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Q3Z878

- HISX_DEHM1

UniProt

Q3Z878 - HISX_DEHM1

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361NADUniRule annotation
    Binding sitei198 – 1981NADUniRule annotation
    Binding sitei221 – 2211NADUniRule annotation
    Binding sitei244 – 2441SubstrateUniRule annotation
    Metal bindingi266 – 2661ZincUniRule annotation
    Binding sitei266 – 2661SubstrateUniRule annotation
    Metal bindingi269 – 2691ZincUniRule annotation
    Binding sitei269 – 2691SubstrateUniRule annotation
    Active sitei334 – 3341Proton acceptorUniRule annotation
    Active sitei335 – 3351Proton acceptorUniRule annotation
    Binding sitei335 – 3351SubstrateUniRule annotation
    Metal bindingi368 – 3681ZincUniRule annotation
    Binding sitei368 – 3681SubstrateUniRule annotation
    Binding sitei422 – 4221SubstrateUniRule annotation
    Metal bindingi427 – 4271ZincUniRule annotation
    Binding sitei427 – 4271SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciDETH243164:GJNF-845-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:DET0844
    OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
    Taxonomic identifieri243164 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
    ProteomesiUP000008289: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Histidinol dehydrogenasePRO_0000135764Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243164.DET0844.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3Z878.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3Z878-1 [UniParc]FASTAAdd to Basket

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    MEIIRGFAPA EKRLSRRDKA GFFLDETQRA ELAKRLGVDP EKAVNGIIDD    50
    IRKQGDKAVL EYTLKFDRAA ISKLEVSPAE IKQAAGEIPA ELFEALKLAA 100
    TQVRAYHHFQ KEAVWKAAEI MQGKQLIRPL ERVGLYVPGG KAFYPSTVLM 150
    TAIPAKEAGV DEIILVTPPG ADGKIPAPTL AAAYIAGVDK VFACGGAQAV 200
    AALAFGTKSI PKVDKICGPG NIFVTLAKKA VFGVVDIDGL QGPSEVLILA 250
    DQYANAEYCA SDILAQAEHD VLASPIMVTT SAELAKRVND IVETKAGSCA 300
    RKDIIRQSLR DNGLIAVVDN MDEAIKLANM YATEHLCLLV KDSEQYLSRI 350
    NHAGCIFYGE KASVVMGDYV AGPSHALPTS GTARFSSPLN ILDFVKYIDI 400
    VNVSKEEVTK LGKAAVTIAR AEGLECHAEA ALKRME 436
    Length:436
    Mass (Da):46,836
    Last modified:September 27, 2005 - v1
    Checksum:iB5BDCD65764EA53F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000027 Genomic DNA. Translation: AAW39898.1.
    RefSeqiWP_010936572.1. NC_002936.3.
    YP_181571.1. NC_002936.3.

    Genome annotation databases

    EnsemblBacteriaiAAW39898; AAW39898; DET0844.
    GeneIDi3229860.
    KEGGidet:DET0844.
    PATRICi21608747. VBIDehEth89364_0802.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000027 Genomic DNA. Translation: AAW39898.1 .
    RefSeqi WP_010936572.1. NC_002936.3.
    YP_181571.1. NC_002936.3.

    3D structure databases

    ProteinModelPortali Q3Z878.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243164.DET0844.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW39898 ; AAW39898 ; DET0844 .
    GeneIDi 3229860.
    KEGGi det:DET0844.
    PATRICi 21608747. VBIDehEth89364_0802.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci DETH243164:GJNF-845-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-2266 / KCTC 15142 / 195.

    Entry informationi

    Entry nameiHISX_DEHM1
    AccessioniPrimary (citable) accession number: Q3Z878
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3