Reviewed, UniProtKB/Swiss-Prot Q3YXI2 (TTDA_SHISS)

Names and origin

Protein names

Recommended name:
    L(+)-tartrate dehydratase subunit alpha
      Short name=L-TTD alpha
    EC=4.2.1.32

Gene names

Name:	ttdA
Ordered Locus Names:	SSON_3198

Organism

Shigella sonnei (strain Ss046) [Complete proteome] [HAMAP]

Taxonomic identifier

300269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R,R)-tartrate = oxaloacetate + H2O.
Cofactor	Iron-sulfur By similarity.
Subunit structure	Tetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the class-I fumarase family.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L(+)-tartrate dehydratase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	L(+)-tartrate dehydratase subunit alpha		PRO_0000262702
Sites
	Metal binding	71	1	Iron-sulfur By similarity
	Metal binding	190	1	Iron-sulfur By similarity
	Metal binding	277	1	Iron-sulfur By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3YXI2-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: CBE29FEB6C47DB81	FASTA	303	32,734
	10 20 30 40 50 60 MMSESNKQQA VNKLTEIVAN FTAMISTRMP DDVVDKLKQL KDAETSSMGK IIYHTMFDNM 70 80 90 100 110 120 QKAIDLNRPA CQDTGEIMFF VKVGSRFPLL GELQSILKQA VEEATVKAPL RHNAVEIFDE 130 140 150 160 170 180 VNTGKNTGSG VPWVTWDIIP DNDDAEIEVY MAGGGCTLPG RSKVLMPSEG YEGVVKFVFE 190 200 210 220 230 240 NISTLAVNAC PPVLVGVGIA TSVETAAVLS RKAILRPIGS RHPNPKAAEL ELRLEEGLNR 250 260 270 280 290 300 LGIGPQGLTG NSSVMGVHIE SAARHPSTIG VAVSTGCWAH RRGTLLVHAD LTFENLSHTR SAL

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000038 Genomic DNA. Translation: AAZ89780.1.
RefSeq	YP_312015.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3669354.
GenomeReviews	Gene locus SSON_3198 in contig CP000038_GR.
KEGG	ssn:SSON_3198.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3YXI2.
OMA	Q3YXI2. VNACPPL.
Enzyme and pathway databases
BioCyc	SSON300269:SSO_3198-MON.
Family and domain databases
InterPro	IPR004646. TtdA_fumA_fumB. [Graphical view]
Pfam	PF05681. Fumerase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00722. ttdA_fumA_fumB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TTDA_SHISS

Accession

Primary (citable) accession number: Q3YXI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)