Reviewed, UniProtKB/Swiss-Prot Q3YXI9 (GLNE_SHISS)

Names and origin

Protein names

Recommended name:
    Glutamate-ammonia-ligase adenylyltransferase
    EC=2.7.7.42
Alternative name(s):
    [Glutamate--ammonia-ligase] adenylyltransferase
    Glutamine-synthetase adenylyltransferase
      Short name=ATase

Gene names

Name:	glnE
Ordered Locus Names:	SSON_3190

Organism

Shigella sonnei (strain Ss046) [Complete proteome] [HAMAP]

Taxonomic identifier

300269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	946 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Adenylation and deadenylation of glutamine synthetase By similarity.
Catalytic activity	ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. HAMAP MF_00802
Sequence similarities	Belongs to the glnE family.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW [glutamate-ammonia-ligase] adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 946	946	Glutamate-ammonia-ligase adenylyltransferase HAMAP MF_00802		PRO_1000047017
Regions
	Region	91 – 302	212	GlnE 1 HAMAP MF_00802
	Region	609 – 830	222	GlnE 2 HAMAP MF_00802

Sequences

	Sequence		Length	Mass (Da)
	Q3YXI9-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: FF6C8C9B0BEB1947	FASTA	946	108,317
	10 20 30 40 50 60 MKPLSSPLQQ YRQTVVERLP EPLAEEPLSA QAKSVLTFSD FVQDSIIAHR EWLTELESQP 70 80 90 100 110 120 PQADEWQHYA AWLQEALSNV SDEAGLMREL RLFRRRIMVR IAWAQTLALV TEESILQQLS 130 140 150 160 170 180 YLAETLIVAA RDWLYDACCR EWGTPCNAQG EAQPLLILGM GKLGGGELNF SSDIDLIFAW 190 200 210 220 230 240 PEHGCTQGGR RELDNAQFFT RMGQRLIKVL DQPTQDGFVY RVDMRLRPFG ESGPLVLSFA 250 260 270 280 290 300 ALEDYYQEQG RDWERYAMVK ARIMGDSEGV YANELRAMLR PFVFRRYIDF SVIQSLRNMK 310 320 330 340 350 360 GMIAREVRRR GLTDNIKLGA GGIREIEFIV QVFQLIRGGR EPSLQSCSLL PTLSAIAALH 370 380 390 400 410 420 LLSENDAEQL RVAYLFLRRL ENLLQSINDE QTQTLPSDEL NRARLAWAMD FADWPQLTGA 430 440 450 460 470 480 LTAHMNNVRR VFNELIGDDE SETQEESLSE QWRELWQDAL QEDDTTPVLA HLSEDDRKQV 490 500 510 520 530 540 LTLISDFRKE LDKRTIGPRG RQVLDHLMPH LLSDVCARED AAVTLSRITA LLVGIVTRTT 550 560 570 580 590 600 YLELLSEFPA ALNHLISLCA ASPMIASQLA RYPLLLDELL DPNTLYQPTA TDAYRDELRQ 610 620 630 640 650 660 YLLRVPEDDE EQQLEALRQF KQAQLLRIAA ADIAGTLPVM KVSDHLTWLA EAMIDAVVQQ 670 680 690 700 710 720 AWVQMVARYG KPNHLNDREG RGFAVVGYGK LGGWELGYSS DLDLIFLHDC PMDAMTDGER 730 740 750 760 770 780 EIDGRQFYLR LAQRIMHLFS TRTSSGILYE VDARLRPSGA AGMLVTSTEA FADYQKNEAW 790 800 810 820 830 840 TWEHQALVRA RVVYGDPQLT AHFDAVRREI MTLPREGRTL QTEVREMREK MRAHLGNKHR 850 860 870 880 890 900 DRFDIKADEG GITDIEFITQ YLVLRYAHEK PKLTRWSDNV RILELLAQND IMEEQEAMAL 910 920 930 940 TRAYTTLRDE LHHLALQELP GHVSGDCFTA ERDLVRASWQ KWLVEE

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000038 Genomic DNA. Translation: AAZ89773.1.
RefSeq	YP_312008.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3669346.
GenomeReviews	Gene locus SSON_3190 in contig CP000038_GR.
KEGG	ssn:SSON_3190.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3YXI9.
OMA	Q3YXI9. WERYAMI.
Enzyme and pathway databases
BioCyc	SSON300269:SSO_3190-MON.
Family and domain databases
HAMAP	MF_00802. [Tree]
InterPro	IPR005190. GlnE. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view]
Pfam	PF08335. GlnD_UR_UTase. 1 hit. PF03710. GlnE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLNE_SHISS

Accession

Primary (citable) accession number: Q3YXI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)