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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotationSAAS annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD-1), Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotationImported
Ordered Locus Names:DET1487Imported
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))Imported
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi243164.DET1487.

Structurei

3D structure databases

ProteinModelPortaliQ3Z6G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 382PALPInterPro annotationAdd BLAST326

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CG0. Bacteria.
COG0133. LUCA.
HOGENOMiHOG000161710.
KOiK01696.
OMAiPEMLYPN.
OrthoDBiPOG091H02JY.

Family and domain databases

CDDicd06446. Trp-synth_B. 1 hit.
HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiView protein in InterPro
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
PfamiView protein in Pfam
PF00291. PALP. 1 hit.
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiView protein in PROSITE
PS00168. TRP_SYNTHASE_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3Z6G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKVDSTGKP GYFGKYGGQF VPEILVPVLN ELEQAYEQAK KDETFQSRLK
60 70 80 90 100
SLSNTFSGRP TPLYLAERLT EHLGGARIYL KREDLAHTGA HKINNALGQG
110 120 130 140 150
LLALHMGKKR VIAETGAGQH GVATAAVCAM LGLECIVYMG EDDIKRQALN
160 170 180 190 200
VFRMKLMGTE VRSVSSGSRT LKDAINEAMR DWVSNPETTY YIIGSVVGPR
210 220 230 240 250
PYPAMVRDFQ AVIGQETKAQ SLRQLGGLPD CIVACVGGGS NAMGIFYDFI
260 270 280 290 300
PDQSVRLIGV EAAGSGISTG KHSATLSAGK VGILHGAMSY LLQDEHGQVI
310 320 330 340 350
ETHSISAGLD YPGVGPEHSY LKDNKRVEYV SVTDEEALNG FKLLCSLEGI
360 370 380 390
MPALESSHAI AHALKIAVGM PKNKNIVINL SGRGDKDMDI VQKAMGVKI
Length:399
Mass (Da):42,915
Last modified:September 27, 2005 - v1
Checksum:i0BC838FBADFA9DDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA. Translation: AAW39325.1.
RefSeqiWP_010937164.1. NC_002936.3.

Genome annotation databases

EnsemblBacteriaiAAW39325; AAW39325; DET1487.
KEGGidet:DET1487.
PATRICifig|243164.10.peg.1403.

Similar proteinsi

Entry informationi

Entry nameiQ3Z6G2_DEHM1
AccessioniPrimary (citable) accession number: Q3Z6G2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 27, 2005
Last sequence update: September 27, 2005
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported