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Q3Z727

- ASSY_DEHM1

UniProt

Q3Z727 - ASSY_DEHM1

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Protein
Argininosuccinate synthase
Gene
argG, DET1260
Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861Citrulline By similarity
Binding sitei116 – 1161ATP; via amide nitrogen By similarity
Binding sitei118 – 1181Aspartate By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei122 – 1221Citrulline By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei174 – 1741Citrulline By similarity
Binding sitei183 – 1831Citrulline By similarity
Binding sitei259 – 2591Citrulline By similarity
Binding sitei271 – 2711Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDETH243164:GJNF-1261-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:DET1260
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000008289: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Argininosuccinate synthaseUniRule annotation
PRO_0000263918Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243164.DET1260.

Structurei

3D structure databases

ProteinModelPortaliQ3Z727.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3Z727-1 [UniParc]FASTAAdd to Basket

« Hide

MSEKVVLAYS GGLDTSAAVK WLQEKYGMDV IAVTIDVGNE KDFTLIKEKA    50
LKVGAKKAYV RDVRKEFAED YIWKAIKANS MYEGVYPLAT ALARPLIAKV 100
MVDIAMEEGA TAIAHGCTGK GNDQVRFDVG INTLAPHLKI IAPARQWGMT 150
REQTMEYAQK WGIPVPISVK NPFSIDENLW GRSIECGLLE DPWNEPIPEV 200
FAWTRPVEAT PDAPEYLEVE FEQGVPVAVN GEKLSPLALI QKVHDIAGLH 250
GVGRIDHVEN RLVGIKSREI YEAPAAVVLI AAHQALEAMT LSKSQLRFKQ 300
MVEATYSDII YNGLWFSALR QDLDAFIESS QRFVSGTVRL KLSKGSFRVV 350
GRKSPYSLYH KGMATYDKGD QFDPSSAVGF ITLWGLQAKL QAQLQPILEE 400
EKGNKS 406
Length:406
Mass (Da):45,044
Last modified:September 27, 2005 - v1
Checksum:i8FB43CE1B0AB9226
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000027 Genomic DNA. Translation: AAW39470.1.
RefSeqiYP_181972.1. NC_002936.3.

Genome annotation databases

EnsemblBacteriaiAAW39470; AAW39470; DET1260.
GeneIDi3229430.
KEGGidet:DET1260.
PATRICi21609547. VBIDehEth89364_1189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000027 Genomic DNA. Translation: AAW39470.1 .
RefSeqi YP_181972.1. NC_002936.3.

3D structure databases

ProteinModelPortali Q3Z727.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243164.DET1260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW39470 ; AAW39470 ; DET1260 .
GeneIDi 3229430.
KEGGi det:DET1260.
PATRICi 21609547. VBIDehEth89364_1189.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci DETH243164:GJNF-1261-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-2266 / KCTC 15142 / 195.

Entry informationi

Entry nameiASSY_DEHM1
AccessioniPrimary (citable) accession number: Q3Z727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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