Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3Z878

- HISX_DEHM1

UniProt

Q3Z878 - HISX_DEHM1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NADUniRule annotation
Binding sitei198 – 1981NADUniRule annotation
Binding sitei221 – 2211NADUniRule annotation
Binding sitei244 – 2441SubstrateUniRule annotation
Metal bindingi266 – 2661ZincUniRule annotation
Binding sitei266 – 2661SubstrateUniRule annotation
Metal bindingi269 – 2691ZincUniRule annotation
Binding sitei269 – 2691SubstrateUniRule annotation
Active sitei334 – 3341Proton acceptorUniRule annotation
Active sitei335 – 3351Proton acceptorUniRule annotation
Binding sitei335 – 3351SubstrateUniRule annotation
Metal bindingi368 – 3681ZincUniRule annotation
Binding sitei368 – 3681SubstrateUniRule annotation
Binding sitei422 – 4221SubstrateUniRule annotation
Metal bindingi427 – 4271ZincUniRule annotation
Binding sitei427 – 4271SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciDETH243164:GJNF-845-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:DET0844
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000008289: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Histidinol dehydrogenasePRO_0000135764Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243164.DET0844.

Structurei

3D structure databases

ProteinModelPortaliQ3Z878.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3Z878-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIIRGFAPA EKRLSRRDKA GFFLDETQRA ELAKRLGVDP EKAVNGIIDD
60 70 80 90 100
IRKQGDKAVL EYTLKFDRAA ISKLEVSPAE IKQAAGEIPA ELFEALKLAA
110 120 130 140 150
TQVRAYHHFQ KEAVWKAAEI MQGKQLIRPL ERVGLYVPGG KAFYPSTVLM
160 170 180 190 200
TAIPAKEAGV DEIILVTPPG ADGKIPAPTL AAAYIAGVDK VFACGGAQAV
210 220 230 240 250
AALAFGTKSI PKVDKICGPG NIFVTLAKKA VFGVVDIDGL QGPSEVLILA
260 270 280 290 300
DQYANAEYCA SDILAQAEHD VLASPIMVTT SAELAKRVND IVETKAGSCA
310 320 330 340 350
RKDIIRQSLR DNGLIAVVDN MDEAIKLANM YATEHLCLLV KDSEQYLSRI
360 370 380 390 400
NHAGCIFYGE KASVVMGDYV AGPSHALPTS GTARFSSPLN ILDFVKYIDI
410 420 430
VNVSKEEVTK LGKAAVTIAR AEGLECHAEA ALKRME
Length:436
Mass (Da):46,836
Last modified:September 27, 2005 - v1
Checksum:iB5BDCD65764EA53F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW39898.1.
RefSeqiWP_010936572.1. NC_002936.3.
YP_181571.1. NC_002936.3.

Genome annotation databases

EnsemblBacteriaiAAW39898; AAW39898; DET0844.
GeneIDi3229860.
KEGGidet:DET0844.
PATRICi21608747. VBIDehEth89364_0802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW39898.1 .
RefSeqi WP_010936572.1. NC_002936.3.
YP_181571.1. NC_002936.3.

3D structure databases

ProteinModelPortali Q3Z878.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243164.DET0844.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW39898 ; AAW39898 ; DET0844 .
GeneIDi 3229860.
KEGGi det:DET0844.
PATRICi 21608747. VBIDehEth89364_0802.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci DETH243164:GJNF-845-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-2266 / KCTC 15142 / 195.

Entry informationi

Entry nameiHISX_DEHM1
AccessioniPrimary (citable) accession number: Q3Z878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 27, 2005
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3