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Protein

NAD-dependent malic enzyme

Gene

maeA

Organism
Shigella sonnei (strain Ss046)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = pyruvate + CO2 + NADH.UniRule annotation
Oxaloacetate = pyruvate + CO2.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104Proton donorUniRule annotation1
Binding sitei157NADUniRule annotation1
Active sitei175Proton acceptorUniRule annotation1
Metal bindingi246Divalent metal cationUniRule annotation1
Metal bindingi247Divalent metal cationUniRule annotation1
Metal bindingi270Divalent metal cationUniRule annotation1
Binding sitei270NADUniRule annotation1
Sitei270Important for activityUniRule annotation1
Binding sitei418NADUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD

Enzyme and pathway databases

BioCyciSSON300269:G1GL2-1987-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent malic enzymeUniRule annotation (EC:1.1.1.38UniRule annotation)
Short name:
NAD-MEUniRule annotation
Gene namesi
Name:maeAUniRule annotation
Ordered Locus Names:SSON_1645
OrganismiShigella sonnei (strain Ss046)
Taxonomic identifieri300269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002529 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003235401 – 565NAD-dependent malic enzymeAdd BLAST565

Proteomic databases

PRIDEiQ3Z1M2

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ3Z1M2
SMRiQ3Z1M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malic enzymes family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000042487
KOiK00027

Family and domain databases

Gene3Di3.40.50.10380, 1 hit
HAMAPiMF_01619 NAD_malic_enz, 1 hit
InterProiView protein in InterPro
IPR015884 Malic_enzyme_CS
IPR012301 Malic_N_dom
IPR037062 Malic_N_dom_sf
IPR012302 Malic_NAD-bd
IPR001891 Malic_OxRdtase
IPR036291 NAD(P)-bd_dom_sf
IPR023667 NAD_malic_enz_proteobac
PfamiView protein in Pfam
PF00390 malic, 1 hit
PF03949 Malic_M, 1 hit
PIRSFiPIRSF000106 ME, 1 hit
PRINTSiPR00072 MALOXRDTASE
SMARTiView protein in SMART
SM01274 malic, 1 hit
SM00919 Malic_M, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00331 MALIC_ENZYMES, 1 hit

Sequencei

Sequence statusi: Complete.

Q3Z1M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPKTKKQRS LYIPYAGPVL LEFPLLNKGS AFSMEERRNF NLLGLLPEVV
60 70 80 90 100
ETIEEQAERA WIQYQGFKTE IDKHIYLRNI QDTNETLFYR LVNNHLDEMM
110 120 130 140 150
PVIYTPTVGA ACERFSEIYR RSRGVFISYQ NRHNMDDILQ NVPNHNIKVI
160 170 180 190 200
VVTDGERILG LGDQGIGGMG IPIGKLSLYT ACGGISPAYT LPVVLDVGTN
210 220 230 240 250
NQQLLNDPLY MGWRNPRITD DEYYEFVDEF IQAVKQRWPD VLLQFEDFAQ
260 270 280 290 300
KNAMPLLNRY RNEICSFNDD IQGTAAVTVG TLIAASRAAG GQLSEKKIVF
310 320 330 340 350
LGAGSAGCGI AEMIIAQTPR EGLSEEAARQ KVFMVDRFGL LTDKMPNLLP
360 370 380 390 400
FQTKLVQKRE NLSDWDTDSD VLSLLDVVRN VKPDILIGVS GQTGLFTEEI
410 420 430 440 450
IREMHKHCPR PIVMPLSNPT SRVEATPQDI IAWTEGNALV ATGSPFNPVV
460 470 480 490 500
WKDKIYPIAQ CNNAFIFPGI GLGVIASGAS RITDEMLMSA SETLAQYSPL
510 520 530 540 550
VLNGEGLVLP ELKDIQKVSR AIAFAVGKMA QQQGVAVKTS AEALQQAIDD
560
NFWQAEYRDY RRTSI
Length:565
Mass (Da):63,132
Last modified:March 18, 2008 - v2
Checksum:iEFD2C9A3F7028F4D
GO

Sequence cautioni

The sequence AAZ88340 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000038 Genomic DNA Translation: AAZ88340.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiAAZ88340; AAZ88340; SSON_1645
KEGGissn:SSON_1645

Similar proteinsi

Entry informationi

Entry nameiMAO1_SHISS
AccessioniPrimary (citable) accession number: Q3Z1M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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