Q3Z6L5 (GCP_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp

Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein

Gene names

Name:	gcp
Ordered Locus Names:	DET1426

Organism

Dehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]

Taxonomic identifier

243164 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine By similarity. HAMAP MF_01445
Subcellular location	Cytoplasm Potential HAMAP MF_01445.
Sequence similarities	Belongs to the KAE1 / YgjD family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp HAMAP MF_01445		PRO_0000303343

Sequences

	Sequence		Length	Mass (Da)
	Q3Z6L5 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 255F11E25904ABC9	FASTA	326	34,119
	10 20 30 40 50 60 MKILGIESSC DETAAAVVAD GVNILSNRVS SQIDIHSRYG GVVPEVASRQ HLLSILPVIS 70 80 90 100 110 120 DALKEARTGF DEISAIAVTN GPGLAGSLIV GVNAAKAIAA ARGIPLVAVN HLHGHIYANW 130 140 150 160 170 180 LSGRIPEFPC LCLTVSGGHT DLVLMKGHGQ YQLLGRTRDD AAGEAFDKAA RILGLSYPGG 190 200 210 220 230 240 PAIDRASQDG EAVLDLPRSW IPGSHDFSFS GLKTALLRLV ENGEVCSVND AAASFQKAVV 250 260 270 280 290 300 DVLVTKTLNC AHEYNVKQIL LAGGVAANNL LRKQLSEQSP LPVSIPPIGL CTDNAAVIAS 310 320 CGYFRFISGG QDRLDMDVLP ALSVVS

References

[1]

"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes." Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H. , Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F. Science 307:105-108(2005) [PubMed: 15637277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000027 Genomic DNA. Translation: AAW39287.1.
RefSeq	YP_182134.1. NC_002936.3.
3D structure databases
ProteinModelPortal	Q3Z6L5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3Z6L5.
Protein family/group databases
MEROPS	M22.A01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3229245.
GenomeReviews	Gene locus DET1426 in contig CP000027_GR.
KEGG	det:DET1426.
NMPDR	fig|243164.3.peg.1394.
PATRIC	21609879. VBIDehEth89364_1353.
TIGR	DET1426.
Phylogenomic databases
eggNOG	COG0533.
HOGENOM	HBG304663.
OMA	PAVGVHH.
PhylomeDB	Q3Z6L5.
ProtClustDB	PRK09604.
Enzyme and pathway databases
BioCyc	DETH243164:DET_1426-MONOMER.
Family and domain databases
HAMAP	MF_01445. gcp. [Tree]
InterPro	IPR022450. Pept_M22_O-sialoglycopept. IPR000905. Peptidase_M22. IPR017861. Peptidase_M22_subgr. [Graphical view]
KO	K01409.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR03723. Bact_gcp. 1 hit. TIGR00329. Gcp_kae1. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_DEHE1

Accession

Primary (citable) accession number: Q3Z6L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program