Q3Z6W5 (COAE_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase
EC=2.7.1.24

Alternative name(s):
Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	DET1323

Organism

Dehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]

Taxonomic identifier

243164 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity HAMAP MF_00376.
Sequence similarities	Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dephospho-CoA kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Dephospho-CoA kinase HAMAP MF_00376		PRO_0000243280
Regions
	Domain	3 – 198	196	DPCK
	Nucleotide binding	8 – 15	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3Z6W5 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: EA85547D8461591B	FASTA	198	22,320
	10 20 30 40 50 60 MKIVGITGGI GSGKTTVCRY LKELGVNIID ADEIGHRVLQ NKGIRTRITD VFGNEVMNPD 70 80 90 100 110 120 GSINRKILGE LVFGYPERLE HLNKITHPLI EQAIASLLEE YRQKGIKAVA IEAPLLVEAG 130 140 150 160 170 180 WLKLVNEVWL ITAPKESIFK RLRNRMGLSR EQVMARIQSQ ATDNERLKYA SIVINNNCRF 190 EDLKSCVQLL AKERLELA

References

[1]

"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes." Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H. , Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F. Science 307:105-108(2005) [PubMed: 15637277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000027 Genomic DNA. Translation: AAW39462.1.
RefSeq	YP_182034.1. NC_002936.3.
3D structure databases
ProteinModelPortal	Q3Z6W5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3Z6W5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3229422.
GenomeReviews	Gene locus DET1323 in contig CP000027_GR.
KEGG	det:DET1323.
NMPDR	fig|243164.3.peg.487.
PATRIC	21609675. VBIDehEth89364_1252.
TIGR	DET1323.
Phylogenomic databases
eggNOG	COG0237.
HOGENOM	HBG650290.
OMA	YVIMVVP.
PhylomeDB	Q3Z6W5.
ProtClustDB	PRK00081.
Enzyme and pathway databases
BioCyc	DETH243164:DET_1323-MONOMER.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
KO	K00859.
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_DEHE1

Accession

Primary (citable) accession number: Q3Z6W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program