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Q3Z1M2

- MAO1_SHISS

UniProt

Q3Z1M2 - MAO1_SHISS

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Protein

NAD-dependent malic enzyme

Gene

maeA

Organism
Shigella sonnei (strain Ss046)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = pyruvate + CO2 + NADH.UniRule annotation
Oxaloacetate = pyruvate + CO2.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton donorUniRule annotation
Binding sitei157 – 1571NADUniRule annotation
Active sitei175 – 1751Proton acceptorUniRule annotation
Metal bindingi246 – 2461Divalent metal cationUniRule annotation
Metal bindingi247 – 2471Divalent metal cationUniRule annotation
Metal bindingi270 – 2701Divalent metal cationUniRule annotation
Binding sitei270 – 2701NADUniRule annotation
Sitei270 – 2701Important for activityUniRule annotation
Binding sitei418 – 4181NADUniRule annotation

GO - Molecular functioni

  1. malate dehydrogenase (decarboxylating) (NAD+) activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. NAD binding Source: InterPro
  4. oxaloacetate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. malate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD

Enzyme and pathway databases

BioCyciSSON300269:GJJF-1641-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent malic enzymeUniRule annotation (EC:1.1.1.38UniRule annotation)
Short name:
NAD-MEUniRule annotation
Gene namesi
Name:maeAUniRule annotation
Ordered Locus Names:SSON_1645
OrganismiShigella sonnei (strain Ss046)
Taxonomic identifieri300269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000002529: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565NAD-dependent malic enzymePRO_0000323540Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi300269.SSON_1645.

Structurei

3D structure databases

ProteinModelPortaliQ3Z1M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malic enzymes family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0281.
HOGENOMiHOG000042487.
KOiK00027.
OrthoDBiEOG6QVRGM.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01619. NAD_malic_enz.
InterProiIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
IPR023667. NAD_malic_enz_proteobac.
[Graphical view]
PfamiPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM00919. Malic_M. 1 hit.
[Graphical view]
PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3Z1M2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPKTKKQRS LYIPYAGPVL LEFPLLNKGS AFSMEERRNF NLLGLLPEVV
60 70 80 90 100
ETIEEQAERA WIQYQGFKTE IDKHIYLRNI QDTNETLFYR LVNNHLDEMM
110 120 130 140 150
PVIYTPTVGA ACERFSEIYR RSRGVFISYQ NRHNMDDILQ NVPNHNIKVI
160 170 180 190 200
VVTDGERILG LGDQGIGGMG IPIGKLSLYT ACGGISPAYT LPVVLDVGTN
210 220 230 240 250
NQQLLNDPLY MGWRNPRITD DEYYEFVDEF IQAVKQRWPD VLLQFEDFAQ
260 270 280 290 300
KNAMPLLNRY RNEICSFNDD IQGTAAVTVG TLIAASRAAG GQLSEKKIVF
310 320 330 340 350
LGAGSAGCGI AEMIIAQTPR EGLSEEAARQ KVFMVDRFGL LTDKMPNLLP
360 370 380 390 400
FQTKLVQKRE NLSDWDTDSD VLSLLDVVRN VKPDILIGVS GQTGLFTEEI
410 420 430 440 450
IREMHKHCPR PIVMPLSNPT SRVEATPQDI IAWTEGNALV ATGSPFNPVV
460 470 480 490 500
WKDKIYPIAQ CNNAFIFPGI GLGVIASGAS RITDEMLMSA SETLAQYSPL
510 520 530 540 550
VLNGEGLVLP ELKDIQKVSR AIAFAVGKMA QQQGVAVKTS AEALQQAIDD
560
NFWQAEYRDY RRTSI
Length:565
Mass (Da):63,132
Last modified:March 18, 2008 - v2
Checksum:iEFD2C9A3F7028F4D
GO

Sequence cautioni

The sequence AAZ88340.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000038 Genomic DNA. Translation: AAZ88340.1. Different initiation.
RefSeqiYP_310575.2. NC_007384.1.

Genome annotation databases

EnsemblBacteriaiAAZ88340; AAZ88340; SSON_1645.
GeneIDi3668674.
KEGGissn:SSON_1645.
PATRICi18737246. VBIShiSon107113_1971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000038 Genomic DNA. Translation: AAZ88340.1 . Different initiation.
RefSeqi YP_310575.2. NC_007384.1.

3D structure databases

ProteinModelPortali Q3Z1M2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300269.SSON_1645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ88340 ; AAZ88340 ; SSON_1645 .
GeneIDi 3668674.
KEGGi ssn:SSON_1645.
PATRICi 18737246. VBIShiSon107113_1971.

Phylogenomic databases

eggNOGi COG0281.
HOGENOMi HOG000042487.
KOi K00027.
OrthoDBi EOG6QVRGM.

Enzyme and pathway databases

BioCyci SSON300269:GJJF-1641-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_01619. NAD_malic_enz.
InterProi IPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
IPR023667. NAD_malic_enz_proteobac.
[Graphical view ]
Pfami PF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF000106. ME. 1 hit.
PRINTSi PR00072. MALOXRDTASE.
SMARTi SM00919. Malic_M. 1 hit.
[Graphical view ]
PROSITEi PS00331. MALIC_ENZYMES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ss046.

Entry informationi

Entry nameiMAO1_SHISS
AccessioniPrimary (citable) accession number: Q3Z1M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 26, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3