D structure databases

ProteinModelPortaliQ3Z878
SMRiQ3Z878
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3Z878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIRGFAPA EKRLSRRDKA GFFLDETQRA ELAKRLGVDP EKAVNGIIDD
60 70 80 90 100
IRKQGDKAVL EYTLKFDRAA ISKLEVSPAE IKQAAGEIPA ELFEALKLAA
110 120 130 140 150
TQVRAYHHFQ KEAVWKAAEI MQGKQLIRPL ERVGLYVPGG KAFYPSTVLM
160 170 180 190 200
TAIPAKEAGV DEIILVTPPG ADGKIPAPTL AAAYIAGVDK VFACGGAQAV
210 220 230 240 250
AALAFGTKSI PKVDKICGPG NIFVTLAKKA VFGVVDIDGL QGPSEVLILA
260 270 280 290 300
DQYANAEYCA SDILAQAEHD VLASPIMVTT SAELAKRVND IVETKAGSCA
310 320 330 340 350
RKDIIRQSLR DNGLIAVVDN MDEAIKLANM YATEHLCLLV KDSEQYLSRI
360 370 380 390 400
NHAGCIFYGE KASVVMGDYV AGPSHALPTS GTARFSSPLN ILDFVKYIDI
410 420 430
VNVSKEEVTK LGKAAVTIAR AEGLECHAEA ALKRME
Length:436
Mass (Da):46,836
Last modified:September 27, 2005 - v1
Checksum:iB5BDCD65764EA53F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA Translation: AAW39898.1
RefSeqiWP_010936572.1, NC_002936.3

Genome annotation databases

EnsemblBacteriaiAAW39898; AAW39898; DET0844
GeneIDi3229860
KEGGidet:DET0844
PATRICifig|243164.10.peg.802

Similar proteinsi

Entry informationi

Entry nameiHISX_DEHM1
AccessioniPrimary (citable) accession number: Q3Z878
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 27, 2005
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health