Reviewed, UniProtKB/Swiss-Prot Q3Z554 (MHPE_SHISS)

Names and origin

Protein names

Recommended name:
    4-hydroxy-2-oxovalerate aldolase
      Short name=HOA
    EC=4.1.3.39
Alternative name(s):
    4-hydroxy-2-keto-pentanoic acid aldolase

Gene names

Name:	mhpE
Ordered Locus Names:	SSON_0331

Organism

Shigella sonnei (strain Ss046) [Complete proteome] [HAMAP]

Taxonomic identifier

300269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the fission of 4-hydroxy-2-ketovalerate to yield pyruvate and acetaldehyde By similarity.
Catalytic activity	4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. HAMAP MF_01656
Pathway	Aromatic compound metabolism; 3-phenylpropionic acid degradation. HAMAP MF_01656
Subunit structure	Interacts with mhpF By similarity.
Sequence similarities	Belongs to the mhpE aldolase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4-hydroxy-2-oxovalerate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	4-hydroxy-2-oxovalerate aldolase HAMAP MF_01656		PRO_0000337808

Sequences

	Sequence		Length	Mass (Da)
	Q3Z554-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: A2B4F6A1598DB91A	FASTA	337	36,502
	10 20 30 40 50 60 MNGKKLYISD VTLRDGMHAI RHQYSLENVR QIAKALDDAR VDSIEVAHGD GLQGSSFNYG 70 80 90 100 110 120 FGAHSDLEWI EAAADVVRHA KIATLLLPGI GTIHDLKNAW QAGARVVRVA THCTEADVSA 130 140 150 160 170 180 QHIQYARELG MDTVGFLMMS HMTTPENLAK QAKLMEGYGA TCIYVVDSGG AMNMSDIRDR 190 200 210 220 230 240 FRALKAVLKP ETQTGMHAHH NLSLGVANSI AAVEEGCDRI DASFAGMGAG AGNAPLEVFI 250 260 270 280 290 300 AAADKLGWQH GTDLYALMDA ADDLVRPLQD RPVRVDRETL ALGYAGVYSS FLRHCETAAA 310 320 330 RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLRNNK

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000038 Genomic DNA. Translation: AAZ87108.1.
RefSeq	YP_309343.1.
3D structure databases
SMR	Q3Z554. Positions 4-333.
ModBase	Search...
Genome annotation databases
GeneID	3668930.
GenomeReviews	Gene locus SSON_0331 in contig CP000038_GR.
KEGG	ssn:SSON_0331.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3Z554.
OMA	Q3Z554. ATCVYVV.
Enzyme and pathway databases
BioCyc	SSON300269:SSO_0331-MON.
Family and domain databases
HAMAP	MF_01656. [Tree]
InterPro	IPR017629. 4OH_2_O-val_aldolase. IPR013785. Aldolase_TIM. IPR012425. DmpG_comm. IPR000891. PYR_CT. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF07836. DmpG_comm. 1 hit. PF00682. HMGL-like. 1 hit. [Graphical view]
TIGRFAMs	TIGR03217. 4OH_2_O_val_ald. 1 hit.
PROSITE	PS50991. PYR_CT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MHPE_SHISS

Accession

Primary (citable) accession number: Q3Z554

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)