ID   MHPE_SHISS              Reviewed;         337 AA.
AC   Q3Z554;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=4-hydroxy-2-oxovalerate aldolase;
DE            Short=HOA;
DE            EC=4.1.3.39;
DE   AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase;
GN   Name=mhpE; OrderedLocusNames=SSON_0331;
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X.,
RA   Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S.,
RA   Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y.,
RA   Qiang B., Hou Y., Yu J., Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic
RT   agents of bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Catalyzes the fission of 4-hydroxy-2-ketovalerate to
CC       yield pyruvate and acetaldehyde (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxy-2-oxopentanoate = acetaldehyde +
CC       pyruvate.
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropionic acid
CC       degradation.
CC   -!- SUBUNIT: Interacts with mhpF (By similarity).
CC   -!- SIMILARITY: Belongs to the mhpE aldolase family.
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DR   EMBL; CP000038; AAZ87108.1; -; Genomic_DNA.
DR   RefSeq; YP_309343.1; -.
DR   SMR; Q3Z554; 4-333.
DR   GeneID; 3668930; -.
DR   GenomeReviews; CP000038_GR; SSON_0331.
DR   KEGG; ssn:SSON_0331; -.
DR   HOGENOM; Q3Z554; -.
DR   OMA; Q3Z554; ATCVYVV.
DR   BioCyc; SSON300269:SSO_0331-MON; -.
DR   GO; GO:0008701; F:4-hydroxy-2-oxovalerate aldolase activity; IEA:HAMAP.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:HAMAP.
DR   HAMAP; MF_01656; -; 1.
DR   InterPro; IPR017629; 4OH_2_O-val_aldolase.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012425; DmpG_comm.
DR   InterPro; IPR000891; PYR_CT.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF07836; DmpG_comm; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   TIGRFAMs; TIGR03217; 4OH_2_O_val_ald; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Complete proteome; Lyase.
FT   CHAIN         1    337       4-hydroxy-2-oxovalerate aldolase.
FT                                /FTId=PRO_0000337808.
SQ   SEQUENCE   337 AA;  36502 MW;  A2B4F6A1598DB91A CRC64;
     MNGKKLYISD VTLRDGMHAI RHQYSLENVR QIAKALDDAR VDSIEVAHGD GLQGSSFNYG
     FGAHSDLEWI EAAADVVRHA KIATLLLPGI GTIHDLKNAW QAGARVVRVA THCTEADVSA
     QHIQYARELG MDTVGFLMMS HMTTPENLAK QAKLMEGYGA TCIYVVDSGG AMNMSDIRDR
     FRALKAVLKP ETQTGMHAHH NLSLGVANSI AAVEEGCDRI DASFAGMGAG AGNAPLEVFI
     AAADKLGWQH GTDLYALMDA ADDLVRPLQD RPVRVDRETL ALGYAGVYSS FLRHCETAAA
     RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLRNNK
//