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Q3YZH8

- RUSA_SHISS

UniProt

Q3YZH8 - RUSA_SHISS

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Protein
Crossover junction endodeoxyribonuclease RusA
Gene
rusA, SSON_2443
Organism
Shigella sonnei (strain Ss046)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC By similarity.

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi70 – 701Magnesium By similarity
Metal bindingi72 – 721Magnesium By similarity
Metal bindingi91 – 911Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSSON300269:GJJF-2439-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RusA (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RusA
Holliday junction resolvase
Gene namesi
Name:rusA
Ordered Locus Names:SSON_2443
OrganismiShigella sonnei (strain Ss046)
Taxonomic identifieri300269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000002529: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120Crossover junction endodeoxyribonuclease RusA
PRO_0000324838Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi300269.SSON_2443.

Structurei

3D structure databases

ProteinModelPortaliQ3YZH8.
SMRiQ3YZH8. Positions 1-120.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 164DNA binding By similarity
Regioni66 – 738DNA binding By similarity

Sequence similaritiesi

Belongs to the RusA family.

Phylogenomic databases

eggNOGiCOG4570.
HOGENOMiHOG000119986.
KOiK01160.
OMAiRGIHYIS.
OrthoDBiEOG66HVH9.

Family and domain databases

Gene3Di3.30.1330.70. 1 hit.
InterProiIPR016281. Endonuclease_RusA.
IPR008822. Endonuclease_RusA-like.
[Graphical view]
PfamiPF05866. RusA. 1 hit.
[Graphical view]
PIRSFiPIRSF001007. RusA. 1 hit.
SUPFAMiSSF103084. SSF103084. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3YZH8-1 [UniParc]FASTAAdd to Basket

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MNTYSITLPW PPSNNRYYRH NRGRTHISAE GQAYRDNVTR IIKNAMLDIG    50
LAMPVKIRIE CHMPDRRRRD LDNLQKAAFD ALTKAGFWLD DAQVVDYRVV 100
KMPVTKGGRL ELTITEMGNE 120
Length:120
Mass (Da):13,890
Last modified:September 27, 2005 - v1
Checksum:iA0608F73D385C008
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000038 Genomic DNA. Translation: AAZ89084.1.
RefSeqiYP_311319.1. NC_007384.1.

Genome annotation databases

EnsemblBacteriaiAAZ89084; AAZ89084; SSON_2443.
GeneIDi3668593.
KEGGissn:SSON_2443.
PATRICi18739222. VBIShiSon107113_2942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000038 Genomic DNA. Translation: AAZ89084.1 .
RefSeqi YP_311319.1. NC_007384.1.

3D structure databases

ProteinModelPortali Q3YZH8.
SMRi Q3YZH8. Positions 1-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300269.SSON_2443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ89084 ; AAZ89084 ; SSON_2443 .
GeneIDi 3668593.
KEGGi ssn:SSON_2443.
PATRICi 18739222. VBIShiSon107113_2942.

Phylogenomic databases

eggNOGi COG4570.
HOGENOMi HOG000119986.
KOi K01160.
OMAi RGIHYIS.
OrthoDBi EOG66HVH9.

Enzyme and pathway databases

BioCyci SSON300269:GJJF-2439-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.70. 1 hit.
InterProi IPR016281. Endonuclease_RusA.
IPR008822. Endonuclease_RusA-like.
[Graphical view ]
Pfami PF05866. RusA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001007. RusA. 1 hit.
SUPFAMi SSF103084. SSF103084. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ss046.

Entry informationi

Entry nameiRUSA_SHISS
AccessioniPrimary (citable) accession number: Q3YZH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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