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Q3YZV0

- ARND_SHISS

UniProt

Q3YZV0 - ARND_SHISS

Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Shigella sonnei (strain Ss046)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

    Catalytic activityi

    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP
    3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    4. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciSSON300269:GJJF-2313-MONOMER.
    UniPathwayiUPA00030.
    UPA00036; UER00496.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
    Gene namesi
    Name:arnDUniRule annotation
    Ordered Locus Names:SSON_2317
    OrganismiShigella sonnei (strain Ss046)
    Taxonomic identifieri300269 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000002529: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDPRO_0000383547Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi300269.SSON_2317.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3YZV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 260259NodB homologyUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation
    Contains 1 NodB homology domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0726.
    HOGENOMiHOG000261199.
    KOiK13014.
    OMAiLHAWDHF.
    OrthoDBiEOG6423D0.

    Family and domain databases

    Gene3Di3.20.20.370. 2 hits.
    HAMAPiMF_01870. ArnD.
    InterProiIPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view]
    PfamiPF01522. Polysacc_deac_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF88713. SSF88713. 2 hits.
    PROSITEiPS51677. NODB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3YZV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKVGLRIDV DTFRGTREGV PRLLEILSKH NIQASIFFSV GPDNMGRHLW    50
    RLVKPQFLWK MLRSNAASLY GWDILLAGTA WPGKEIGHAN ADIIREAAKH 100
    HEVGLHAWDH HAWQARSGNW DRQTMIDDIA RGLRTLEEII GQPVTCSAAA 150
    GWRADQKVIE AKEAFHLRYN SDCRGAMPFR PLLESGNPGT AQIPVTLPTW 200
    DEVIGRDVKA EDFNGWLLNR ILRDKGTPVY TIHAEVEGCA YQHNFVDLLK 250
    RAAQEGVTFC PLSELLSETL PLGQVVRGNI AGREGWLGCQ QIAGSR 296
    Length:296
    Mass (Da):33,112
    Last modified:September 27, 2005 - v1
    Checksum:iDDD0BEE55581DE3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000038 Genomic DNA. Translation: AAZ88962.1.
    RefSeqiYP_311197.1. NC_007384.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ88962; AAZ88962; SSON_2317.
    GeneIDi3668376.
    KEGGissn:SSON_2317.
    PATRICi18738908. VBIShiSon107113_2786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000038 Genomic DNA. Translation: AAZ88962.1 .
    RefSeqi YP_311197.1. NC_007384.1.

    3D structure databases

    ProteinModelPortali Q3YZV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300269.SSON_2317.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ88962 ; AAZ88962 ; SSON_2317 .
    GeneIDi 3668376.
    KEGGi ssn:SSON_2317.
    PATRICi 18738908. VBIShiSon107113_2786.

    Phylogenomic databases

    eggNOGi COG0726.
    HOGENOMi HOG000261199.
    KOi K13014.
    OMAi LHAWDHF.
    OrthoDBi EOG6423D0.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00036 ; UER00496 .
    BioCyci SSON300269:GJJF-2313-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.370. 2 hits.
    HAMAPi MF_01870. ArnD.
    InterProi IPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view ]
    Pfami PF01522. Polysacc_deac_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88713. SSF88713. 2 hits.
    PROSITEi PS51677. NODB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ss046.

    Entry informationi

    Entry nameiARND_SHISS
    AccessioniPrimary (citable) accession number: Q3YZV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3