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Protein

Thiamine kinase

Gene

thiK

Organism
Shigella sonnei (strain Ss046)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of thiamine to thiamine phosphate.UniRule annotation

Catalytic activityi

ATP + thiamine = ADP + thiamine phosphate.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes thiamine phosphate from thiamine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Thiamine kinase (thiK)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine phosphate from thiamine, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00596

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine kinaseUniRule annotation (EC:2.7.1.89UniRule annotation)
Gene namesi
Name:thiKUniRule annotation
Ordered Locus Names:SSON_1126
OrganismiShigella sonnei (strain Ss046)
Taxonomic identifieri300269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002529 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002910021 – 274Thiamine kinaseAdd BLAST274

Structurei

3D structure databases

ProteinModelPortaliQ3Z311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiamine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219316
KOiK07251
OMAiDVHAGNI

Family and domain databases

HAMAPiMF_01604 Thiamine_kinase, 1 hit
InterProiView protein in InterPro
IPR002575 Aminoglycoside_PTrfase
IPR011009 Kinase-like_dom_sf
IPR014093 Thiamine_kinase
PfamiView protein in Pfam
PF01636 APH, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR02721 ycfN_thiK, 1 hit

Sequencei

Sequence statusi: Complete.

Q3Z311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFRSNNPIT RDELLSRFFP QFHPVTTFNS GLSGGSFLIE HQGQRFVVRQ
60 70 80 90 100
PHDPDAPQSA FLRQYRALSQ LPASIAPKPH LYLRDWMVVD YLPGAVKTYL
110 120 130 140 150
PDTNELAGLL YYLHQQPRFG WRITLLPLLE LYWQQSDPAR RTVGWLRMLK
160 170 180 190 200
RLRKAREPRP LRLSPLHMDV HAGNLVHSAS GLKLIDWEYA GDGDIALELA
210 220 230 240 250
AVWVENTEQH RQLVNDYATR AKIYPAQLWR QVRRWFPWLL MLKAGWFEYR
260 270
WRQIGDQQFI RLADDTWRQL LIKQ
Length:274
Mass (Da):32,377
Last modified:September 27, 2005 - v1
Checksum:i7B8DE5BC58B324D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000038 Genomic DNA Translation: AAZ87851.1

Genome annotation databases

EnsemblBacteriaiAAZ87851; AAZ87851; SSON_1126
KEGGissn:SSON_1126

Similar proteinsi

Entry informationi

Entry nameiTHIK_SHISS
AccessioniPrimary (citable) accession number: Q3Z311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 27, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health