Reviewed, UniProtKB/Swiss-Prot Q3Z878 (HISX_DEHE1)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23

Gene names

Name:	hisD
Ordered Locus Names:	DET0844

Organism

Dehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]

Taxonomic identifier

243164 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024
Catalytic activity	L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01024
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Histidinol dehydrogenase HAMAP MF_01024		PRO_0000135764
Sites
	Active site	334	1	Proton acceptor By similarity
	Active site	335	1	Proton acceptor By similarity
	Metal binding	266	1	Zinc By similarity
	Metal binding	269	1	Zinc By similarity
	Metal binding	368	1	Zinc By similarity
	Metal binding	427	1	Zinc By similarity
	Binding site	136	1	NAD By similarity
	Binding site	198	1	NAD By similarity
	Binding site	221	1	NAD By similarity
	Binding site	244	1	Substrate By similarity
	Binding site	266	1	Substrate By similarity
	Binding site	269	1	Substrate By similarity
	Binding site	335	1	Substrate By similarity
	Binding site	368	1	Substrate By similarity
	Binding site	422	1	Substrate By similarity
	Binding site	427	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3Z878-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: B5BDCD65764EA53F	FASTA	436	46,836
	10 20 30 40 50 60 MEIIRGFAPA EKRLSRRDKA GFFLDETQRA ELAKRLGVDP EKAVNGIIDD IRKQGDKAVL 70 80 90 100 110 120 EYTLKFDRAA ISKLEVSPAE IKQAAGEIPA ELFEALKLAA TQVRAYHHFQ KEAVWKAAEI 130 140 150 160 170 180 MQGKQLIRPL ERVGLYVPGG KAFYPSTVLM TAIPAKEAGV DEIILVTPPG ADGKIPAPTL 190 200 210 220 230 240 AAAYIAGVDK VFACGGAQAV AALAFGTKSI PKVDKICGPG NIFVTLAKKA VFGVVDIDGL 250 260 270 280 290 300 QGPSEVLILA DQYANAEYCA SDILAQAEHD VLASPIMVTT SAELAKRVND IVETKAGSCA 310 320 330 340 350 360 RKDIIRQSLR DNGLIAVVDN MDEAIKLANM YATEHLCLLV KDSEQYLSRI NHAGCIFYGE 370 380 390 400 410 420 KASVVMGDYV AGPSHALPTS GTARFSSPLN ILDFVKYIDI VNVSKEEVTK LGKAAVTIAR 430 AEGLECHAEA ALKRME

References

[1]

"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes." Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H. , Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F. Science 307:105-108(2005) [PubMed: 15637277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000027 Genomic DNA. Translation: AAW39898.1.
RefSeq	YP_181571.1.
3D structure databases
SMR	Q3Z878. Positions 25-436.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3Z878.
Genome annotation databases
GeneID	3229860.
GenomeReviews	Gene locus DET0844 in contig CP000027_GR.
KEGG	det:DET0844.
NMPDR	fig|243164.3.peg.943.
TIGR	DET0844.
Phylogenomic databases
eggNOG	COG0141.
HOGENOM	HBG329596.
OMA	HRQRVPK.
PhylomeDB	Q3Z878.
Enzyme and pathway databases
BioCyc	DETH243164:DET_0844-MONOMER.
Family and domain databases
HAMAP	MF_01024. HisD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR001692. Histidinol_DH_CS. IPR012131. Hstdl_DH_prok-type. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX_DEHE1

Accession

Primary (citable) accession number: Q3Z878

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	September 27, 2005
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)