Reviewed, UniProtKB/Swiss-Prot Q3YZC3 (PDXK_SHISS)

Names and origin

Protein names

Recommended name:
    Pyridoxine kinase
    EC=2.7.1.35
Alternative name(s):
    Pyridoxal kinase
    Vitamin B6 kinase
    Pyridoxamine kinase
    PN/PL/PM kinase

Gene names

Name:	pdxK
Ordered Locus Names:	SSON_2508

Organism

Shigella sonnei (strain Ss046) [Complete proteome] [HAMAP]

Taxonomic identifier

300269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates By similarity.
Catalytic activity	ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01638
Cofactor	Zinc or magnesium By similarity.
Sequence similarities	Belongs to the pyridoxine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP pyridoxine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP pyridoxal kinase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Pyridoxine kinase HAMAP MF_01638		PRO_0000268844
Regions
	Nucleotide binding	195 – 196	2	ATP By similarity
	Nucleotide binding	220 – 232	13	ATP By similarity
Sites
	Binding site	23	1	Substrate By similarity
	Binding site	136	1	Substrate By similarity
	Binding site	233	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3YZC3-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 902F8C55E5B7804B	FASTA	283	30,860
	10 20 30 40 50 60 MSSLLLFNDK SRALQADIVA VQSQVVYGSV GNSIAVPAIK QNGLNVFAVP TVLLSNTPHY 70 80 90 100 110 120 DTFYGGAIPD EWFSGYLRAL QERDALRQLR AVTTGYMGTA SQIKILAEWL TALRKDHPDL 130 140 150 160 170 180 LIMVDPVIGD IDSGIYVKPD LPEAYRQYLL PLAQGITPNI FELEILTGKN CRDLDSAIAA 190 200 210 220 230 240 AKSLLSDTLK WVVITSASGN EENQEMQVVV VSADSVNVIS HSRVKTDLKG TGDLFCAQLI 250 260 270 280 SGLLKGKALN DAVHRAGLRV LEVMRYTQQH ESDELILPPL AEA

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000038 Genomic DNA. Translation: AAZ89139.1.
RefSeq	YP_311374.1.
3D structure databases
SMR	Q3YZC3. Positions 2-280.
ModBase	Search...
Genome annotation databases
GeneID	3667660.
GenomeReviews	Gene locus SSON_2508 in contig CP000038_GR.
KEGG	ssn:SSON_2508.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3YZC3.
OMA	Q3YZC3. ACICNEL.
Enzyme and pathway databases
BioCyc	SSON300269:SSO_2508-MON.
Family and domain databases
HAMAP	MF_01638. [Tree]
InterPro	IPR013749. HMP-P_kinase-1. IPR004625. PyrdxlP_synth_PyrdxlKinase. [Graphical view]
Pfam	PF08543. Phos_pyr_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00687. pyridox_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDXK_SHISS

Accession

Primary (citable) accession number: Q3YZC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)