Reviewed, UniProtKB/Swiss-Prot Q3YV74 (RHAD_SHISS)

Names and origin

Protein names

Recommended name:
    Rhamnulose-1-phosphate aldolase
    EC=4.1.2.19

Gene names

Name:	rhaD
Ordered Locus Names:	SSON_4072

Organism

Shigella sonnei (strain Ss046) [Complete proteome] [HAMAP]

Taxonomic identifier

300269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde By similarity.
Catalytic activity	L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. HAMAP MF_00770
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 3/3. HAMAP MF_00770
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldolase class II family. RhaD subfamily.

Ontologies

Keywords
Biological process	Rhamnose metabolism
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rhamnose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	rhamnulose-1-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Rhamnulose-1-phosphate aldolase HAMAP MF_00770		PRO_1000017345
Sites
	Active site	117	1	By similarity
	Metal binding	141	1	Zinc By similarity
	Metal binding	143	1	Zinc By similarity
	Metal binding	212	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3YV74-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: F41C09D12BD3C24C	FASTA	274	30,006
	10 20 30 40 50 60 MQNITQSWFV QGMIKATTDA WLKGWDERNG GNLTLRLDDA DIAPYHGNFH AQPRYIPLSQ 70 80 90 100 110 120 PMPLLANTPF IVTGSGKFFR NVQLDPAANL GVVKVDSDGA GYHILWGLTN EAVPTSELPA 130 140 150 160 170 180 HFLSHCERIK ATNGKDRVIM HCHATNLIAL TYVLENDTAV FTRQLWEGST ECLVVFPDGV 190 200 210 220 230 240 GILPWMVPGT DEIGQATAQE MQKHSLVLWP FHGVFGSGST LDETFGLIDT AEKSAQVLVK 250 260 270 VYSMGGMKQT ISREELIALG KRFGVTPLAS ALAL

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000038 Genomic DNA. Translation: AAZ90588.1.
RefSeq	YP_312823.1.
3D structure databases
SMR	Q3YV74. Positions 1-274.
ModBase	Search...
Genome annotation databases
GeneID	3669534.
GenomeReviews	Gene locus SSON_4072 in contig CP000038_GR.
KEGG	ssn:SSON_4072.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3YV74.
OMA	Q3YV74. MSHIARL.
Enzyme and pathway databases
BioCyc	SSON300269:SSO_4072-MON.
Family and domain databases
HAMAP	MF_00770. [Tree]
InterPro	IPR001303. Aldolase_II/adducin_N. IPR013447. RhaD. [Graphical view]
Gene3D	G3DSA:3.40.225.10. Aldolase_II/adducin_N. 1 hit.
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
TIGRFAMs	TIGR02624. rhamnu_1P_ald. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RHAD_SHISS

Accession

Primary (citable) accession number: Q3YV74

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)