Q3Z1Z2 (PDXY_SHISS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyridoxamine kinase
Short name=PM kinase
EC=2.7.1.35

Gene names

Name:	pdxY
Ordered Locus Names:	SSON_1520

Organism

Shigella sonnei (strain Ss046) [Complete proteome] [HAMAP]

Taxonomic identifier

300269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine By similarity. HAMAP MF_01639
Catalytic activity	ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01639
Sequence similarities	Belongs to the pyridoxine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridoxal 5'-phosphate salvage Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Pyridoxamine kinase HAMAP MF_01639		PRO_0000269833
Regions
	Nucleotide binding	182 – 183	2	ATP By similarity
	Nucleotide binding	208 – 223	16	ATP By similarity
Sites
	Binding site	10	1	Substrate By similarity
	Binding site	45	1	Substrate By similarity
	Binding site	224	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3Z1Z2 [UniParc]. Last modified January 15, 2008. Version 3. Checksum: CD1316499BDCDFA1	FASTA	287	31,350
	10 20 30 40 50 60 MMKNILAIQS HVVYGHAGNS AAEFPMRRLG ANVWPLNTVQ FSNHTQYGKW TGCVMPPSHL 70 80 90 100 110 120 TEIVQGIAAI DKLHTCDAVL SGYLGSAEQG EHILGIVRQV KAANPQAKYF CDPVMGHPEK 130 140 150 160 170 180 GCIVAPGVAE FHVRHGLPAS DIIAPNLVEL EILCEHAVNN VEEAVLAARE LIAQGPQIVL 190 200 210 220 230 240 VKHLARAGYS RDRFEMLLVT ADEAWHISRP LVDFGMRQPV GVGDVTSGLL LVKLLQGATL 250 260 270 280 QEVLEHVTAA VYEIMVTTKA MQEYELQVVA AQDRIAKPEH YFSATKL

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ss046.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000038 Genomic DNA. Translation: AAZ88220.1.
RefSeq	YP_310455.1. NC_007384.1.
3D structure databases
HSSP	HSSP built from PDB template 1YGJ based on UniProtKB P82197.
ProteinModelPortal	Q3Z1Z2.
SMR	Q3Z1Z2. Positions 1-287.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3Z1Z2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000101640; EBESCP00000097669; EBESCG00000100684.
GeneID	3667165.
GenomeReviews	Gene locus SSON_1520 in contig CP000038_GR.
KEGG	ssn:SSON_1520.
PATRIC	18736934. VBIShiSon107113_1815.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2240.
GeneTree	EBGT00050000009567.
HOGENOM	HBG661459.
OMA	CPNQLEL.
ProtClustDB	PRK05756.
Enzyme and pathway databases
BioCyc	SSON300269:SSO_1520-MONOMER.
Family and domain databases
HAMAP	MF_01639. PdxY. [Tree]
InterPro	IPR013749. HMP-P_kinase-1. IPR004625. PyrdxlP_synth_PyrdxlKinase. IPR023685. Pyridoxal_kinase_PdxY. [Graphical view]
KO	K00868.
PANTHER	PTHR10534. PTHR10534. 1 hit.
Pfam	PF08543. Phos_pyr_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00687. Pyridox_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDXY_SHISS

Accession

Primary (citable) accession number: Q3Z1Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program