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Protein

Quinolinate synthase A

Gene

nadA

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24IminoaspartateUniRule annotation1
Binding sitei41Iminoaspartate; via amide nitrogenUniRule annotation1
Binding sitei112IminoaspartateUniRule annotation1
Binding sitei129IminoaspartateUniRule annotation1
Binding sitei197IminoaspartateUniRule annotation1
Binding sitei214IminoaspartateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyridine nucleotide biosynthesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciDMCC243164:G1G45-1531-MONOMER
UniPathwayiUPA00253; UER00327

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:DET1590
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195) (Dehalococcoides ethenogenes (strain 195))
Taxonomic identifieri243164 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
Proteomesi
  • UP000008289 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000725721 – 302Quinolinate synthase AAdd BLAST302

Interactioni

Protein-protein interaction databases

STRINGi243164.DET1590

Structurei

3D structure databases

ProteinModelPortaliQ3Z663
SMRiQ3Z663
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0I Bacteria
COG0379 LUCA
HOGENOMiHOG000222770
KOiK03517
OMAiLWAPDRH
OrthoDBiPOG091H03D2

Family and domain databases

HAMAPiMF_00568 NadA_type2, 1 hit
InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
IPR023066 Quinolinate_synth_type2
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit

Sequencei

Sequence statusi: Complete.

Q3Z663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTELISHKI AELKKERKAV ILAHNYQLGE IQEAADFVGD SLELARKAAN
60 70 80 90 100
IDAEVIVFCG VHFMAETAAI LSPEKTVLAP EPKAGCPMAD MISGAELREF
110 120 130 140 150
KARYPGLPVV CYVNSTAEVK AESDICCTSA NAVKVVESLK SDTVLFVPDQ
160 170 180 190 200
YLGAFVQAHT AKKIISWPGY CPCHARIKPE DILNLKKHYP KAKVVVHPES
210 220 230 240 250
RPEVTALADG VLSTGQMVTY AARADVKELI VGTEIGMLYR LRKENPNKLF
260 270 280 290 300
IPVSEQAVCA NMKMTTLPKL LASLENMQTV VSVPEEIRRK AVGAVERMLK

VT
Length:302
Mass (Da):33,123
Last modified:September 27, 2005 - v1
Checksum:iD8AB81E5362F286A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000027 Genomic DNA Translation: AAW39153.1
RefSeqiWP_010937262.1, NC_002936.3

Genome annotation databases

EnsemblBacteriaiAAW39153; AAW39153; DET1590
GeneIDi3229111
KEGGidet:DET1590
PATRICifig|243164.10.peg.1500

Similar proteinsi

Entry informationi

Entry nameiNADA_DEHM1
AccessioniPrimary (citable) accession number: Q3Z663
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 27, 2005
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health