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Q3YVI5

- GPPA_SHISS

UniProt

Q3YVI5 - GPPA_SHISS

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, SSON_3950
Organism
Shigella sonnei (strain Ss046)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSSON300269:GJJF-3945-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:SSON_3950
OrganismiShigella sonnei (strain Ss046)
Taxonomic identifieri300269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000002529: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_0000194291Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300269.SSON_3950.

Structurei

3D structure databases

ProteinModelPortaliQ3YVI5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3YVI5-1 [UniParc]FASTAAdd to Basket

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MGSTSSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSEN    50
ALSNEAMERG WQCLRLFAER LQDIPPSQIR VVATATLRLA VNAGDFIANA 100
QEILGCPVQV ISGEEEARLI YQGVAHTTGG ADQRLVVDIG GASTELVTGT 150
GAQTTSLFSL SMGCVTWLER YFADRNLGQE NFDAAEKAAR EVLRPVADEL 200
RYHGWKVCVG ASGTVQALQE IMMAQGMDER ITLEKLQQLK QRAIHCGRLE 250
ELEIDGLTLE RALVFPSGLA ILIAIFTELN IQCMTLAGGA LREGLVYGML 300
HLAVEQDIRS RTLRNIQRRF MIDIDQAQRV AKVAANFFDQ VEKEWHLEAI 350
SRDLLISACQ LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL 400
LLNQTNPVDL SSLHQQNAVP PRVAEQLCRL LRLAIIFASR RRDDLVPEMT 450
LQANHELLTL TLPQGWLTQH PLGKEIIAQE SQWQSYVHWP LEVH 494
Length:494
Mass (Da):54,871
Last modified:September 27, 2005 - v1
Checksum:i423F8AB554A0621E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000038 Genomic DNA. Translation: AAZ90477.1.
RefSeqiYP_312712.1. NC_007384.1.

Genome annotation databases

EnsemblBacteriaiAAZ90477; AAZ90477; SSON_3950.
GeneIDi3669760.
KEGGissn:SSON_3950.
PATRICi18742822. VBIShiSon107113_4694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000038 Genomic DNA. Translation: AAZ90477.1 .
RefSeqi YP_312712.1. NC_007384.1.

3D structure databases

ProteinModelPortali Q3YVI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300269.SSON_3950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ90477 ; AAZ90477 ; SSON_3950 .
GeneIDi 3669760.
KEGGi ssn:SSON_3950.
PATRICi 18742822. VBIShiSon107113_4694.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci SSON300269:GJJF-3945-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ss046.

Entry informationi

Entry nameiGPPA_SHISS
AccessioniPrimary (citable) accession number: Q3YVI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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