Q3Z782 (GCH1_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	DET1204

Organism

Dehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]

Taxonomic identifier

243164 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	GTP cyclohydrolase 1 HAMAP MF_00223		PRO_1000043687
Sites
	Metal binding	76	1	Zinc By similarity
	Metal binding	79	1	Zinc By similarity
	Metal binding	149	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3Z782 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: CC03BE97DE462B0C	FASTA	189	21,170
	10 20 30 40 50 60 MFDEQAIKQS VQNMLLAIGE DPEREGLKET PRRVAQMYAE LFSGMNQDPA EVLRVGYELG 70 80 90 100 110 120 HREMVIIKDI PFYSMCEHHL LPFSGVVHIG YIPNIDGRVV GISKLARVVE IYAKRPQIQE 130 140 150 160 170 180 RMATQIADAI IDGLKCDGVA VVIEAEHMCM VMRGIKKPGS RVITSALRGS FHKSPAARAE FLSLIQQKH

References

[1]

"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes." Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H. , Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F. Science 307:105-108(2005) [PubMed: 15637277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000027 Genomic DNA. Translation: AAW39542.1.
RefSeq	YP_181917.1. NC_002936.3.
3D structure databases
HSSP	HSSP built from PDB template 1WM9 based on UniProtKB Q5SH52.
ProteinModelPortal	Q3Z782.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3Z782.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3229503.
GenomeReviews	Gene locus DET1204 in contig CP000027_GR.
KEGG	det:DET1204.
NMPDR	fig|243164.3.peg.1106.
PATRIC	21609443. VBIDehEth89364_1137.
TIGR	DET1204.
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HBG370191.
OMA	KQIATAM.
PhylomeDB	Q3Z782.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	DETH243164:DET_1204-MONOMER.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_DEHE1

Accession

Primary (citable) accession number: Q3Z782

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program