Q3Z6G5 (TRPC_DEHE1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	DET1484

Organism

Dehalococcoides ethenogenes (strain 195) [Complete proteome] [HAMAP]

Taxonomic identifier

243164 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018477

Sequences

	Sequence		Length	Mass (Da)
	Q3Z6G5 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: BF0FCA0276D82386	FASTA	259	28,997
	10 20 30 40 50 60 MILERIVTDN LPDLERRKMR LPLAKLQELV LDIPYLPIDM AMKLKGRQVR LIAEVKKASP 70 80 90 100 110 120 SKGIIRPDFD PVDIAGIYAR NGASAISVLT EEHHFMGSLD NLKKIRESGV ASKLPLLRKD 130 140 150 160 170 180 FIHDPYQVYE SRLYGADAIL LIVAMLSPER LQELLSLSHK LGMKCLVEVH TRSELEIALE 190 200 210 220 230 240 SNARIIGLNN RDLHTFKIDL TVTERLRPLI PPECIVVSES GIQTRADISR LEELGVDAVL 250 VGEALTASVD IAAKMRELL

References

[1]

"Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes." Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E., Kang K.H. , Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H., Heidelberg J.F. Science 307:105-108(2005) [PubMed: 15637277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000027 Genomic DNA. Translation: AAW39328.1.
RefSeq	YP_182184.1. NC_002936.3.
3D structure databases
HSSP	HSSP built from PDB template 1J5T based on UniProtKB Q56319.
ProteinModelPortal	Q3Z6G5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3Z6G5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3229286.
GenomeReviews	Gene locus DET1484 in contig CP000027_GR.
KEGG	det:DET1484.
NMPDR	fig|243164.3.peg.1409.
PATRIC	21609990. VBIDehEth89364_1400.
TIGR	DET1484.
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
OMA	MRKDDVT.
PhylomeDB	Q3Z6G5.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	DETH243164:DET_1484-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_DEHE1

Accession

Primary (citable) accession number: Q3Z6G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program