ID   CDD_SHISS               Reviewed;         294 AA.
AC   Q3Z062;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
DE            Short=CDA;
GN   Name=cdd; OrderedLocusNames=SSON_2199;
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X.,
RA   Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S.,
RA   Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y.,
RA   Qiang B., Hou Y., Yu J., Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic
RT   agents of bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine
CC       and 2'-deoxycytidine for UMP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; CP000038; AAZ88850.1; -; Genomic_DNA.
DR   RefSeq; YP_311085.1; -.
DR   SMR; Q3Z062; 1-294.
DR   GeneID; 3667635; -.
DR   GenomeReviews; CP000038_GR; SSON_2199.
DR   KEGG; ssn:SSON_2199; -.
DR   HOGENOM; Q3Z062; -.
DR   OMA; Q3Z062; FSPCGHC.
DR   BioCyc; SSON300269:SSO_2199-MON; -.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046087; P:cytidine metabolic process; IEA:InterPro.
DR   HAMAP; MF_01558; -; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR006263; Cyt_deam_dimer.
DR   InterPro; IPR013171; dC_C_deam_Zn_bd.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   Pfam; PF08211; dCMP_cyt_deam_2; 1.
DR   TIGRFAMs; TIGR01355; cyt_deam_dimer; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    294       Cytidine deaminase.
FT                                /FTId=PRO_0000171668.
FT   REGION       89     91       Substrate binding (By similarity).
FT   ACT_SITE    104    104       Proton donor (By similarity).
FT   METAL       102    102       Zinc; catalytic (By similarity).
FT   METAL       129    129       Zinc; catalytic (By similarity).
FT   METAL       132    132       Zinc; catalytic (By similarity).
SQ   SEQUENCE   294 AA;  31540 MW;  F0B5CD68AB145D7D CRC64;
     MHPRFQTAFA QLADNLQSAL EPILADKYFP ALLTGEQVSS LKSATGLDED ALAFALLPLA
     AACARTPLSN FNVGAIARGV SGTWYFGANM EFIGATMQQT VHAEQSAISH AWLSGEKALA
     AITVNYTPCG HCRQFMNELN SGLDLRIHLP GREAHALRDY LPDAFGPKDL EIKTLLMDEQ
     DHGYALTGDA LSQAAIAAAN RSHMPYSKSP SGVALECKDG RIFSGSYAEN AAFNPTLPPL
     QGALILLNLK GYDYPDIQRA VLAEKADAPL IQWDATSATL KALGCHSIDR VLLA
//