ID   GPPA_SHISS              Reviewed;         494 AA.
AC   Q3YVI5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase;
DE            EC=3.6.1.40;
DE   AltName: Full=Guanosine pentaphosphate phosphohydrolase;
DE   AltName: Full=pppGpp-5'-phosphohydrolase;
GN   Name=gppA; OrderedLocusNames=SSON_3950;
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X.,
RA   Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S.,
RA   Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y.,
RA   Qiang B., Hou Y., Yu J., Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic
RT   agents of bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate
CC       (pppGpp) is a cytoplasmic signaling molecule which together with
CC       ppGpp controls the "stringent response", an adaptive process that
CC       allows bacteria to respond to amino acid starvation, resulting in
CC       the coordinated regulation of numerous cellular activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Guanosine 5'-triphosphate,3'-diphosphate +
CC       H(2)O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.
CC   -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP:
CC       step 1/2.
CC   -!- SIMILARITY: Belongs to the gppA/ppx family. GppA subfamily.
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DR   EMBL; CP000038; AAZ90477.1; -; Genomic_DNA.
DR   RefSeq; YP_312712.1; -.
DR   GeneID; 3669760; -.
DR   GenomeReviews; CP000038_GR; SSON_3950.
DR   KEGG; ssn:SSON_3950; -.
DR   HOGENOM; Q3YVI5; -.
DR   OMA; Q3YVI5; QYTDLGW.
DR   BioCyc; SSON300269:SSO_3950-MON; -.
DR   GO; GO:0008894; F:guanosine-5'-triphosphate,3'-diphosphate di...; IEA:HAMAP.
DR   HAMAP; MF_01550; -; 1.
DR   InterPro; IPR003695; Ppx_GppA.
DR   Pfam; PF02541; Ppx-GppA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    494       Guanosine-5'-triphosphate,3'-diphosphate
FT                                pyrophosphatase.
FT                                /FTId=PRO_0000194291.
SQ   SEQUENCE   494 AA;  54871 MW;  423F8AB554A0621E CRC64;
     MGSTSSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSEN ALSNEAMERG
     WQCLRLFAER LQDIPPSQIR VVATATLRLA VNAGDFIANA QEILGCPVQV ISGEEEARLI
     YQGVAHTTGG ADQRLVVDIG GASTELVTGT GAQTTSLFSL SMGCVTWLER YFADRNLGQE
     NFDAAEKAAR EVLRPVADEL RYHGWKVCVG ASGTVQALQE IMMAQGMDER ITLEKLQQLK
     QRAIHCGRLE ELEIDGLTLE RALVFPSGLA ILIAIFTELN IQCMTLAGGA LREGLVYGML
     HLAVEQDIRS RTLRNIQRRF MIDIDQAQRV AKVAANFFDQ VEKEWHLEAI SRDLLISACQ
     LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL LLNQTNPVDL SSLHQQNAVP
     PRVAEQLCRL LRLAIIFASR RRDDLVPEMT LQANHELLTL TLPQGWLTQH PLGKEIIAQE
     SQWQSYVHWP LEVH
//