Reviewed, UniProtKB/Swiss-Prot Q3YWN8 (GPH_SHISS)

Names and origin

Protein names

Recommended name:
    Phosphoglycolate phosphatase
      Short name=PGPase
      Short name=PGP
    EC=3.1.3.18

Gene names

Ordered Locus Names:

SSON_3516

Organism

Shigella sonnei (strain Ss046) [Complete proteome] [HAMAP]

Taxonomic identifier

300269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress By similarity.
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_00495
Cofactor	Chloride By similarity. Magnesium By similarity.
Pathway	Organic acid metabolism; glycolic acid biosynthesis; glycolic acid from 2-phosphoglycolic acid: step 1/1. HAMAP MF_00495
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. CbbY/cbbZ/gph/yieH family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	Chloride Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chloride ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Phosphoglycolate phosphatase HAMAP MF_00495		PRO_0000238180
Sites
	Active site	13	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3YWN8-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 4DCCDA65B37A0E72	FASTA	252	27,403
	10 20 30 40 50 60 MNKFEDIRGV AFDLDGTLVD SAPGLAAAVD MALYALELPI AGEERVITWI GNGADVLMER 70 80 90 100 110 120 ALTWARQERA TQRKTMGKPP VDDDIPAEEQ VRILRKLFDR YYGEVAEEGT FLFPHVADTL 130 140 150 160 170 180 GALQAKGLPL GLVTNKPTPF VAPLLEALDI AKYFSVVIGG DDVQNKKPHP DPLLLVAERM 190 200 210 220 230 240 GIAPQQMLFV GDSRNDIQAA KAAGCPSVGL TYGYNYGEAI DLSQPDVIYQ SINDLLPALG 250 LPHSENQESK ND

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000038 Genomic DNA. Translation: AAZ90074.1.
RefSeq	YP_312309.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3667362.
GenomeReviews	Gene locus SSON_3516 in contig CP000038_GR.
KEGG	ssn:SSON_3516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3YWN8.
OMA	Q3YWN8. AVCEQFS.
Enzyme and pathway databases
BioCyc	SSON300269:SSO_3516-MON.
Family and domain databases
HAMAP	MF_00495. [Tree]
InterPro	IPR005834. Dehalogen-like_hydro. IPR006439. HAD-SF_hydro_IA_v1. IPR006402. HAD-SF_hydro_IA_v3. IPR005833. Haloacid_DH/epoxide_hydro. IPR006346. PGP_bact. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00413. HADHALOGNASE.
TIGRFAMs	TIGR01549. HAD-SF-IA-v1. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit. TIGR01449. PGP_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPH_SHISS

Accession

Primary (citable) accession number: Q3YWN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)