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Q3Z731 (ARGJ_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arginine biosynthesis bifunctional protein ArgJ

Cleaved into the following 2 chains:

  1. Arginine biosynthesis bifunctional protein ArgJ alpha chain
  2. Arginine biosynthesis bifunctional protein ArgJ beta chain

Including the following 2 domains:

  1. Glutamate N-acetyltransferase
    EC=2.3.1.35
    Alternative name(s):
    Ornithine acetyltransferase
    Short name=OATase
    Ornithine transacetylase
  2. Amino-acid acetyltransferase
    EC=2.3.1.1
    Alternative name(s):
    N-acetylglutamate synthase
    Short name=AGS
Gene names
Name:argJ
Ordered Locus Names:DET1256
OrganismDehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]
Taxonomic identifier243164 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate By similarity. HAMAP MF_01106

Catalytic activity

N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate. HAMAP MF_01106

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01106

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1. HAMAP MF_01106

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01106

Subunit structure

Heterotetramer of two alpha and two beta chains By similarity.

Subcellular location

Cytoplasm Probable HAMAP MF_01106.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. HAMAP MF_01106

Sequence similarities

Belongs to the ArgJ family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Arginine biosynthesis bifunctional protein ArgJ alpha chain By similarity
PRO_0000227224
Chain192 – 405214Arginine biosynthesis bifunctional protein ArgJ beta chain By similarity
PRO_0000227225

Sites

Site191 – 1922Cleavage; by autolysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3Z731 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 538BA4437A3B50B6

FASTA40543,305
        10         20         30         40         50         60 
MKSSIDILPD GSITTPKGFK TGAIYAGIKK KSKNNLDLTI LYSDTPCVAA GIFTTNKFRA 

        70         80         90        100        110        120 
APVYISEHNL GFPDNRAIVV NSGCANAGTG EAGMADAIEM VKTTAETLNM QPKDVLIAST 

       130        140        150        160        170        180 
GVIGHRLPMD KIKESIRLIG LSQRNGHDFA RAIMTTDTRS KEIAVRVNIE GFQFYIAGAA 

       190        200        210        220        230        240 
KGAGMIHPNM ATLLGFITTD ASVSKDFLQF ALKEAADISF NMITVDGDTS TNDSLFMLAN 

       250        260        270        280        290        300 
GQAENPTFAG DTEYSLVFQQ ALNIVCQSLA KSVARDGEGA KRLIEIQVEG AASLEDARLI 

       310        320        330        340        350        360 
ARAVAGSPLV KTAVHGADPN WGRILAAAGR SGADFDIERV DLYLGESRVL QKGQRTGADE 

       370        380        390        400 
KELSSWLKQV EVIIKLNLNL GEGKSTAWGC DLSAEYVKIN ADYTT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000027 Genomic DNA. Translation: AAW39483.1.
RefSeqYP_181968.1. NC_002936.3.

3D structure databases

ProteinModelPortalQ3Z731.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3Z731.

Protein family/group databases

MEROPST05.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3229443.
GenomeReviewsGene locus DET1256 in contig CP000027_GR.
KEGGdet:DET1256.
NMPDRfig|243164.3.peg.1204.
PATRIC21609539. VBIDehEth89364_1185.
TIGRDET1256.

Phylogenomic databases

eggNOGCOG1364.
HOGENOMHBG284202.
OMAGRDPNWG.
PhylomeDBQ3Z731.
ProtClustDBPRK05388.

Enzyme and pathway databases

BioCycDETH243164:DET_1256-MONOMER.

Family and domain databases

HAMAPMF_01106. ArgJ.
[Tree]
InterProIPR002813. Arg_biosynth_ArgJ.
IPR016117. Pept_S58_DmpA/Arg_biosyn_ArgJ.
[Graphical view]
KOK00620.
PANTHERPTHR23100. ArgJ. 1 hit.
PfamPF01960. ArgJ. 1 hit.
[Graphical view]
ProDomPD004193. Arg_biosynth_ArgJ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF56266. Pept_S58_DmpA/Arg_biosyn_ArgJ. 1 hit.
TIGRFAMsTIGR00120. ArgJ. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARGJ_DEHE1
AccessionPrimary (citable) accession number: Q3Z731
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 27, 2005
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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