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Q3Z1M2

- MAO1_SHISS

UniProt

Q3Z1M2 - MAO1_SHISS

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Protein
NAD-dependent malic enzyme
Gene
maeA, SSON_1645
Organism
Shigella sonnei (strain Ss046)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = pyruvate + CO2 + NADH.UniRule annotation
Oxaloacetate = pyruvate + CO2.UniRule annotation

Cofactori

Divalent metal cations. Prefers magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton donor By similarity
Binding sitei157 – 1571NAD By similarity
Active sitei175 – 1751Proton acceptor By similarity
Metal bindingi246 – 2461Divalent metal cation By similarity
Metal bindingi247 – 2471Divalent metal cation By similarity
Metal bindingi270 – 2701Divalent metal cation By similarity
Binding sitei270 – 2701NAD By similarity
Sitei270 – 2701Important for activity By similarity
Binding sitei418 – 4181NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. malate dehydrogenase (decarboxylating) (NAD+) activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
  4. oxaloacetate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. malate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD

Enzyme and pathway databases

BioCyciSSON300269:GJJF-1641-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent malic enzyme (EC:1.1.1.38)
Short name:
NAD-ME
Gene namesi
Name:maeA
Ordered Locus Names:SSON_1645
OrganismiShigella sonnei (strain Ss046)
Taxonomic identifieri300269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000002529: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565NAD-dependent malic enzymeUniRule annotation
PRO_0000323540Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi300269.SSON_1645.

Structurei

3D structure databases

ProteinModelPortaliQ3Z1M2.

Family & Domainsi

Sequence similaritiesi

Belongs to the malic enzymes family.

Phylogenomic databases

eggNOGiCOG0281.
HOGENOMiHOG000042487.
KOiK00027.
OrthoDBiEOG6QVRGM.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01619. NAD_malic_enz.
InterProiIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
IPR023667. NAD_malic_enz_proteobac.
[Graphical view]
PfamiPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM00919. Malic_M. 1 hit.
[Graphical view]
PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3Z1M2-1 [UniParc]FASTAAdd to Basket

« Hide

MEPKTKKQRS LYIPYAGPVL LEFPLLNKGS AFSMEERRNF NLLGLLPEVV    50
ETIEEQAERA WIQYQGFKTE IDKHIYLRNI QDTNETLFYR LVNNHLDEMM 100
PVIYTPTVGA ACERFSEIYR RSRGVFISYQ NRHNMDDILQ NVPNHNIKVI 150
VVTDGERILG LGDQGIGGMG IPIGKLSLYT ACGGISPAYT LPVVLDVGTN 200
NQQLLNDPLY MGWRNPRITD DEYYEFVDEF IQAVKQRWPD VLLQFEDFAQ 250
KNAMPLLNRY RNEICSFNDD IQGTAAVTVG TLIAASRAAG GQLSEKKIVF 300
LGAGSAGCGI AEMIIAQTPR EGLSEEAARQ KVFMVDRFGL LTDKMPNLLP 350
FQTKLVQKRE NLSDWDTDSD VLSLLDVVRN VKPDILIGVS GQTGLFTEEI 400
IREMHKHCPR PIVMPLSNPT SRVEATPQDI IAWTEGNALV ATGSPFNPVV 450
WKDKIYPIAQ CNNAFIFPGI GLGVIASGAS RITDEMLMSA SETLAQYSPL 500
VLNGEGLVLP ELKDIQKVSR AIAFAVGKMA QQQGVAVKTS AEALQQAIDD 550
NFWQAEYRDY RRTSI 565
Length:565
Mass (Da):63,132
Last modified:March 18, 2008 - v2
Checksum:iEFD2C9A3F7028F4D
GO

Sequence cautioni

The sequence AAZ88340.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000038 Genomic DNA. Translation: AAZ88340.1. Different initiation.
RefSeqiYP_310575.2. NC_007384.1.

Genome annotation databases

EnsemblBacteriaiAAZ88340; AAZ88340; SSON_1645.
GeneIDi3668674.
KEGGissn:SSON_1645.
PATRICi18737246. VBIShiSon107113_1971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000038 Genomic DNA. Translation: AAZ88340.1 . Different initiation.
RefSeqi YP_310575.2. NC_007384.1.

3D structure databases

ProteinModelPortali Q3Z1M2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300269.SSON_1645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ88340 ; AAZ88340 ; SSON_1645 .
GeneIDi 3668674.
KEGGi ssn:SSON_1645.
PATRICi 18737246. VBIShiSon107113_1971.

Phylogenomic databases

eggNOGi COG0281.
HOGENOMi HOG000042487.
KOi K00027.
OrthoDBi EOG6QVRGM.

Enzyme and pathway databases

BioCyci SSON300269:GJJF-1641-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_01619. NAD_malic_enz.
InterProi IPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
IPR023667. NAD_malic_enz_proteobac.
[Graphical view ]
Pfami PF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF000106. ME. 1 hit.
PRINTSi PR00072. MALOXRDTASE.
SMARTi SM00919. Malic_M. 1 hit.
[Graphical view ]
PROSITEi PS00331. MALIC_ENZYMES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ss046.

Entry informationi

Entry nameiMAO1_SHISS
AccessioniPrimary (citable) accession number: Q3Z1M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3