ID   RNPH_DEHE1              Reviewed;         239 AA.
AC   Q3Z6Z8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Ribonuclease PH;
DE            Short=RNase PH;
DE            EC=2.7.7.56;
DE   AltName: Full=tRNA nucleotidyltransferase;
GN   Name=rph; OrderedLocusNames=DET1289;
OS   Dehalococcoides ethenogenes (strain 195).
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M.,
RA   Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M.,
RA   Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M.,
RA   Sullivan S.A., Madupu R., Nelson K.E., Kang K.H., Impraim M., Tran K.,
RA   Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H.,
RA   Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- FUNCTION: Phosphorolytic exoribonuclease that removes nucleotide
CC       residues following the -CCA terminus of tRNA and adds nucleotides
CC       to the ends of RNA molecules by using nucleoside diphosphates as
CC       substrates (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside
CC       diphosphate.
CC   -!- SIMILARITY: Belongs to the RNase PH family.
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DR   EMBL; CP000027; AAW39419.1; -; Genomic_DNA.
DR   RefSeq; YP_182001.1; -.
DR   GeneID; 3229379; -.
DR   GenomeReviews; CP000027_GR; DET1289.
DR   KEGG; det:DET1289; -.
DR   NMPDR; fig|243164.3.peg.1282; -.
DR   TIGR; DET1289; -.
DR   HOGENOM; Q3Z6Z8; -.
DR   OMA; Q3Z6Z8; YAMLPRA.
DR   BioCyc; DETH243164:DET_1289-MON; -.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:HAMAP.
DR   GO; GO:0009022; F:tRNA nucleotidyltransferase activity; IEA:HAMAP.
DR   GO; GO:0004549; F:tRNA-specific ribonuclease activity; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:HAMAP.
DR   HAMAP; MF_00564; -; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR018336; Ribonuclease-PH_CS.
DR   InterPro; IPR002381; RNase_PH_bac-type.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   TIGRFAMs; TIGR01966; RNasePH; 1.
DR   PROSITE; PS01277; RIBONUCLEASE_PH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Nucleotidyltransferase; Transferase;
KW   tRNA processing.
FT   CHAIN         1    239       Ribonuclease PH.
FT                                /FTId=PRO_1000061131.
SQ   SEQUENCE   239 AA;  26385 MW;  144941419CF0BB1E CRC64;
     MQRGDGRNFN QLRPITITPG FQSFAEGSVL IEQGKTRVIC SVSMEDKVPQ FLRNSGTGWV
     TAEYSMLPRS TVTRTQRDSS AGKISGRSQE IQRLIGRSLR SCVDLAALGE RSFIIDCDVI
     QADAGTRTAS ITGAYIALYL AFKKMVDMGI LSKMPFTSQV AAVSVSIFKG NIVLDPCYDE
     DFQAEVDFNL VMNDRAEFVE IQGTAEGKTF SRDTLDQVLK LGEAGIWQLF DIQNSITRP
//