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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: TIGR
  • uracil phosphoribosyltransferase activity Source: TIGR

GO - Biological processi

  • nucleoside metabolic process Source: InterPro
  • pyrimidine-containing compound salvage Source: TIGR
  • pyrimidine ribonucleotide biosynthetic process Source: TIGR
  • regulation of transcription, DNA-templated Source: TIGR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciDETH243164:GJNF-1199-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:DET1198
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Bifunctional protein PyrRPRO_1000139192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243164.DET1198.

Structurei

3D structure databases

ProteinModelPortaliQ3Z788.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi98 – 11013PRPP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
OrthoDBiPOG091H02JM.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3Z788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKVILGAE DIRRTLARIA HEILERNHSS RDLVIIGMYT RGVPLANRLA
60 70 80 90 100
ENILRFEGLE IPVGTLDFSL YRDDLDSQRF HPTIKNTDIP FSINNKIVVL
110 120 130 140 150
VDDVLFTGRS TRAAMDALID YGRPKAIQLA VLVDRGHREL PVRADYIGKN
160 170 180
IPSSRDEKIK VRLTETDGRD EILILDNEAG EV
Length:182
Mass (Da):20,557
Last modified:September 27, 2005 - v1
Checksum:iDD40214173A45526
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW39556.1.
RefSeqiWP_010936888.1. NC_002936.3.

Genome annotation databases

EnsemblBacteriaiAAW39556; AAW39556; DET1198.
GeneIDi3229517.
KEGGidet:DET1198.
PATRICi21609431. VBIDehEth89364_1131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW39556.1.
RefSeqiWP_010936888.1. NC_002936.3.

3D structure databases

ProteinModelPortaliQ3Z788.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243164.DET1198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW39556; AAW39556; DET1198.
GeneIDi3229517.
KEGGidet:DET1198.
PATRICi21609431. VBIDehEth89364_1131.

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
OrthoDBiPOG091H02JM.

Enzyme and pathway databases

BioCyciDETH243164:GJNF-1199-MONOMER.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPYRR_DEHM1
AccessioniPrimary (citable) accession number: Q3Z788
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 27, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.