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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Mg2+Note: Binds 2 magnesium ions per monomer.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD-1), Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79Anthranilate 1; via carbonyl oxygen1
Binding sitei79Phosphoribosylpyrophosphate; via amide nitrogen1
Binding sitei87Phosphoribosylpyrophosphate1
Metal bindingi91Magnesium 11
Binding sitei110Anthranilate 11
Binding sitei119Phosphoribosylpyrophosphate; via amide nitrogen1
Binding sitei165Anthranilate 21
Metal bindingi224Magnesium 21
Metal bindingi225Magnesium 11
Metal bindingi225Magnesium 21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferase (EC:2.4.2.18)
Gene namesi
Name:trpD
Ordered Locus Names:DET1483
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002271531 – 341Anthranilate phosphoribosyltransferaseAdd BLAST341

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi243164.DET1483.

Structurei

3D structure databases

ProteinModelPortaliQ3Z6G6.
SMRiQ3Z6G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 83Phosphoribosylpyrophosphate binding2
Regioni89 – 92Phosphoribosylpyrophosphate binding4
Regioni107 – 115Phosphoribosylpyrophosphate binding9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.

Phylogenomic databases

eggNOGiENOG4107QYG. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiLCALKIK.
OrthoDBiPOG091H01QX.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiView protein in InterPro
IPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR036320. Glycosyl_Trfase_fam3_N_dom)sf.
IPR035902. Nuc_phospho_transferase.
PfamiView protein in Pfam
PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3Z6G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKEAIGSLV LGKSLTLEQS ASVMDEIMEG KTTPAQIGAF LTALRVKGET
60 70 80 90 100
AEEIAGLANV MRAKSTRIST STPVLDIVGI GGDGINTFNI STTAAFVISG
110 120 130 140 150
AGIKVAKHGN RAASSMCGSA DVLEALGIKI DLNAEQVKIC IEQIGIGFMF
160 170 180 190 200
APVFHPAMKF VAPSRREIGI RTVFNILGPL TNPASAQYQL IGVPEIGLGD
210 220 230 240 250
KIISALCHMD IKHALVVHGL DGMDEMSISG DSVIWELKDK EIIKFRHTVS
260 270 280 290 300
PREMGLEQVS LQAVKGGAAE ENALTLRAIL SGAKGPKRDV VLLNAAAALM
310 320 330 340
VADKIDTIAE GISLAAEIID NGLALNKLES LIKLSQSLAS G
Length:341
Mass (Da):35,748
Last modified:September 27, 2005 - v1
Checksum:i8445ACAFB3A7017C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW39329.1.
RefSeqiWP_010937160.1. NC_002936.3.

Genome annotation databases

EnsemblBacteriaiAAW39329; AAW39329; DET1483.
GeneIDi29935100.
KEGGidet:DET1483.

Similar proteinsi

Entry informationi

Entry nameiTRPD_DEHM1
AccessioniPrimary (citable) accession number: Q3Z6G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 27, 2005
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families