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Q3Z1V9

- FOLM_SHISS

UniProt

Q3Z1V9 - FOLM_SHISS

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Protein

Dihydrofolate reductase FolM

Gene

folM

Organism
Shigella sonnei (strain Ss046)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of dihydrofolate to tetrahydrofolate.By similarity

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. dihydrofolate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. one-carbon metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSSON300269:GJJF-1550-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductase FolM (EC:1.5.1.3)
Short name:
DHFR
Gene namesi
Name:folM
Ordered Locus Names:SSON_1554
OrganismiShigella sonnei (strain Ss046)
Taxonomic identifieri300269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000002529: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Dihydrofolate reductase FolMPRO_0000339403Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300269.SSON_1554.

Structurei

3D structure databases

ProteinModelPortaliQ3Z1V9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK13938.
OMAiMKIAPGE.
OrthoDBiEOG6WDSG3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3Z1V9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKAQPLPIL ITGGGRRIGL ALAWHFINQK QPVIVSYRTH YPAIDGLIKA
60 70 80 90 100
GAQCIQADFS TNDGVMAFAD EVLKSPHGLR AILHNASAWM AEKPGAPLAD
110 120 130 140 150
VLACMMQIHV NTPYLLNHAL ERLLRGHGHA ASDIIHFTDY VVERGSDKHI
160 170 180 190 200
AYAASKAALD NMTRSFARKL APEVKVNSIA PSLILFNEHD DAEYRQQALN
210 220 230 240
KSLMKTAPGE KEVIDLVDYL LTSCFVTGRS FPLDGGRHLR
Length:240
Mass (Da):26,328
Last modified:September 27, 2005 - v1
Checksum:i749E62F921924298
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000038 Genomic DNA. Translation: AAZ88253.1.
RefSeqiYP_310488.1. NC_007384.1.

Genome annotation databases

EnsemblBacteriaiAAZ88253; AAZ88253; SSON_1554.
GeneIDi3669502.
KEGGissn:SSON_1554.
PATRICi18737006. VBIShiSon107113_1851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000038 Genomic DNA. Translation: AAZ88253.1 .
RefSeqi YP_310488.1. NC_007384.1.

3D structure databases

ProteinModelPortali Q3Z1V9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300269.SSON_1554.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ88253 ; AAZ88253 ; SSON_1554 .
GeneIDi 3669502.
KEGGi ssn:SSON_1554.
PATRICi 18737006. VBIShiSon107113_1851.

Phylogenomic databases

eggNOGi COG1028.
KOi K13938.
OMAi MKIAPGE.
OrthoDBi EOG6WDSG3.

Enzyme and pathway databases

BioCyci SSON300269:GJJF-1550-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ss046.

Entry informationi

Entry nameiFOLM_SHISS
AccessioniPrimary (citable) accession number: Q3Z1V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 27, 2005
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3